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Severe fever with thrombocytopenia syndrome in children: a case report
Wang, Li-Yuan1,2; Cui, Ning3; Lu, Qing-Bin4; Wo, Ying2; Wang, Hong-Yu1,2; Liu, Wei2; Cao, Wu-Chun2
关键词Severe Fever With Thrombocytopenia Syndrome Bunyavirus Children
刊名BMC INFECTIOUS DISEASES
2014-07-03
DOI10.1186/1471-2334-14-366
14
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]HEMORRHAGIC-FEVER ; BUNYAVIRUS ; CHINA ; PATHOGENESIS ; DISEASE
英文摘要

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus (SFTSV) in China. Humans of all ages living in endemic areas have high risk of acquiring SFTS. Most clinical data so far have been from adults and no clinical study was available from children yet. The present study identified four SFTSV infected children through hospital based surveillance. A prospective observational study was performed to obtain their clinical and laboratory characteristics.

Case presentation: The patients′ age ranged from 4-15 years old and two were male. On hospitalization, fever, malaise and gastrointestinal syndromes were the most commonly presenting symptoms. Hemorrhagic symptoms or neurological manifestation was not recorded in any of the four pediatric patients. Hematological abnormalities at admission into hospital included leucopenia (4 cases), thrombocytopenia (1 case) and bicytopenia (1 case). The abnormal parameters included elevated aminotransferase (1 case), alanine transaminase (2 case), and lactate dehydrogenase (3 case). Laboratory parameters indicative of renal damage was not observed during the hospitalization. All the patients recovered well without sequelae being observed.

Conclusion: Compared with adults, pediatric patients with SFTSV infection seem to have less vague subjective complaints and less aggressive clinical course. Thrombocytopenia is suggested to be used less rigorously in recognizing SFTSV infection in pediatric patients, especially at early phase of disease.

语种英语
WOS记录号WOS:000338795200001
项目编号2013ZX10004-202 ; 81222037 ; 81290344 ; 81130086
资助机构China Mega-Project for Infectious Diseases grant ; Natural Science Foundation of China
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57009
专题北京大学公共卫生学院
作者单位1.Anhui Med Univ, Grad Sch, Hefei 230032, Peoples R China
2.Peoples Liberat Army, Hosp 154, Xinyang 464000, Peoples R China
3.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
4.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
推荐引用方式
GB/T 7714
Wang, Li-Yuan,Cui, Ning,Lu, Qing-Bin,et al. Severe fever with thrombocytopenia syndrome in children: a case report[J]. BMC INFECTIOUS DISEASES,2014,14.
APA Wang, Li-Yuan.,Cui, Ning.,Lu, Qing-Bin.,Wo, Ying.,Wang, Hong-Yu.,...&Cao, Wu-Chun.(2014).Severe fever with thrombocytopenia syndrome in children: a case report.BMC INFECTIOUS DISEASES,14.
MLA Wang, Li-Yuan,et al."Severe fever with thrombocytopenia syndrome in children: a case report".BMC INFECTIOUS DISEASES 14(2014).
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