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学科主题: 临床医学
题名:
Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen
作者: Liu, Caiyun1,2; Dong, Bin3; Lu, Aiping3; Qu, Like1,2; Xing, Xiaofang1,2; Meng, Lin1,2; Wu, Jian1,2; Shi, Y. Eric4; Shou, Chengchao1,2
刊名: BMC CANCER
发表日期: 2010-07-07
DOI: 10.1186/1471-2407-10-359
卷: 10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: MARKERS EGTM GUIDELINES ; COLORECTAL-CANCER ; BREAST-CANCER ; ALPHA-SYNUCLEIN ; TUMOR-MARKERS ; EUROPEAN GROUP ; GENE ; EXPRESSION ; CELLS ; LOCALIZATION
英文摘要:

Background: Synuclein gamma (SNCG), initially identified as a breast cancer specific gene, is aberrantly expressed in many different malignant tumors but rarely expressed in matched nonneoplastic adjacent tissues. In this study, we investigated the prognostic potential of SNCG in colon cancer particularly in the patients with normal carcinoembryonic antigen (CEA) levels.

Methods: SNCG levels were assessed immunohistochemically in cancer tissues from 229 colon adenocarcinoma patients with a mean follow-up of 44 months. Correlations between SNCG levels and clinicopathologic features, preoperative serum CEA level, and clinical outcome were analyzed statistically using SPSS.

Results: SNCG levels in colon adenocarcinoma were closely associated with intravascular embolus and tumor recurrence but independent of preoperative serum CEA levels. SNCG expression was an independent prognostic factor of a shorter disease-free survival (DFS) and overall survival (OS) (P < 0.0001). Multivariate analysis revealed that both tissue SNCG and serum CEA were independent prognostic factors of DFS (P = 0.001, < 0.0001, respectively) for 170 patients with colon adenocarcinomas. Importantly, SNCG remained a prognostic determinant of DFS and OS (P = 0.001, 0.002) for 97 patients with normal preoperative serum CEA level.

Conclusions: Our results suggest for the first time that SNCG is a new independent predicator for poor prognosis in patients with colon adenocarcinoma, including those with normal CEA levels. Combination of CEA with SNCG improves prognostic evaluation for patients with colon adenocarcinoma.

语种: 英语
所属项目编号: 2009CB521805 ; 2006AA02A249
项目资助者: National 973 Program ; National 863 Program
WOS记录号: WOS:000282665400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57032
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Sch Oncol, Minist Educ, Beijing 100142, Peoples R China
2.Peking Univ, Dept Biochem & Mol Biol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
3.Peking Univ, Dept Pathol, Sch Oncol, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
4.Long Isl Jewish Med Ctr, Dept Radiat Med, Feinstein Inst Med Res, New Hyde Pk, NY 11040 USA

Recommended Citation:
Liu, Caiyun,Dong, Bin,Lu, Aiping,et al. Synuclein gamma predicts poor clinical outcome in colon cancer with normal levels of carcinoembryonic antigen[J]. BMC CANCER,2010,10.
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