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学科主题临床医学
Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen
Liu, Caiyun1,2; Dong, Bin3; Lu, Aiping3; Qu, Like1,2; Xing, Xiaofang1,2; Meng, Lin1,2; Wu, Jian1,2; Shi, Y. Eric4; Shou, Chengchao1,2
刊名BMC CANCER
2010-07-07
DOI10.1186/1471-2407-10-359
10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]MARKERS EGTM GUIDELINES ; COLORECTAL-CANCER ; BREAST-CANCER ; ALPHA-SYNUCLEIN ; TUMOR-MARKERS ; EUROPEAN GROUP ; GENE ; EXPRESSION ; CELLS ; LOCALIZATION
英文摘要

Background: Synuclein gamma (SNCG), initially identified as a breast cancer specific gene, is aberrantly expressed in many different malignant tumors but rarely expressed in matched nonneoplastic adjacent tissues. In this study, we investigated the prognostic potential of SNCG in colon cancer particularly in the patients with normal carcinoembryonic antigen (CEA) levels.

Methods: SNCG levels were assessed immunohistochemically in cancer tissues from 229 colon adenocarcinoma patients with a mean follow-up of 44 months. Correlations between SNCG levels and clinicopathologic features, preoperative serum CEA level, and clinical outcome were analyzed statistically using SPSS.

Results: SNCG levels in colon adenocarcinoma were closely associated with intravascular embolus and tumor recurrence but independent of preoperative serum CEA levels. SNCG expression was an independent prognostic factor of a shorter disease-free survival (DFS) and overall survival (OS) (P < 0.0001). Multivariate analysis revealed that both tissue SNCG and serum CEA were independent prognostic factors of DFS (P = 0.001, < 0.0001, respectively) for 170 patients with colon adenocarcinomas. Importantly, SNCG remained a prognostic determinant of DFS and OS (P = 0.001, 0.002) for 97 patients with normal preoperative serum CEA level.

Conclusions: Our results suggest for the first time that SNCG is a new independent predicator for poor prognosis in patients with colon adenocarcinoma, including those with normal CEA levels. Combination of CEA with SNCG improves prognostic evaluation for patients with colon adenocarcinoma.

语种英语
WOS记录号WOS:000282665400001
引用统计
被引频次:22[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57032
专题北京大学临床肿瘤学院
北京大学第三临床医学院_检验科
北京大学临床肿瘤学院_病理科
北京大学临床肿瘤学院_生化与分子生物学研究室
北京大学临床肿瘤学院_中心实验室
北京大学临床肿瘤学院_标本库
作者单位1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Sch Oncol, Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Dept Biochem & Mol Biol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
3.Peking Univ, Dept Pathol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
4.Long Isl Jewish Med Ctr, Dept Radiat Med, Feinstein Inst Med Res, New Hyde Pk, NY 11040 USA
推荐引用方式
GB/T 7714
Liu, Caiyun,Dong, Bin,Lu, Aiping,et al. Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen[J]. BMC CANCER,2010,10.
APA Liu, Caiyun.,Dong, Bin.,Lu, Aiping.,Qu, Like.,Xing, Xiaofang.,...&Shou, Chengchao.(2010).Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen.BMC CANCER,10.
MLA Liu, Caiyun,et al."Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen".BMC CANCER 10(2010).
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