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学科主题: 临床医学
题名:
Interferons Accelerate Decay of Replication-Competent Nucleocapsids of Hepatitis B Virus
作者: Xu, Chunxiao1; Guo, Haitao1; Pan, Xiao-Ben1; Mao, Richeng1; Yu, Wenquan2; Xu, Xiaodong2; Wei, Lai3,4; Chang, Jinhong1; Block, Timothy M.1,2; Guo, Ju-Tao1
刊名: JOURNAL OF VIROLOGY
发表日期: 2010-09-15
DOI: 10.1128/JVI.00918-10
卷: 84, 期:18, 页:9332-9340
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: CYTOTOXIC T-LYMPHOCYTES ; CORE PROTEIN ; TRANSGENIC MICE ; GENE-EXPRESSION ; PEGINTERFERON ALPHA-2A ; REVERSE TRANSCRIPTION ; HBV REPLICATION ; DANE PARTICLES ; E-ANTIGEN ; C VIRUS
英文摘要:

Alpha interferon (IFN-alpha) is an approved medication for chronic hepatitis B. Gamma interferon (IFN-gamma) is a key mediator of host antiviral immunity against hepatitis B virus (HBV) infection in vivo. However, the molecular mechanism by which these antiviral cytokines suppress HBV replication remains elusive. Using an immortalized murine hepatocyte (AML12)-derived cell line supporting tetracycline-inducible HBV replication, we show in this report that both IFN-alpha and IFN-gamma efficiently reduce the amount of intracellular HBV nucleocapsids. Furthermore, we provide evidence suggesting that the IFN-induced cellular antiviral response is able to distinguish and selectively accelerate the decay of HBV replication-competent nucleocapsids but not empty capsids in a proteasome-dependent manner. Our findings thus reveal a novel antiviral mechanism of IFNs and provide a basis for a better understanding of HBV pathobiology.

语种: 英语
所属项目编号: AI061441
项目资助者: National Institutes of Health ; Hepatitis B Foundation through Commonwealth of Pennsylvania
WOS记录号: WOS:000281110500034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57006
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Drexel Univ, Coll Med, Drexel Inst Biotechnol & Virol Res, Dept Microbiol & Immunol, Doylestown, PA 18902 USA
2.Hepatitis B Fdn, Inst Hepatitis & Virus Res, Doylestown, PA 18902 USA
3.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
4.Peking Univ, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Xu, Chunxiao,Guo, Haitao,Pan, Xiao-Ben,et al. Interferons Accelerate Decay of Replication-Competent Nucleocapsids of Hepatitis B Virus[J]. JOURNAL OF VIROLOGY,2010,84(18):9332-9340.
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