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学科主题: 临床医学
题名:
Molecular Markers of Early-Stage Mycosis Fungoides
作者: Zhang, Yaohua1,2,3; Wang, Yang1,2,4; Yu, Richard1,2; Huang, Yuanshen1,2; Su, Mingwan1,2; Xiao, Cheng1,2; Martinka, Magdalena5; Dutz, Jan P.6; Zhang, Xuejun7; Zheng, Zhizhong3; Zhou, Youwen1,2,6,7
刊名: JOURNAL OF INVESTIGATIVE DERMATOLOGY
发表日期: 2012-06-01
DOI: 10.1038/jid.2012.13
卷: 132, 期:6, 页:1698-1706
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dermatology
研究领域[WOS]: Dermatology
关键词[WOS]: T-CELL LYMPHOMA ; LARGE GENE LISTS ; SEZARY-SYNDROME ; INTERNATIONAL-SOCIETY ; CUTANEOUS-LYMPHOMAS ; METASTATIC MELANOMA ; ABERRANT EXPRESSION ; PROGRESSION ; SURVIVAL ; PROTEINS
英文摘要:

The lack of a specific marker differentiating early mycosis fungoides (eMF) from benign inflammatory dermatitis presents significant difficulties in the assessment and management of suspected MF patients, which often leads to delayed diagnosis and improper medical approaches. To address this, an investigation was carried out to characterize positive identification markers for eMF by comparing eMF lesions with healthy skin and benign inflammatory dermatitis, using high-throughput genomic transcription profiling. A total of 349 genes were differentially expressed in eMF lesions compared with normal skin. These genes belong to pathways associated with inflammation, immune activation, and apoptosis regulation. Most of them (N = 330) also demonstrated significant upregulation in chronic dermatitis, making them nonideal markers for eMF. Among them, 19 genes with specific enrichment in eMF lesions were identified that showed no significant upregulation in chronic dermatitis. Two of them, TOX and PDCD1, showed high discrimination power between eMF lesions and biopsies from benign dermatitis by RNA expression. Furthermore, TOX demonstrated highly specific staining of MF cells in eMF skin biopsies in immunohistochemistry and immunofluorescence, including the early epidermotropic cells in Pautrier′s microabscesses. This study demonstrates the potential of eMF-enriched genes, especially TOX, as molecular markers for histological diagnosis of eMF, which currently is a major diagnostic challenge.

语种: 英语
项目资助者: Canadian Dermatology Foundation ; Canadian Chinese Help Care Society ; Canadian Institutes of Health Research ; China Scholarship Council ; In-It-For-Life Foundation
WOS记录号: WOS:000304035000023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57028
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Univ British Columbia, Dept Dermatol & Skin Sci, Mol Med Lab, Vancouver, BC V5Z 4E8, Canada
2.British Columbia Canc Agcy, Skin Tumor Grp, Vancouver, BC V5Z 4E6, Canada
3.Anhui Med Univ, Inst Dermatol, Hefei, Anhui, Peoples R China
4.Univ British Columbia, Dept Dermatol & Skin Sci, Chieng Genom Ctr, Vancouver, BC V5Z 4E8, Canada
5.Fudan Univ, Dept Dermatol, Huashan Hosp, Shanghai 200433, Peoples R China
6.Peking Univ, Hosp 1, Dept Dermatol & Venerol, Beijing 100871, Peoples R China
7.Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC V5Z 4E8, Canada

Recommended Citation:
Zhang, Yaohua,Wang, Yang,Yu, Richard,et al. Molecular Markers of Early-Stage Mycosis Fungoides[J]. JOURNAL OF INVESTIGATIVE DERMATOLOGY,2012,132(6):1698-1706.
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