IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
Platelet Engraftment in Patients with Hematologic Malignancies following Unmanipulated Haploidentical Blood and Marrow Transplantation: Effects of CD34(+) Cell Dose and Disease Status
Chang, Ying-Jun; Xu, Lan-Ping; Liu, Dai-Hong; Liu, Kai-Yan; Han, Wei; Chen, Yu-Hong; Yu-Wang; Chen, Huan; Wang, Jing-Zhi; Zhang, Xiao-Hui; Zhao, Xiang-Yu; Huang, Xiao-Jun
关键词Engraftment Cd34(+) Cell Disease Stage Unmanipulated Blood And Marrow Transplantation
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2009-05-01
DOI10.1016/j.bbmt.2009.02.001
15期:5页:632-638
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]COLONY-STIMULATING FACTOR ; VERSUS-HOST-DISEASE ; IDENTICAL SIBLING TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSION ; ACUTE MYELOID-LEUKEMIA ; PERIPHERAL-BLOOD ; BONE-MARROW ; STEM-CELLS ; CHRONIC GRAFT ; ALLOGENEIC TRANSPLANTATION
英文摘要

Unmanipulated haploidentical blood and marrow transplantation has been developed as an alternative transplantation strategy for patients without an HILA-matched related or unrelated donor. In this transplantation setting, factors associated with hematopoietic recovery have not been defined completely. The aim of this study was to investigate the effects of donor and recipient characteristics on neutrophil and platelet engraftment after unmanipulated HSCT The study group comprised 348 patients who underwent unmanipulated haploidentical blood and marrow transplantation to treat hematologic malignancy at a single institution between 2002 and 2007. Factors correlating with neutrophil and platelet engraftment posttransplantation were analyzed retrospectively. All patients achieved an absolute neutrophil count ANC of 500/mu L in a median of 13 days (range, 9 to 49 days). Of the 348 patients, 331 (95.11%) achieved an untransfused platelet count of > 20,000/mu L in a median of 16 days (range, 7 to 356 days). Multivariate analysis showed that the amount of CD34(+) cells infused (CD34(+) cells >= 2.19 x 10(6)/kg recipient weight vs < 2.19 X 10(6)/kg recipient weight; hazard ratio [HR] = 1.695; 95% confidence interval [CI] = 1.361 to 2.112; P < .0001), and disease stage (advanced vs early; HR = 0.724; 95% CI = 0.577 to 0.907; P = .005) were independently associated with increased risk of platelet engraftment. Our results suggest that low numbers of CD34+ cells in allografts and advanced-stage disease may be critical factors associated with delayed platelet engraftment after unmanipulated haploidentical transplantation.

语种英语
WOS记录号WOS:000265445700013
项目编号30725038 ; 2005-1010 ; IRT0702
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; Scientific Research Fund for Capital Medicine Development ; Program for Innovative Research Team in University
引用统计
被引频次:39[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56984
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Chang, Ying-Jun,Xu, Lan-Ping,Liu, Dai-Hong,et al. Platelet Engraftment in Patients with Hematologic Malignancies following Unmanipulated Haploidentical Blood and Marrow Transplantation: Effects of CD34(+) Cell Dose and Disease Status[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2009,15(5):632-638.
APA Chang, Ying-Jun.,Xu, Lan-Ping.,Liu, Dai-Hong.,Liu, Kai-Yan.,Han, Wei.,...&Huang, Xiao-Jun.(2009).Platelet Engraftment in Patients with Hematologic Malignancies following Unmanipulated Haploidentical Blood and Marrow Transplantation: Effects of CD34(+) Cell Dose and Disease Status.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,15(5),632-638.
MLA Chang, Ying-Jun,et al."Platelet Engraftment in Patients with Hematologic Malignancies following Unmanipulated Haploidentical Blood and Marrow Transplantation: Effects of CD34(+) Cell Dose and Disease Status".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 15.5(2009):632-638.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chang, Ying-Jun]的文章
[Xu, Lan-Ping]的文章
[Liu, Dai-Hong]的文章
百度学术
百度学术中相似的文章
[Chang, Ying-Jun]的文章
[Xu, Lan-Ping]的文章
[Liu, Dai-Hong]的文章
必应学术
必应学术中相似的文章
[Chang, Ying-Jun]的文章
[Xu, Lan-Ping]的文章
[Liu, Dai-Hong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。