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学科主题临床医学
Therapeutic Potentials of Mesenchymal Stem Cells Derived from Human Umbilical Cord
Fan, Cun-Gang; Zhang, Qing-jun; Zhou, Jing-ru
关键词Umbilical Cord Mesenchymal Stem Cell Wharton&Prime s Jelly Stromal Cell Differential Potential Neurological Diseases
刊名STEM CELL REVIEWS AND REPORTS
2011-03-01
DOI10.1007/s12015-010-9168-8
7期:1页:195-207
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell & Tissue Engineering ; Cell Biology ; Medicine, Research & Experimental
研究领域[WOS]Cell Biology ; Research & Experimental Medicine
关键词[WOS]HEPATOCYTE-LIKE CELLS ; INSULIN-PRODUCING CELLS ; MARROW STROMAL CELLS ; NEURONS IN-VITRO ; BONE-MARROW ; SPINAL-CORD ; PROGENITOR CELLS ; FUNCTIONAL RECOVERY ; PARKINSONS-DISEASE ; ENDOTHELIAL-CELLS
英文摘要

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs), isolated from discarded extra-embryonic tissue after birth, are promising candidate source of mesenchymal stem cells (MSCs). Apart from their prominent advantages in abundant supply, painless collection, and faster self-renewal, hUC-MSCs have shown the potencies to differentiate into a variety of cells of three germ layers (such as bone, cartilage, adipose, skeletal muscle, cardiomyocyte, endothelium, hepatocyte-like cluster, islet-like cluster, neuron, astrocyte and oligodendrocyte), to synthesize and secret a set of trophic factors and cytokines, to support the expansion and function of other cells (like hematopoietic stem cells, embryonic stem cells, natural killer cells, islet-like cell clusters, neurons and glial cells) , to migrate toward and home to pathological areas, and to be readily transfected with conventional methods. Two excellent previous reviews documenting the characteristics of this cell population with special emphasis on its niche, isolation, surface markers and primitive properties have been published recently. In this review, we will firstly give a brief introduction of this cell population, and subsequently dwell on the findings of differential capacities with emphasis on its therapeutic potentials.

语种英语
WOS记录号WOS:000286465200017
引用统计
被引频次:111[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56976
专题北京大学第二临床医学院_神经外科
作者单位Peking Univ, Peoples Hosp, Dept Neurosurg, Beijing 100871, Peoples R China
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GB/T 7714
Fan, Cun-Gang,Zhang, Qing-jun,Zhou, Jing-ru. Therapeutic Potentials of Mesenchymal Stem Cells Derived from Human Umbilical Cord[J]. STEM CELL REVIEWS AND REPORTS,2011,7(1):195-207.
APA Fan, Cun-Gang,Zhang, Qing-jun,&Zhou, Jing-ru.(2011).Therapeutic Potentials of Mesenchymal Stem Cells Derived from Human Umbilical Cord.STEM CELL REVIEWS AND REPORTS,7(1),195-207.
MLA Fan, Cun-Gang,et al."Therapeutic Potentials of Mesenchymal Stem Cells Derived from Human Umbilical Cord".STEM CELL REVIEWS AND REPORTS 7.1(2011):195-207.
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