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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Platelet Engraftment in Patients with Hematologic Malignancies following Unmanipulated Haploidentical Blood and Marrow Transplantation: Effects of CD34(+) Cell Dose and Disease Status
作者: Chang, Ying-Jun; Xu, Lan-Ping; Liu, Dai-Hong; Liu, Kai-Yan; Han, Wei; Chen, Yu-Hong; Yu-Wang; Chen, Huan; Wang, Jing-Zhi; Zhang, Xiao-Hui; Zhao, Xiang-Yu; Huang, Xiao-Jun
关键词: Engraftment ; CD34(+) cell ; Disease stage ; Unmanipulated blood and marrow transplantation
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2009-05-01
DOI: 10.1016/j.bbmt.2009.02.001
卷: 15, 期:5, 页:632-638
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: COLONY-STIMULATING FACTOR ; VERSUS-HOST-DISEASE ; IDENTICAL SIBLING TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSION ; ACUTE MYELOID-LEUKEMIA ; PERIPHERAL-BLOOD ; BONE-MARROW ; STEM-CELLS ; CHRONIC GRAFT ; ALLOGENEIC TRANSPLANTATION
英文摘要:

Unmanipulated haploidentical blood and marrow transplantation has been developed as an alternative transplantation strategy for patients without an HILA-matched related or unrelated donor. In this transplantation setting, factors associated with hematopoietic recovery have not been defined completely. The aim of this study was to investigate the effects of donor and recipient characteristics on neutrophil and platelet engraftment after unmanipulated HSCT The study group comprised 348 patients who underwent unmanipulated haploidentical blood and marrow transplantation to treat hematologic malignancy at a single institution between 2002 and 2007. Factors correlating with neutrophil and platelet engraftment posttransplantation were analyzed retrospectively. All patients achieved an absolute neutrophil count ANC of 500/mu L in a median of 13 days (range, 9 to 49 days). Of the 348 patients, 331 (95.11%) achieved an untransfused platelet count of > 20,000/mu L in a median of 16 days (range, 7 to 356 days). Multivariate analysis showed that the amount of CD34(+) cells infused (CD34(+) cells >= 2.19 x 10(6)/kg recipient weight vs < 2.19 X 10(6)/kg recipient weight; hazard ratio [HR] = 1.695; 95% confidence interval [CI] = 1.361 to 2.112; P < .0001), and disease stage (advanced vs early; HR = 0.724; 95% CI = 0.577 to 0.907; P = .005) were independently associated with increased risk of platelet engraftment. Our results suggest that low numbers of CD34+ cells in allografts and advanced-stage disease may be critical factors associated with delayed platelet engraftment after unmanipulated haploidentical transplantation.

语种: 英语
所属项目编号: 30725038 ; 2005-1010 ; IRT0702
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; Scientific Research Fund for Capital Medicine Development ; Program for Innovative Research Team in University
WOS记录号: WOS:000265445700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56984
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Chang, Ying-Jun,Xu, Lan-Ping,Liu, Dai-Hong,et al. Platelet Engraftment in Patients with Hematologic Malignancies following Unmanipulated Haploidentical Blood and Marrow Transplantation: Effects of CD34(+) Cell Dose and Disease Status[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2009,15(5):632-638.
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