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学科主题: 药学
题名:
Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions
作者: Huang, Wei1,2; Tang, Shunan2; Qiao, Xue1; Ma, Wanwan2; Ji, Shuai1; Wang, Kui1,2; Ye, Min1; Yu, Siwang2
关键词: Isoangustone A ; Colorectal cancer ; Apoptosis ; Mitochondrial outer membrane permeabilization
刊名: FITOTERAPIA
发表日期: 2014-04-01
DOI: 10.1016/j.fitote.2014.01.016
卷: 94, 页:36-47
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: PROSTATE-CANCER CELLS ; DU145 HUMAN PROSTATE ; GLYCYRRHIZA-URALENSIS ; COLON-CANCER ; HEXANE/ETHANOL EXTRACT ; CYCLE ARREST ; LICORICE ; ISOLIQUIRITIGENIN ; PATHWAY ; CHEMOPREVENTION
英文摘要:

Licorice and its components have been reported to posses various anti-tumor activities, but its active ingredients and underlying mechanisms are not well understood yet. In the present study, a group of representative licorice-derived compounds that could be detected in rat plasma or urine were screened for anti-tumor activity. Among these compounds, isoangustone A (IAA) was found to promptly Inhibit the viability of SW480 human colorectal adenocarcinoma cells in a time- and concentration-dependent manner. Further analyses indicate that IAA activated caspase-dependent pro-apoptotic signaling and induced significant apoptosis, while had little effect on cell cycle. IAA strongly inhibited Akt phosphorylation within 5 min; however, overexpression of constitutively activated Akt could not rescue IAA-mediated inhibition, indicating that inhibition of Akt was not involved in IAA-induced apoptosis. Further examinations show that IAA induced dissipation of mitochondria membrane potential and release of cytochrome C within 1 h, accompanied by swelling of mitochondrial matrix and disrupting of mitochondrial outer membrane, and followed by decreasing of cellular ATP. The above results suggest that IAA induced apoptosis in colorectal cancer cells principally by inducing mitochondrial outer membrane permeabilization, and deserves further investigations as a novel anti-colorectal cancer agent. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 21001011 ; 81173644 ; 81272468
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000335608700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57016
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China

Recommended Citation:
Huang, Wei,Tang, Shunan,Qiao, Xue,et al. Isoangustone A induces apoptosis in SW480 human colorectal adenocarcinoma cells by disrupting mitochondrial functions[J]. FITOTERAPIA,2014,94:36-47.
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