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学科主题: 临床医学
题名:
Long-term treatment by ACE inhibitors and angiotensin receptor blockers in children with Alport syndrome
作者: Zhang, Yanqin1; Wang, Fang1; Ding, Jie1; Zhang, Hongwen1; Liu, Xiaoyu1; Wang, Suxia2; Xiao, Huijie1; Yao, Yong1; Liu, Jingcheng1; Zhong, Xuhui1; Guan, Na1; Su, Baige1; Wu, Guohong1; Yu, Lixia1
关键词: Alport syndrome ; Children ; Proteinuria ; ACE inhibitor ; Angiotensin receptor blocker
刊名: PEDIATRIC NEPHROLOGY
发表日期: 2016
DOI: 10.1007/s00467-015-3184-5
卷: 31, 期:1, 页:67-72
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pediatrics ; Urology & Nephrology
研究领域[WOS]: Pediatrics ; Urology & Nephrology
关键词[WOS]: GENOTYPE-PHENOTYPE CORRELATIONS ; ENALAPRIL ; IDENTIFICATION ; PROTEINURIA ; MUTATIONS ; LOSARTAN
英文摘要:

The aim of this study was to analyze the long-term efficacy and safety of angiotensin-converting enzyme inhibitor (ACEi) and ACEi + angiotensin receptor blocker (ARB) treatments in a cohort of children with Alport syndrome (AS).

This was a respective review of 79 Chinese children with AS who received ACEi alone or combined ACEi + ARB therapy.

The mean age of the pediatric patients with AS at onset of treatment was 8.6 +/- 4.1 (range 1.5-16.3) years. The mean duration of follow-up was 2.5 +/- 1.8 (range 0.5-7.8) years. For analysis, we separated the children into three groups according to proteinuria level before treatment, namely, < 25, 25-50, and a parts per thousand yen50 mg/kg/day, respectively; after 1 year of treatment the proteinuria had decreased from 11.0 to 9.7 mg/kg/day, from 34.6 to 15.2 mg/kg/day, and from 73.0 to 50.0 mg/kg/day in each group, respectively. Proteinuria decreased significantly during the first 2 years of treatment and was stable from the third to fifth years of treatment. There was no statistically significant difference in the antiproteinuric effect of the ACEi and ACEi + ARB treatments in patients with severe or less severe mutations after 1 year of therapy. Five children stopped the ACEi + ARB treatment due to a decline in creatinine clearance.

Our findings demonstrate that early and long-term ACEi and ARB treatments in children with AS is efficient and well tolerated. The antiproteinuric effect of ACEi and ARB is of equal value in children with severe and less severe mutations in the COL4An gene.

语种: 英语
所属项目编号: 30801252 81070545 ; 81400685 ; 7102148 ; 2012BAI03B02
项目资助者: National Nature Science Foundation ; Beijing Nature Science Foundation ; National "Twelfth Five-Year" Science and Technology Support Project
WOS记录号: WOS:000365100500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56998
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Dept Electron Microscopy, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Yanqin,Wang, Fang,Ding, Jie,et al. Long-term treatment by ACE inhibitors and angiotensin receptor blockers in children with Alport syndrome[J]. PEDIATRIC NEPHROLOGY,2016,31(1):67-72.
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