IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Expression of Survivin and Caspase 3 in Oral Squamous Cell Carcinoma and Peritumoral Tissue
Li, S. X.1,2; Chai, L.2,4; Cai, Z. G.3; Jin, L. J.2; Chen, Y.3; Wu, H. R.1; Sun, Z.1
关键词Survivin Caspase 3 Oral Squamous Cell Carcinoma Apoptosis
刊名ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
2012
DOI10.7314/APJCP.2012.13.10.5027
13期:10页:5027-5031
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]CANCER CELLS ; BREAST-CANCER ; APOPTOSIS ; DEATH ; GLIOBLASTOMA ; CHEMOTHERAPY ; PREDICTS ; NESTIN ; GENES ; DRUGS
英文摘要

This study was conducted to investigate the expression of survivin and caspase 3 in oral squamous cell carcinoma and peritumoral tissue, and possible pathogenesis mechanisms. We used ELISA and western blotting to detect the protein expression levels of survivin and caspase 3 in tissue. In situ hybridization and real-time PCR were applied to assess mRNA expression levels. In this study, 13 tumor samples and 13 peritumoral tissue samples were collected from oral squamous cell carcinoma patients and 10 normal tissue samples obtained from patients without tumor. The result showed that the protein and mRNA expression of survivin in carcinoma was the highest among three types of tissue; following was that in peritumoral tissue. No difference in caspase 3 zymogen between peritumoral tissue and normal tissue could be found, while it was evidently decreased in carcinoma tissue. Activated caspase 3 was detected in normal tissue but could not be identified in peritumoral or carcinoma tissue. Our results indicate that the expression of survivin is apparently elevated in tumoral and peritumoral tissue. Expression of activated caspase 3 was not detected in tumoral tissue and the expression of caspase 3 zymogen was decreased in tumoral tissue. Our findings suggest that survivin may inhibit both synthesis and activation of caspase 3, hence inhibiting cell apoptosis and facililitating eventual development of oral squamous cell carcinoma.

语种英语
WOS记录号WOS:000315302600036
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57022
专题北京大学口腔医学院
北京大学第二临床医学院_眼科
作者单位1.Univ Queensland, Sch Dent, Brisbane, Qld 4072, Australia
2.Capital Med Univ, Sch Stomatol, Beijing, Peoples R China
3.Peking Univ, Sch Stomatol, Beijing, Peoples R China
4.Univ Hong Kong, Fac Dent, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Li, S. X.,Chai, L.,Cai, Z. G.,et al. Expression of Survivin and Caspase 3 in Oral Squamous Cell Carcinoma and Peritumoral Tissue[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2012,13(10):5027-5031.
APA Li, S. X..,Chai, L..,Cai, Z. G..,Jin, L. J..,Chen, Y..,...&Sun, Z..(2012).Expression of Survivin and Caspase 3 in Oral Squamous Cell Carcinoma and Peritumoral Tissue.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,13(10),5027-5031.
MLA Li, S. X.,et al."Expression of Survivin and Caspase 3 in Oral Squamous Cell Carcinoma and Peritumoral Tissue".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 13.10(2012):5027-5031.
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