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学科主题: 基础医学
题名:
Chronic morphine-induced neuronal morphological changes in the ventral tegmental area in rats are reversed by electroacupuncture treatment
作者: Chu, Ning-ning; Xia, Wei; Yu, Peng; Hu, Ling; Zhang, Rong; Cui, Cai-Lian
关键词: electroacupuncture (EA) ; morphine dependence ; morphine withdrawal ; neuronal morphological changes ; ventral tegmental area (VTA) ; rat
刊名: ADDICTION BIOLOGY
发表日期: 2008-03-01
DOI: 10.1111/j.1369-1600.2007.00092.x
卷: 13, 期:1, 页:47-51
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Substance Abuse
研究领域[WOS]: Biochemistry & Molecular Biology ; Substance Abuse
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; COCAINE ADDICTION ; DOPAMINE NEURONS ; WITHDRAWAL ; ACUPUNCTURE ; MECHANISMS ; REDUCTION ; OPIOIDS ; HEROIN ; OPIATE
英文摘要:

The aim of this study was to observe the effect of electroacupuncture (EA) on chronic morphine-induced neuronal morphological changes in the ventral tegmental area (VTA) in rats at electron-microscopic level. Fourteen days of administering escalating doses of morphine induced pathological morphological changes of neurons in the VTA: the rough endoplasmic reticulum swelled, membrane configuration of the nucleus and mitochondria blurred, and structure of myelin sheath changed. Both 2 and 100 Hz EA treatment reversed the morphological alterations induced by chronic morphine administration. The findings provide new evidence that EA may serve as a potential therapy in treating opiate addiction.

语种: 英语
WOS记录号: WOS:000252927900006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56993
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Neurobiol, Beijing, Peoples R China

Recommended Citation:
Chu, Ning-ning,Xia, Wei,Yu, Peng,et al. Chronic morphine-induced neuronal morphological changes in the ventral tegmental area in rats are reversed by electroacupuncture treatment[J]. ADDICTION BIOLOGY,2008,13(1):47-51.
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