IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Interferons Accelerate Decay of Replication-Competent Nucleocapsids of Hepatitis B Virus
Xu, Chunxiao1; Guo, Haitao1; Pan, Xiao-Ben1; Mao, Richeng1; Yu, Wenquan2; Xu, Xiaodong2; Wei, Lai3,4; Chang, Jinhong1; Block, Timothy M.1,2; Guo, Ju-Tao1
刊名JOURNAL OF VIROLOGY
2010-09-15
DOI10.1128/JVI.00918-10
84期:18页:9332-9340
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
资助者National Institutes of Health ; Hepatitis B Foundation through Commonwealth of Pennsylvania ; National Institutes of Health ; Hepatitis B Foundation through Commonwealth of Pennsylvania
研究领域[WOS]Virology
关键词[WOS]CYTOTOXIC T-LYMPHOCYTES ; CORE PROTEIN ; TRANSGENIC MICE ; GENE-EXPRESSION ; PEGINTERFERON ALPHA-2A ; REVERSE TRANSCRIPTION ; HBV REPLICATION ; DANE PARTICLES ; E-ANTIGEN ; C VIRUS
英文摘要

Alpha interferon (IFN-alpha) is an approved medication for chronic hepatitis B. Gamma interferon (IFN-gamma) is a key mediator of host antiviral immunity against hepatitis B virus (HBV) infection in vivo. However, the molecular mechanism by which these antiviral cytokines suppress HBV replication remains elusive. Using an immortalized murine hepatocyte (AML12)-derived cell line supporting tetracycline-inducible HBV replication, we show in this report that both IFN-alpha and IFN-gamma efficiently reduce the amount of intracellular HBV nucleocapsids. Furthermore, we provide evidence suggesting that the IFN-induced cellular antiviral response is able to distinguish and selectively accelerate the decay of HBV replication-competent nucleocapsids but not empty capsids in a proteasome-dependent manner. Our findings thus reveal a novel antiviral mechanism of IFNs and provide a basis for a better understanding of HBV pathobiology.

语种英语
所属项目编号AI061441
资助者National Institutes of Health ; Hepatitis B Foundation through Commonwealth of Pennsylvania ; National Institutes of Health ; Hepatitis B Foundation through Commonwealth of Pennsylvania
WOS记录号WOS:000281110500034
Citation statistics
Cited Times:57[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57006
Collection北京大学第二临床医学院
作者单位1.Drexel Univ, Coll Med, Drexel Inst Biotechnol & Virol Res, Dept Microbiol & Immunol, Doylestown, PA 18902 USA
2.Hepatitis B Fdn, Inst Hepatitis & Virus Res, Doylestown, PA 18902 USA
3.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
4.Peking Univ, Inst Hepatol, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Xu, Chunxiao,Guo, Haitao,Pan, Xiao-Ben,et al. Interferons Accelerate Decay of Replication-Competent Nucleocapsids of Hepatitis B Virus[J]. JOURNAL OF VIROLOGY,2010,84(18):9332-9340.
APA Xu, Chunxiao.,Guo, Haitao.,Pan, Xiao-Ben.,Mao, Richeng.,Yu, Wenquan.,...&Guo, Ju-Tao.(2010).Interferons Accelerate Decay of Replication-Competent Nucleocapsids of Hepatitis B Virus.JOURNAL OF VIROLOGY,84(18),9332-9340.
MLA Xu, Chunxiao,et al."Interferons Accelerate Decay of Replication-Competent Nucleocapsids of Hepatitis B Virus".JOURNAL OF VIROLOGY 84.18(2010):9332-9340.
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