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学科主题: 临床医学
题名:
Investigation of diagnosis and treatment of hemolysis-elevated liver enzymes-low platelet counts (HELLP) syndrome: clinical analysis of 59 cases
作者: Wang Yong-qing; Wang Jing; Ye Rong-hua; Zhao Yang-yu
关键词: HELLP syndrome ; severe preeclampsia ; diagnosis ; treatment
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2010-05-20
DOI: 10.3760/cma.j.issn.0366-6999.2010.10.009
卷: 123, 期:10, 页:1273-1277
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: MATERNAL MORBIDITY ; MANAGEMENT ; PREGNANCY ; CONTROVERSIES ; DISORDERS
英文摘要:

Background Hemolysis-elevated liver enzymes-low platelet counts (HELLP) syndrome is a clinical condition occurring in middle and late stage pregnancy. It is characterized by hemolysis, elevated liver enzymes and low platelet counts. This study involves the analysis of the diagnosis, clinical characteristics and treatment of 59 cases of HELLP syndrome as well as the clinical classification, method of delivery and gestational age at delivery.

Methods Clinical data from 59 cases of HELLP syndrome occurring from January 2000 to December 2009 were analyzed retrospectively. Thirty-five cases were classified as complete HELLP syndrome and 24 cases were considered partial HELLP syndrome. Results Twenty-six of the 59 analyzed patients (44%) with complete HELLP syndrome showed rapid onset, severe signs, symptoms, and complications in addition to a poor clinical outcome. Complications included multiple organ dysfunction syndrome (MODS) occurring in 18 cases, eclampsia (3 cases), placental abruption (3 cases), and perinatal death (4 cases). The remaining 33 cases (24 with partial and 9 with complete HELLP) were characterized by less severe signs, symptoms, complications and progression of the condition. Two of these cases were complicated with MODS (6.1%), and 1 with perinatal death (3.0%). Twelve non-radical-type cases received conservative treatment. The remaining 4 patients had recurring HELLP syndrome (6.78%).

Conclusions HELLP syndrome is classified as the radical type and non-radical-type according to clinical characteristics and outcome. Classification of HELLP syndrome cases according to clinical features can help in the monitoring and treatment of the disease. Active termination of pregnancy should be considered for radical-type cases. Non-radical-type cases can undergo conservative treatment with close monitoring in an attempt to improve perinatal outcome without increasing maternal morbidity. Chin Med J2010;123(10):1273-1277

语种: 英语
WOS记录号: WOS:000278219900009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57030
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing 100191, Peoples R China

Recommended Citation:
Wang Yong-qing,Wang Jing,Ye Rong-hua,et al. Investigation of diagnosis and treatment of hemolysis-elevated liver enzymes-low platelet counts (HELLP) syndrome: clinical analysis of 59 cases[J]. CHINESE MEDICAL JOURNAL,2010,123(10):1273-1277.
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