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Effect of Marine Collagen Peptides on Physiological and Neurobehavioral Development of Male Rats with Perinatal Asphyxia
Xu, Linlin1; Dong, Wenhong1; Zhao, Jie1; Xu, Yajun1,2
关键词Marine Collagen Peptides Perinatal Asphyxia Neurobehavioral Development
刊名MARINE DRUGS
2015-06-01
DOI10.3390/md13063653
13期:6页:3653-3671
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]Brain-injury ; Antioxidative Peptides ; Functional-properties ; Protein Hydrolysate ; Bioactive Peptides ; Neonatal Anoxia ; Spatial Memory ; Hypothermia ; Behavior ; Stress
英文摘要

Asphyxia during delivery produces long-term deficits in brain development. We investigated the neuroprotective effects of marine collagen peptides (MCPs), isolated from Chum Salmon skin by enzymatic hydrolysis, on male rats with perinatal asphyxia (PA). PA was performed by immersing rat fetuses with uterine horns removed from ready-to-deliver rats into a water bath for 15 min. Caesarean-delivered pups were used as controls. PA rats were intragastrically administered with 0.33 g/kg, 1.0 g/kg and 3.0 g/kg body weight MCPs from postnatal day 0 (PND 0) till the age of 90-days. Behavioral tests were carried out at PND21, PND 28 and PND 90. The results indicated that MCPs facilitated early body weight gain of the PA pups, however had little effects on early physiological development. Behavioral tests revealed that MCPs facilitated long-term learning and memory of the pups with PA through reducing oxidative damage and acetylcholinesterase (AChE) activity in the brain, and increasing hippocampus phosphorylated cAMP-response element binding protein (p-CREB) and brain derived neurotrophic factor (BDNF) expression.

语种英语
WOS记录号WOS:000357279900024
通讯作者邮箱xuyajun@bjmu.edu.cn
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56991
专题北京大学公共卫生学院
北京大学公共卫生学院_营养与食品卫生学系
作者单位1.Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China
2.Peking Univ, Beijing Key Lab Toxicol Res & Risk Assessment Foo, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xu, Linlin,Dong, Wenhong,Zhao, Jie,et al. Effect of Marine Collagen Peptides on Physiological and Neurobehavioral Development of Male Rats with Perinatal Asphyxia[J]. MARINE DRUGS,2015,13(6):3653-3671.
APA Xu, Linlin,Dong, Wenhong,Zhao, Jie,&Xu, Yajun.(2015).Effect of Marine Collagen Peptides on Physiological and Neurobehavioral Development of Male Rats with Perinatal Asphyxia.MARINE DRUGS,13(6),3653-3671.
MLA Xu, Linlin,et al."Effect of Marine Collagen Peptides on Physiological and Neurobehavioral Development of Male Rats with Perinatal Asphyxia".MARINE DRUGS 13.6(2015):3653-3671.
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