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学科主题: 临床医学
题名:
Echinacoside rescues the SHSY5Y neuronal cells from TNF alpha-induced apoptosis
作者: Deng, M; Zhao, JY; Tu, PF; Jiang, Y; Li, ZB; Wang, YH
关键词: echinacoside ; apoptosis ; TNF alpha ; mitochondrial membrane potential ; reactive oxygen species ; caspase-3
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2004-11-28
DOI: 10.1016/j.ejphar.2004.09.059
卷: 505, 期:1-3, 页:11-18
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TUMOR-NECROSIS-FACTOR ; OXIDATIVE STRESS ; MITOCHONDRIA ; DEATH ; BCL-2 ; PHENYLETHANOIDS ; ANTIOXIDANT ; EXPRESSION ; DISEASE ; INJURY
英文摘要:

We investigated the neuroprotective effect of echinacoside, one of the phenylethanoids isolated from the stems of Cistanches salsa, a Chinese herbal medicine, on tumor necrosis factor-alpha (TNFalpha)-induced apoptosis in human neuroblastoma (SHSY5Y) cells. Treatment of cultured SHSY5Y cells with TNFa 100 ng ml(-1) for 36 h stimulated apoptosis, as demonstrated by typical morphological changes, cell viability, DNA laddering, annexin-V binding, intracellular reactive oxygen species, mitochondrial membrane potential and caspase-3 activity. However, simultaneous treatment with echinacoside (1, 10 or 100 mug ml(-1)) attenuated the TNFalpha-mediated apoptosis. The antiapoptotic action of echinacoside was partially dependent on antioxidative stress effects, maintenance of mitochondria function, inhibition of caspase-3 activity and was also associated with increasing the expression of the antiapoptotic protein Bcl2. Thus, echinacoside has the neuroprotective capacity to antagonize TNFalpha-induced apoptosis in SHSY5Y cells and may be useful in treating some neurodegenerative diseases. (C) 2004 Elsevier B.V All rights reserved.

语种: 英语
WOS记录号: WOS:000225419000002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57026
Appears in Collections:北京大学第三临床医学院_职业病科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Res Ctr Occupat Med, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Dept Neurol, Beijing 100083, Peoples R China
3.Peking Univ, Modern Res Ctr Tradit Chinese Med, Beijing 100083, Peoples R China
4.Peking Union Med Coll, Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

Recommended Citation:
Deng, M,Zhao, JY,Tu, PF,et al. Echinacoside rescues the SHSY5Y neuronal cells from TNF alpha-induced apoptosis[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2004,505(1-3):11-18.
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