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Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions
Huang, Wei1,2; Tang, Shunan2; Qiao, Xue1; Ma, Wanwan2; Ji, Shuai1; Wang, Kui1,2; Ye, Min1; Yu, Siwang2
关键词Isoangustone a Colorectal Cancer Apoptosis Mitochondrial Outer Membrane Permeabilization
刊名FITOTERAPIA
2014-04-01
DOI10.1016/j.fitote.2014.01.016
94页:36-47
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PROSTATE-CANCER CELLS ; DU145 HUMAN PROSTATE ; GLYCYRRHIZA-URALENSIS ; COLON-CANCER ; HEXANE/ETHANOL EXTRACT ; CYCLE ARREST ; LICORICE ; ISOLIQUIRITIGENIN ; PATHWAY ; CHEMOPREVENTION
英文摘要

Licorice and its components have been reported to posses various anti-tumor activities, but its active ingredients and underlying mechanisms are not well understood yet. In the present study, a group of representative licorice-derived compounds that could be detected in rat plasma or urine were screened for anti-tumor activity. Among these compounds, isoangustone A (IAA) was found to promptly Inhibit the viability of SW480 human colorectal adenocarcinoma cells in a time- and concentration-dependent manner. Further analyses indicate that IAA activated caspase-dependent pro-apoptotic signaling and induced significant apoptosis, while had little effect on cell cycle. IAA strongly inhibited Akt phosphorylation within 5 min; however, overexpression of constitutively activated Akt could not rescue IAA-mediated inhibition, indicating that inhibition of Akt was not involved in IAA-induced apoptosis. Further examinations show that IAA induced dissipation of mitochondria membrane potential and release of cytochrome C within 1 h, accompanied by swelling of mitochondrial matrix and disrupting of mitochondrial outer membrane, and followed by decreasing of cellular ATP. The above results suggest that IAA induced apoptosis in colorectal cancer cells principally by inducing mitochondrial outer membrane permeabilization, and deserves further investigations as a novel anti-colorectal cancer agent. (C) 2014 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000335608700005
项目编号21001011 ; 81173644 ; 81272468
资助机构National Natural Science Foundation of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57016
专题北京大学药学院
北京大学药学院_化学生物学系
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China
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GB/T 7714
Huang, Wei,Tang, Shunan,Qiao, Xue,et al. Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions[J]. FITOTERAPIA,2014,94:36-47.
APA Huang, Wei.,Tang, Shunan.,Qiao, Xue.,Ma, Wanwan.,Ji, Shuai.,...&Yu, Siwang.(2014).Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions.FITOTERAPIA,94,36-47.
MLA Huang, Wei,et al."Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions".FITOTERAPIA 94(2014):36-47.
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