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学科主题临床医学
Echinacoside rescues the SHSY5Y neuronal cells from TNF alpha-induced apoptosis
Deng, M; Zhao, JY; Tu, PF; Jiang, Y; Li, ZB; Wang, YH
关键词Echinacoside Apoptosis Tnf Alpha Mitochondrial Membrane Potential Reactive Oxygen Species Caspase-3
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2004-11-28
DOI10.1016/j.ejphar.2004.09.059
505期:1-3页:11-18
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TUMOR-NECROSIS-FACTOR ; OXIDATIVE STRESS ; MITOCHONDRIA ; DEATH ; BCL-2 ; PHENYLETHANOIDS ; ANTIOXIDANT ; EXPRESSION ; DISEASE ; INJURY
英文摘要

We investigated the neuroprotective effect of echinacoside, one of the phenylethanoids isolated from the stems of Cistanches salsa, a Chinese herbal medicine, on tumor necrosis factor-alpha (TNFalpha)-induced apoptosis in human neuroblastoma (SHSY5Y) cells. Treatment of cultured SHSY5Y cells with TNFa 100 ng ml(-1) for 36 h stimulated apoptosis, as demonstrated by typical morphological changes, cell viability, DNA laddering, annexin-V binding, intracellular reactive oxygen species, mitochondrial membrane potential and caspase-3 activity. However, simultaneous treatment with echinacoside (1, 10 or 100 mug ml(-1)) attenuated the TNFalpha-mediated apoptosis. The antiapoptotic action of echinacoside was partially dependent on antioxidative stress effects, maintenance of mitochondria function, inhibition of caspase-3 activity and was also associated with increasing the expression of the antiapoptotic protein Bcl2. Thus, echinacoside has the neuroprotective capacity to antagonize TNFalpha-induced apoptosis in SHSY5Y cells and may be useful in treating some neurodegenerative diseases. (C) 2004 Elsevier B.V All rights reserved.

语种英语
WOS记录号WOS:000225419000002
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被引频次:49[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57026
专题北京大学第三临床医学院_职业病科
作者单位1.Peking Univ, Hosp 3, Res Ctr Occupat Med, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Neurol, Beijing 100083, Peoples R China
3.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China
4.Peking Union Med Coll, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
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GB/T 7714
Deng, M,Zhao, JY,Tu, PF,et al. Echinacoside rescues the SHSY5Y neuronal cells from TNF alpha-induced apoptosis[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2004,505(1-3):11-18.
APA Deng, M,Zhao, JY,Tu, PF,Jiang, Y,Li, ZB,&Wang, YH.(2004).Echinacoside rescues the SHSY5Y neuronal cells from TNF alpha-induced apoptosis.EUROPEAN JOURNAL OF PHARMACOLOGY,505(1-3),11-18.
MLA Deng, M,et al."Echinacoside rescues the SHSY5Y neuronal cells from TNF alpha-induced apoptosis".EUROPEAN JOURNAL OF PHARMACOLOGY 505.1-3(2004):11-18.
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