IR@PKUHSC  > 北京大学第一临床医学院  > 儿科
学科主题临床医学
Effects of hydrogen sulfide on hypoxic pulmonary vascular structural remodeling
Jin, HF; Cong, BL; Zhao, B; Zhang, CY; Liu, XM; Zhou, WJ; Shi, Y; Tang, CS; Du, JB
关键词Hydrogen Sulfide Hypoxia Pulmonary Vascular Structural Remodeling Proliferative Cell Nuclear Antigen Urotensin Ii Collagen Elastin Matrix Metalloproteinase-l Tissue Inhibitors Of Metalloproteinease-1
刊名LIFE SCIENCES
2006-02-16
DOI10.1016/j.lfs.2005.07.009
78期:12页:1299-1309
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]GROWTH-FACTOR-BETA ; NITRIC-OXIDE SYNTHASE ; HUMAN UROTENSIN-II ; CARBON-MONOXIDE ; HYPERTENSION ; RAT ; EXPRESSION ; HEART ; GENE ; INHIBITOR
英文摘要

study the role of hydrogen sulfide (H2S) in hypoxic pulmonary vascular structural remodeling (HPVSR), a total of 24 Wistar rats were randomly divided into three groups: control group (n=8), hypoxia group (n=8) and hypoxia with sodium hydrosulfide (hy+NaHS) group (n=8). The mean pulmonary artery pressure (mPAP), plasma H2S and the percentage of muscularized arteries (MA), partially muscularized arteries (PMA) and nonmuscularized arteries (NMA) in small pulmonary vessels were measured. Collagen I and 111, elastin, transforming growth factor-beta(3) (TGF-beta(3)), proliferative cell nuclear antigen (PCNA) and human urotensin II(U-II) expressions were detected by immunohistochemical assay. The mRNA expressions of procollagen I and III, matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinease-1 (TIMP-1) were detected by in situ hybridization. The results showed that NaHS significantly increased plasma H2S, decreased mPAP and the percentage of MA and PMA of small pulmonary vessels in rats under hypoxia. Meanwhile, NaHS inhibited the proliferation of pulmonary artery smooth muscle cells (PASMCs) represented by a decrease in the expressions of PCNA and human U-II in pulmonary artery wall. NaHS reduced the expression of collagen I and III, elastin and TGF-beta(3) protein and decreased the expressions of procollagen I and III mRNA in pulmonary arteries of rats under hypoxia, but it did not impact the ratio of TIMP-1 mRNA to MMP-1 mRNA in pulmonary arteries of rats under hypoxia. These data suggested that H2S played an important role in the development of HPVSR. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000235564100004
引用统计
被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57021
专题北京大学第一临床医学院_儿科
作者单位1.Chengde Med Sch, Chengde, Hebei Province, Peoples R China
2.Jishuitan Hosp, Dept Emergency, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
4.Peking Univ, Hosp 1, Dept Resp Med, Beijing 100034, Peoples R China
5.Peking Univ, Hosp 1, Inst Cardiovasc Res, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Jin, HF,Cong, BL,Zhao, B,et al. Effects of hydrogen sulfide on hypoxic pulmonary vascular structural remodeling[J]. LIFE SCIENCES,2006,78(12):1299-1309.
APA Jin, HF.,Cong, BL.,Zhao, B.,Zhang, CY.,Liu, XM.,...&Du, JB.(2006).Effects of hydrogen sulfide on hypoxic pulmonary vascular structural remodeling.LIFE SCIENCES,78(12),1299-1309.
MLA Jin, HF,et al."Effects of hydrogen sulfide on hypoxic pulmonary vascular structural remodeling".LIFE SCIENCES 78.12(2006):1299-1309.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jin, HF]的文章
[Cong, BL]的文章
[Zhao, B]的文章
百度学术
百度学术中相似的文章
[Jin, HF]的文章
[Cong, BL]的文章
[Zhao, B]的文章
必应学术
必应学术中相似的文章
[Jin, HF]的文章
[Cong, BL]的文章
[Zhao, B]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。