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学科主题: 基础医学
题名:
Pathogenetic mechanisms of severe acute respiratory syndrome
作者: Guo, Yong; Korteweg, Christine; McNutt, Michael A.; Gu, Jiang
关键词: SARS ; pathology ; immune system ; virus ; lung
刊名: VIRUS RESEARCH
发表日期: 2008-04-01
DOI: 10.1016/j.virusres.2007.01.022
卷: 133, 期:1, 页:4-12
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: SYNDROME-ASSOCIATED CORONAVIRUS ; ANGIOTENSIN-CONVERTING ENZYME-2 ; SARS-ASSOCIATED CORONAVIRUS ; IN-SITU HYBRIDIZATION ; FUNCTIONAL RECEPTOR ; EPITHELIAL-CELLS ; LUNG PATHOLOGY ; L-SIGN ; INFECTION ; PROTEIN
英文摘要:

Severe acute respiratory syndrome (SARS) is an acute respiratory disease with significant morbidity and mortality. While its clinical manifestations have been extensively studied, its pathogenesis is not yet fully understood. A limited number of autopsy studies have revealed that the lungs and the immune system are the organs that sustain the most severe damage. Other organs affected include the kidneys, brain, digestive tract, heart. liver, thyroid gland and urogenital tract. The primary target cells are pneumocytes and enterocytes, both cell types abundantly expressing angiotensin-converting enzyme 2 which is the main SARS-CoV receptor. Other cell types infected include the epithelial cells of renal tubules, cerebral neurons, and immune cells. The pathology of this disease results from both direct and indirect injury. Direct injury is caused by infection of the tar-et cells by the virus. Indirect injury mainly results from immune responses, circulatory dysfunction, and hypoxia. In this review, we summarize the major pathological findings at the gross, cellular and molecular levels and discuss the various possible mechanisms that may contribute to the pathogenesis of SARS. The implications of the proposed pathogenesis for prevention, diagnosis and therapy of the disease are discussed. (C) 2007 Published by Elsevier B.V.

语种: 英语
WOS记录号: WOS:000255145400002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57005
Appears in Collections:基础医学院_北京大学感染病研究中心_期刊论文

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作者单位: Peking Univ, Ctr Infect Dis, Sch Med Sci, Dept Pathol, Beijing 100083, Peoples R China

Recommended Citation:
Guo, Yong,Korteweg, Christine,McNutt, Michael A.,et al. Pathogenetic mechanisms of severe acute respiratory syndrome[J]. VIRUS RESEARCH,2008,133(1):4-12.
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