北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 毒理学系  > 期刊论文
学科主题: 公共卫生
题名:
Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis
作者: Li, M; Xia, T; Jiang, CS; Li, LJ; Fu, JL; Zhou, ZC
关键词: cadmium ; mitochondria ; membrane permeability transition pore (PTP) ; apoptosis
刊名: TOXICOLOGY
发表日期: 2003-12-15
DOI: 10.1016/S0300-483X(03)00327-5
卷: 194, 期:1-2, 页:19-33
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: ADENINE-NUCLEOTIDE TRANSLOCASE ; CELL-DEATH ; TRANSITION PORE ; CYTOCHROME-C ; BCL-2 FAMILY ; RELEASE ; GLUTATHIONE ; BINDING ; COPPER ; HEPATOTOXICITY
英文摘要:

The mitochondrial damage induced by cadmium has been well established, but its mechanism and its relationship with cadmium-induced apoptosis are elusive until now. Our research showed that cadmium could directly lead to the dysfunction of isolated mitochondria from mouse liver, including the inhibition of respiration, the opening of permeability transition pore (PTP). the loss of transmembrane potential, and the release of cytochrome c. These mitochondrial changes were completely suppressed by Bcl-X-L and Ruthenium Red (RR). Bongkrekic acid (BK), an inhibitor of the PTP opening directly via adenine nucleotide translocator (ANT), also completely inhibited the PTP opening and loss of transmembrane potential. However, cyclosporin A (CsA), another inhibitor of the PTP opening indirectly via ANT, had not any inhibitory effect. When cadmium being pre-incubated with proteins containing abundant thiol groups, its effect was partially reversed. These results revealed that mitochondria pathway may involve in cadmium-induced apoptosis, and cadmium caused the PTP opening possibly through its binding to thiol groups of ANT. Furthermore, the mechanism of the PTP opening induced by cadmium was probably distinct from that of the calcium-induced PTP opening. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000187013500002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56989
Appears in Collections:北京大学公共卫生学院_毒理学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Toxicol, Beijing 100083, Peoples R China
2.Acad Sinica, Inst Zool, Natl Key Lab Biomembrane & Membrane Biotechnol, Beijing 100080, Peoples R China
3.Peking Univ, Coll Life Sci, Dept Physiol & Biophys, Beijing 100083, Peoples R China

Recommended Citation:
Li, M,Xia, T,Jiang, CS,et al. Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis[J]. TOXICOLOGY,2003,194(1-2):19-33.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, M]'s Articles
[Xia, T]'s Articles
[Jiang, CS]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, M]‘s Articles
[Xia, T]‘s Articles
[Jiang, CS]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace