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Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis
Li, M; Xia, T; Jiang, CS; Li, LJ; Fu, JL; Zhou, ZC
关键词Cadmium Mitochondria Membrane Permeability Transition Pore (Ptp) Apoptosis
刊名TOXICOLOGY
2003-12-15
DOI10.1016/S0300-483X(03)00327-5
194期:1-2页:19-33
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]ADENINE-NUCLEOTIDE TRANSLOCASE ; CELL-DEATH ; TRANSITION PORE ; CYTOCHROME-C ; BCL-2 FAMILY ; RELEASE ; GLUTATHIONE ; BINDING ; COPPER ; HEPATOTOXICITY
英文摘要

The mitochondrial damage induced by cadmium has been well established, but its mechanism and its relationship with cadmium-induced apoptosis are elusive until now. Our research showed that cadmium could directly lead to the dysfunction of isolated mitochondria from mouse liver, including the inhibition of respiration, the opening of permeability transition pore (PTP). the loss of transmembrane potential, and the release of cytochrome c. These mitochondrial changes were completely suppressed by Bcl-X-L and Ruthenium Red (RR). Bongkrekic acid (BK), an inhibitor of the PTP opening directly via adenine nucleotide translocator (ANT), also completely inhibited the PTP opening and loss of transmembrane potential. However, cyclosporin A (CsA), another inhibitor of the PTP opening indirectly via ANT, had not any inhibitory effect. When cadmium being pre-incubated with proteins containing abundant thiol groups, its effect was partially reversed. These results revealed that mitochondria pathway may involve in cadmium-induced apoptosis, and cadmium caused the PTP opening possibly through its binding to thiol groups of ANT. Furthermore, the mechanism of the PTP opening induced by cadmium was probably distinct from that of the calcium-induced PTP opening. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000187013500002
引用统计
被引频次:90[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56989
专题北京大学公共卫生学院_毒理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Toxicol, Beijing 100083, Peoples R China
2.Acad Sinica, Inst Zool, Natl Key Lab Biomembrane & Membrane Biotechnol, Beijing 100080, Peoples R China
3.Peking Univ, Coll Life Sci, Dept Physiol & Biophys, Beijing 100083, Peoples R China
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GB/T 7714
Li, M,Xia, T,Jiang, CS,et al. Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis[J]. TOXICOLOGY,2003,194(1-2):19-33.
APA Li, M,Xia, T,Jiang, CS,Li, LJ,Fu, JL,&Zhou, ZC.(2003).Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis.TOXICOLOGY,194(1-2),19-33.
MLA Li, M,et al."Cadmium directly induced the opening of membrane permeability pore of mitochondria which possibly involved in cadmium-triggered apoptosis".TOXICOLOGY 194.1-2(2003):19-33.
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