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学科主题基础医学
Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model
Hou, Yan2; Shao, Wanfang1; Xiao, Rong3; Xu, Kunlong3; Ma, Zhizhong4; Johnstone, Brian H.5; Du, Yansheng6
关键词Pu-erh Tea Hyperlipidemia Obesity Serum Lipid Lipid Peroxidation
刊名EXPERIMENTAL GERONTOLOGY
2009-06-01
DOI10.1016/j.exger.2009.03.007
44期:6-7页:434-439
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Geriatrics & Gerontology
研究领域[WOS]Geriatrics & Gerontology
关键词[WOS]SUPEROXIDE-DISMUTASE ; CARBON-TETRACHLORIDE ; HEALTH-BENEFITS ; GREEN TEA ; GSH-PX ; POLYPHENOLS ; ASSAY ; ACID ; BLOOD ; BLACK
英文摘要

Pu-erh tea is believed to possess many beneficial health effects since it is a natural source of cardioprotective lipid lowering and antioxidant compounds, although, the major constituents putatively responsible for these beneficial effects remain unknown. In this study, we examined the effects of two commonly consumed forms of Pu-erh tea, fermented and unfermented, on weight gain, serum levels of lipids and lipoprotein, lipid oxidation, and blood antioxidant enzymes in a rat hyperlipidemia model. Hyperlipidemic rats were treated with water extracts of either 0.5, 1.5 or 3.0 mg/kg fermented or unfermented Pu-erh tea. Serum low density lipoprotein-cholesterol (LDL-C) and triglyceride levels were significantly lowered by tea extract compared to the control group. (p < 0.05) and in most cases were indistinguishable from rats fed normal chow, basal diet. Conversely, levels of high density lipoprotein-cholesterol (HDL-C) were elevated in the groups given daily doses of tea extract (p < 0.05). Compared to the hyperlipidemic control group, activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum were significantly elevated in Pu-erh tea-treated groups while levels of malondiadehyde (a byproduct of lipid peroxidation) decreased in the same groups. These effects were most pronounced in the groups treated with the highest dose of fermented Pu-erh tea extract. Our results suggest that Pu-erh tea exerts strong antioxidative and lipid-lowering effects and therefore can be used to reduce the risk of cardiovascular disorders. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000267584900012
项目编号2007BAD581304 ; 2007YNCXB-01-01
资助机构National Key Technology R&amp ; D Program of the People&prime ; s Republic of China ; Office of Biological Resources Innovation of Yunnan province
引用统计
被引频次:70[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56995
专题北京大学基础医学院
作者单位1.Yunnan Agr Univ, Coll Long Run Pu Erh Tea, Kunming 650201, Yunnan, Peoples R China
2.Certificate Assessment Ctr Yunnan Pu Erh Tea, Kunming 650201, Yunnan, Peoples R China
3.Yunnan Agr Univ, Coll Anim Sci & Technol, Kunming 650201, Yunnan, Peoples R China
4.Peking Univ, Basic Med Sch, Beijing 100083, Peoples R China
5.Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA
6.Indiana Univ, Sch Med, Dept Neurol, Indianapolis, IN 46202 USA
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GB/T 7714
Hou, Yan,Shao, Wanfang,Xiao, Rong,et al. Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model[J]. EXPERIMENTAL GERONTOLOGY,2009,44(6-7):434-439.
APA Hou, Yan.,Shao, Wanfang.,Xiao, Rong.,Xu, Kunlong.,Ma, Zhizhong.,...&Du, Yansheng.(2009).Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model.EXPERIMENTAL GERONTOLOGY,44(6-7),434-439.
MLA Hou, Yan,et al."Pu-erh tea aqueous extracts lower atherosclerotic risk factors in a rat hyperlipidemia model".EXPERIMENTAL GERONTOLOGY 44.6-7(2009):434-439.
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