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学科主题临床医学
Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells
Cao, Baoshan1; Jia, Jun3; Ma, Liwen1; Di, Lijun3; Song, Guohong3; Yuan, Yanhua3; Ma, Bo3; Zhu, Yulin3; Yu, Jing3; Wang, Xiaoli3; Zhou, Xinna3; Lyerly, H. Kim2; Ren, Jun3
关键词Non-small Cell Lung Cancer Side Population Angiogenesis
刊名CLINICAL & TRANSLATIONAL ONCOLOGY
2012-08-01
DOI10.1007/s12094-012-0844-9
14期:8页:575-585
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; PANCREATIC ADENOCARCINOMA CELLS ; ACUTE MYELOID-LEUKEMIA ; DRUG EFFLUX CAPACITY ; STEM-CELLS ; SIDE-POPULATION ; IN-VIVO ; TUMOR ANGIOGENESIS ; SIGNALING PATHWAY ; GENE-EXPRESSION
英文摘要

To ascertain the biologic significance of lung cancer Side population (SP) cells, which represent putative cancer stem cells (CSC) in the absence of consensus biomarkers for tumor-specific CSC.

We sorted and analyzed the angiogenic features of SP cells, isolated from tumor cell lines based on the exclusion of the DNA dye Hoechst 33342, from the NSCLC cell lines A549 and H460.

Compared with non-SP cells, mRNA of vascular endothelial growth factor (VEGF)-A, VEGF-B, angiopoietin (ang)-1, ang-2, fibroblast growth factor-2 (FGF-2), cyclooxygenase-2 (Cox-2) and interleukin-8 (IL-8) were over-expressed in SP cells accompanied by over-expression of ABCG2 and MDR1 mRNA. The supernatant of cultured SP cells could significantly induce migration of human umbilical vein endothelial cells, while recombinant human endostatin (Endostar 25(A (R))) could inhibit the migration.

This study revealed that the NSCLC SP cells might represent CSCs and possess pro-angiogenic properties, and antiangiogenesis represent a potential therapy.

语种英语
WOS记录号WOS:000307985000004
项目编号2009CB521700 ; 30471995
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56983
专题北京大学第三临床医学院_肿瘤放疗科
北京大学公共卫生学院_妇女与儿童青少年卫生学系
北京大学第三临床医学院_肿瘤治疗中心
北京大学临床肿瘤学院_乳腺肿瘤内科
北京大学临床肿瘤学院_移植与免疫治疗病区
北京大学临床肿瘤学院_生物诊断与治疗中心
作者单位1.Peking Univ Third Hosp, Dept Oncol, Beijing 100191, Peoples R China
2.Duke Univ, Med Ctr, Duke Comprehens Canc Ctr, Durham, NC 27710 USA
3.Peking Univ, Sch Oncol, Dept Med Oncol,Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Cao, Baoshan,Jia, Jun,Ma, Liwen,et al. Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells[J]. CLINICAL & TRANSLATIONAL ONCOLOGY,2012,14(8):575-585.
APA Cao, Baoshan.,Jia, Jun.,Ma, Liwen.,Di, Lijun.,Song, Guohong.,...&Ren, Jun.(2012).Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells.CLINICAL & TRANSLATIONAL ONCOLOGY,14(8),575-585.
MLA Cao, Baoshan,et al."Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells".CLINICAL & TRANSLATIONAL ONCOLOGY 14.8(2012):575-585.
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