北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
A Highly alpha-Stereoselective Synthesis of Oligosaccharide Fragments of the Vi Antigen from Salmonella typhi and Their Antigenic Activities
作者: Yang, Lin1; Zhu, Jingjing1,2; Zheng, Xiu-Jing1; Tai, Guihua2; Ye, Xin-Shan1
关键词: antigens ; glycosylation ; oxazolidinones ; salmonella typhi ; stereoselectivity ; Vi antigens
刊名: CHEMISTRY-A EUROPEAN JOURNAL
发表日期: 2011-12-01
DOI: 10.1002/chem.201102615
卷: 17, 期:51, 页:14518-14526
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: CAPSULAR POLYSACCHARIDE VACCINE ; PRE-ACTIVATION PROTOCOL ; DEHYDRATIVE GLYCOSYLATION ; FEVER ; GLUCOSAMINE ; DERIVATIVES ; CHILDREN ; THIOGLYCOSIDES ; PHAGOCYTOSIS ; REACTIVITY
英文摘要:

In this paper, a convenient approach to the synthesis of the repeating alpha-(1 -> 4)-linked N-acetyl galactosaminuronic acid units from the capsular polysaccharide of Salmonella typhi is reported. The exclusively alpha-stereoselective glycosylation reactions were achieved by using oxazolidinone-protected glycosides as building blocks based on a pre-activation protocol. Di-, tri-, and tetrasaccharides were prepared by this short and efficient approach in high yields. The enzyme-linked immunosorbent assay experiments show that our synthetic tri- and tetrasaccharide had much higher antigenic activities than previously reported ones in the inhibition of antibody binding by the native polysaccharide. The results demonstrate that the antigenic activities of saccharides can be strengthened greatly by increasing the number of acetyl groups present.

语种: 英语
所属项目编号: 20732001
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000298542300023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57036
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat A0nd Biomimet Drugs, Beijing 100191, Peoples R China
2.NE Normal Univ, Sch Life Sci, Changchun 130024, Peoples R China

Recommended Citation:
Yang, Lin,Zhu, Jingjing,Zheng, Xiu-Jing,et al. A Highly alpha-Stereoselective Synthesis of Oligosaccharide Fragments of the Vi Antigen from Salmonella typhi and Their Antigenic Activities[J]. CHEMISTRY-A EUROPEAN JOURNAL,2011,17(51):14518-14526.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Lin]'s Articles
[Zhu, Jingjing]'s Articles
[Zheng, Xiu-Jing]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Lin]‘s Articles
[Zhu, Jingjing]‘s Articles
[Zheng, Xiu-Jing]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace