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学科主题: 临床医学
题名:
Effects of hydrogen sulfide on hypoxic pulmonary vascular structural remodeling
作者: Jin, HF; Cong, BL; Zhao, B; Zhang, CY; Liu, XM; Zhou, WJ; Shi, Y; Tang, CS; Du, JB
关键词: hydrogen sulfide ; hypoxia ; pulmonary vascular structural remodeling ; proliferative cell nuclear antigen ; urotensin II ; collagen ; elastin ; matrix metalloproteinase-l ; tissue inhibitors of metalloproteinease-1
刊名: LIFE SCIENCES
发表日期: 2006-02-16
DOI: 10.1016/j.lfs.2005.07.009
卷: 78, 期:12, 页:1299-1309
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: GROWTH-FACTOR-BETA ; NITRIC-OXIDE SYNTHASE ; HUMAN UROTENSIN-II ; CARBON-MONOXIDE ; HYPERTENSION ; RAT ; EXPRESSION ; HEART ; GENE ; INHIBITOR
英文摘要:

study the role of hydrogen sulfide (H2S) in hypoxic pulmonary vascular structural remodeling (HPVSR), a total of 24 Wistar rats were randomly divided into three groups: control group (n=8), hypoxia group (n=8) and hypoxia with sodium hydrosulfide (hy+NaHS) group (n=8). The mean pulmonary artery pressure (mPAP), plasma H2S and the percentage of muscularized arteries (MA), partially muscularized arteries (PMA) and nonmuscularized arteries (NMA) in small pulmonary vessels were measured. Collagen I and 111, elastin, transforming growth factor-beta(3) (TGF-beta(3)), proliferative cell nuclear antigen (PCNA) and human urotensin II(U-II) expressions were detected by immunohistochemical assay. The mRNA expressions of procollagen I and III, matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinease-1 (TIMP-1) were detected by in situ hybridization. The results showed that NaHS significantly increased plasma H2S, decreased mPAP and the percentage of MA and PMA of small pulmonary vessels in rats under hypoxia. Meanwhile, NaHS inhibited the proliferation of pulmonary artery smooth muscle cells (PASMCs) represented by a decrease in the expressions of PCNA and human U-II in pulmonary artery wall. NaHS reduced the expression of collagen I and III, elastin and TGF-beta(3) protein and decreased the expressions of procollagen I and III mRNA in pulmonary arteries of rats under hypoxia, but it did not impact the ratio of TIMP-1 mRNA to MMP-1 mRNA in pulmonary arteries of rats under hypoxia. These data suggested that H2S played an important role in the development of HPVSR. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000235564100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57021
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Chengde Med Sch, Chengde, Hebei Province, Peoples R China
2.Jishuitan Hosp, Dept Emergency, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Resp Med, Beijing 100034, Peoples R China
5.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China

Recommended Citation:
Jin, HF,Cong, BL,Zhao, B,et al. Effects of hydrogen sulfide on hypoxic pulmonary vascular structural remodeling[J]. LIFE SCIENCES,2006,78(12):1299-1309.
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