IR@PKUHSC  > 基础医学院  > 北京大学感染病研究中心
学科主题基础医学
Pathogenetic mechanisms of severe acute respiratory syndrome
Guo, Yong; Korteweg, Christine; McNutt, Michael A.; Gu, Jiang
关键词SARS pathology immune system virus lung
刊名VIRUS RESEARCH
2008-04-01
DOI10.1016/j.virusres.2007.01.022
133期:1页:4-12
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]SYNDROME-ASSOCIATED CORONAVIRUS ; ANGIOTENSIN-CONVERTING ENZYME-2 ; SARS-ASSOCIATED CORONAVIRUS ; IN-SITU HYBRIDIZATION ; FUNCTIONAL RECEPTOR ; EPITHELIAL-CELLS ; LUNG PATHOLOGY ; L-SIGN ; INFECTION ; PROTEIN
英文摘要

Severe acute respiratory syndrome (SARS) is an acute respiratory disease with significant morbidity and mortality. While its clinical manifestations have been extensively studied, its pathogenesis is not yet fully understood. A limited number of autopsy studies have revealed that the lungs and the immune system are the organs that sustain the most severe damage. Other organs affected include the kidneys, brain, digestive tract, heart. liver, thyroid gland and urogenital tract. The primary target cells are pneumocytes and enterocytes, both cell types abundantly expressing angiotensin-converting enzyme 2 which is the main SARS-CoV receptor. Other cell types infected include the epithelial cells of renal tubules, cerebral neurons, and immune cells. The pathology of this disease results from both direct and indirect injury. Direct injury is caused by infection of the tar-et cells by the virus. Indirect injury mainly results from immune responses, circulatory dysfunction, and hypoxia. In this review, we summarize the major pathological findings at the gross, cellular and molecular levels and discuss the various possible mechanisms that may contribute to the pathogenesis of SARS. The implications of the proposed pathogenesis for prevention, diagnosis and therapy of the disease are discussed. (C) 2007 Published by Elsevier B.V.

语种英语
WOS记录号WOS:000255145400002
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57005
专题基础医学院_北京大学感染病研究中心
作者单位Peking Univ, Ctr Infect Dis, Sch Med Sci, Dept Pathol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Guo, Yong,Korteweg, Christine,McNutt, Michael A.,et al. Pathogenetic mechanisms of severe acute respiratory syndrome[J]. VIRUS RESEARCH,2008,133(1):4-12.
APA Guo, Yong,Korteweg, Christine,McNutt, Michael A.,&Gu, Jiang.(2008).Pathogenetic mechanisms of severe acute respiratory syndrome.VIRUS RESEARCH,133(1),4-12.
MLA Guo, Yong,et al."Pathogenetic mechanisms of severe acute respiratory syndrome".VIRUS RESEARCH 133.1(2008):4-12.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Pathogenetic mechani(344KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Guo, Yong]的文章
[Korteweg, Christine]的文章
[McNutt, Michael A.]的文章
百度学术
百度学术中相似的文章
[Guo, Yong]的文章
[Korteweg, Christine]的文章
[McNutt, Michael A.]的文章
必应学术
必应学术中相似的文章
[Guo, Yong]的文章
[Korteweg, Christine]的文章
[McNutt, Michael A.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Pathogenetic mechanisms of severe acute respiratory syndrome.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。