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学科主题: 临床医学
题名:
Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells
作者: Cao, Baoshan1; Jia, Jun3; Ma, Liwen1; Di, Lijun3; Song, Guohong3; Yuan, Yanhua3; Ma, Bo3; Zhu, Yulin3; Yu, Jing3; Wang, Xiaoli3; Zhou, Xinna3; Lyerly, H. Kim2; Ren, Jun3
关键词: Non-small cell lung cancer ; Side population ; Angiogenesis
刊名: CLINICAL & TRANSLATIONAL ONCOLOGY
发表日期: 2012-08-01
DOI: 10.1007/s12094-012-0844-9
卷: 14, 期:8, 页:575-585
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; PANCREATIC ADENOCARCINOMA CELLS ; ACUTE MYELOID-LEUKEMIA ; DRUG EFFLUX CAPACITY ; STEM-CELLS ; SIDE-POPULATION ; IN-VIVO ; TUMOR ANGIOGENESIS ; SIGNALING PATHWAY ; GENE-EXPRESSION
英文摘要:

To ascertain the biologic significance of lung cancer Side population (SP) cells, which represent putative cancer stem cells (CSC) in the absence of consensus biomarkers for tumor-specific CSC.

We sorted and analyzed the angiogenic features of SP cells, isolated from tumor cell lines based on the exclusion of the DNA dye Hoechst 33342, from the NSCLC cell lines A549 and H460.

Compared with non-SP cells, mRNA of vascular endothelial growth factor (VEGF)-A, VEGF-B, angiopoietin (ang)-1, ang-2, fibroblast growth factor-2 (FGF-2), cyclooxygenase-2 (Cox-2) and interleukin-8 (IL-8) were over-expressed in SP cells accompanied by over-expression of ABCG2 and MDR1 mRNA. The supernatant of cultured SP cells could significantly induce migration of human umbilical vein endothelial cells, while recombinant human endostatin (Endostar 25(A (R))) could inhibit the migration.

This study revealed that the NSCLC SP cells might represent CSCs and possess pro-angiogenic properties, and antiangiogenesis represent a potential therapy.

语种: 英语
所属项目编号: 2009CB521700 ; 30471995
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China
WOS记录号: WOS:000307985000004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56983
Appears in Collections:北京大学第三临床医学院_肿瘤放疗科_期刊论文

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作者单位: 1.Peking Univ Third Hosp, Dept Oncol, Beijing 100191, Peoples R China
2.Duke Univ, Med Ctr, Duke Comprehens Canc Ctr, Durham, NC 27710 USA
3.Peking Univ, Sch Oncol, Dept Med Oncol,Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Cao, Baoshan,Jia, Jun,Ma, Liwen,et al. Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells[J]. CLINICAL & TRANSLATIONAL ONCOLOGY,2012,14(8):575-585.
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