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学科主题: 基础医学
题名:
Meta-analysis of the association between anti-HBc seropositivity and a poor prognosis of chronic HCV infection
作者: Nan, Xiao1; Shi, Shuang1; Yu, Canqing2; Zhuang, Hui1
关键词: anti-HBc ; hepatitis C virus ; hepatocellular carcinoma ; liver cirrhosis
刊名: HEPATOLOGY RESEARCH
发表日期: 2010-12-01
DOI: 10.1111/j.1872-034X.2010.00733.x
卷: 40, 期:12, 页:1176-1187
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: B-VIRUS-INFECTION ; CHRONIC HEPATITIS-C ; HEPATOCELLULAR-CARCINOMA ; LIVER-DISEASE ; CORE ANTIGEN ; HIGH PREVALENCE ; RISK ; CIRRHOSIS ; MARKERS ; IMPACT
英文摘要:

Aim:

The impact of serological HBsAg- and anti-HBc+ on the prognosis of chronic hepatitis C virus (HCV) infection is unknown. We conducted a systematic review to analyze whether anti-HBc positivity imposes any effect on the course of HCV-related chronic liver disease.

Methods:

We retrieved references from online databases that included PubMed and EMBASE. Data were gathered with regard to demographic information, disease progression and prognosis, and the results of serological tests. The development of hepatocellular carcinoma (HCC) was the endpoint of follow-up of all cohort studies.

Results:

Eighteen references were included in this study, of which four were cohort studies. Twelve studies were retrospective, observational and non-interventional studies. According to our meta-analysis, the rate of serological HBsAg- and anti-HBc+ was higher among HCC patients compared with non-HCC patients (odds ratio [OR], 1.55; 95% CI, 1.22-1.98). HCV patients that were anti-HBc+ had a greater chance of developing HCC than their anti-HBc- counterparts (OR, 2.15; 95% CI, 1.34-3.47).

Conclusions:

The serological status of HBsAg- and anti-HBc+ appears to be correlated with a poor prognosis for chronic HCV infection. Though the general quality of these references was low, and multiple confounding factors existed, the likelihood of a poorer outcome of HCV patients that are positive for anti-HBc should be considered by their physicians.

语种: 英语
WOS记录号: WOS:000284893600004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57012
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Publ Hlth, Beijing, Peoples R China

Recommended Citation:
Nan, Xiao,Shi, Shuang,Yu, Canqing,et al. Meta-analysis of the association between anti-HBc seropositivity and a poor prognosis of chronic HCV infection[J]. HEPATOLOGY RESEARCH,2010,40(12):1176-1187.
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