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学科主题: 公共卫生
题名:
Severe fever with thrombocytopenia syndrome in children: a case report
作者: Wang, Li-Yuan1,2; Cui, Ning3; Lu, Qing-Bin4; Wo, Ying2; Wang, Hong-Yu1,2; Liu, Wei2; Cao, Wu-Chun2
关键词: Severe fever with thrombocytopenia syndrome ; Bunyavirus ; Children
刊名: BMC INFECTIOUS DISEASES
发表日期: 2014-07-03
DOI: 10.1186/1471-2334-14-366
卷: 14
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: HEMORRHAGIC-FEVER ; BUNYAVIRUS ; CHINA ; PATHOGENESIS ; DISEASE
英文摘要:

Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus (SFTSV) in China. Humans of all ages living in endemic areas have high risk of acquiring SFTS. Most clinical data so far have been from adults and no clinical study was available from children yet. The present study identified four SFTSV infected children through hospital based surveillance. A prospective observational study was performed to obtain their clinical and laboratory characteristics.

Case presentation: The patients′ age ranged from 4-15 years old and two were male. On hospitalization, fever, malaise and gastrointestinal syndromes were the most commonly presenting symptoms. Hemorrhagic symptoms or neurological manifestation was not recorded in any of the four pediatric patients. Hematological abnormalities at admission into hospital included leucopenia (4 cases), thrombocytopenia (1 case) and bicytopenia (1 case). The abnormal parameters included elevated aminotransferase (1 case), alanine transaminase (2 case), and lactate dehydrogenase (3 case). Laboratory parameters indicative of renal damage was not observed during the hospitalization. All the patients recovered well without sequelae being observed.

Conclusion: Compared with adults, pediatric patients with SFTSV infection seem to have less vague subjective complaints and less aggressive clinical course. Thrombocytopenia is suggested to be used less rigorously in recognizing SFTSV infection in pediatric patients, especially at early phase of disease.

语种: 英语
所属项目编号: 2013ZX10004-202 ; 81222037 ; 81290344 ; 81130086
项目资助者: China Mega-Project for Infectious Diseases grant ; Natural Science Foundation of China
WOS记录号: WOS:000338795200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57009
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Anhui Med Univ, Grad Sch, Hefei 230032, Peoples R China
2.Peoples Liberat Army, Hosp 154, Xinyang 464000, Peoples R China
3.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
4.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China

Recommended Citation:
Wang, Li-Yuan,Cui, Ning,Lu, Qing-Bin,et al. Severe fever with thrombocytopenia syndrome in children: a case report[J]. BMC INFECTIOUS DISEASES,2014,14.
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