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Effect of theophylline on endogenous hydrogen sulfide production in patients with COPD
Chen, Ya-Hong1; Yao, Wan-Zhen1; Ding, Yan-Ling1; Geng, Bin2; Lu, Ming1; Tang, Chao-Shu2
关键词Airway Inflammation Chronic Obstructive Pulmonary Disease Hydrogen Sulfide Nitric Oxide Theophylline
刊名PULMONARY PHARMACOLOGY & THERAPEUTICS
2008
DOI10.1016/j.pupt.2006.11.002
21期:1页:40-46
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Respiratory System
研究领域[WOS]Pharmacology & Pharmacy ; Respiratory System
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; EXHALED NITRIC-OXIDE ; INFLAMMATION ; INJURY ; ASTHMA ; BRAIN ; H2S
英文摘要

Background: Airway inflammation plays a role in the pathogenesis of chronic obstructive pulmonary disease (COPD). Endogenous hydrogen sulfide (H(2)S) is involved in the physiological and pathophysiological process in systemic inflammation and may be involved in the pathogenesis of airway inflammation and airflow obstruction in COPD. The non-selective phosphodiesterase inhibitor theophylline has bronchodilator/anti-inflammatory properties and is widely used in the treatment of airways diseases. It is not fully understood whether endogenous H(2)S mediates the mechanism of theophylline anti-inflammatory effect.

Methods: The effect of short-term theophylline treatment on airway inflammation and endogenous H,S production was prospectively studied in thirty-seven patients with stable COPD. Patients were randomly divided into theophylline-treatment group (nineteen patients, orally given sustained theophylline tablets for 1 month, 0.2g, q12h.) and control group (eighteen patients, not given ally theophylline). Symptom score, lung function, total and differential cell counts in sputum, serum H(2)S and nitric oxide (NO(x)) levels, sputum and serum IL-8 levels were measured at baseline and I month later.

Results: No significant difference was found in symptom scores, lung function and other investigated experimental parameters at baseline between treatment and control groups, and between baseline and a month follow-up in control patients. Symptom scores were significantly lowered only in the treated patients after treatment, compared with those before (P<0.01). The proportion of neutrophils in Sputum was significantly decreased (P<0.05) while that of macrophages was markedly increased (P<0.01) in the treated patients after treatment, compared with that before. No significant change was found in serum H(2)S and NO(x) levels, serum and sputum IL-8 levels before and after experiment in treatment group. Serum H(2)S level correlated positively with percentage of predicted FEV(1) (r = 0.465, P = 0.005), and with proportion of sputum macrophages (r = 0.349, P = 0.05), but negatively with proportion of sputum neutrophils (r = -0.351, P = 0.049) in all patients at baseline.

Conclusions: Short-term theophylline treatment improved symptoms and decreased sputum neutrophils in COPD, while serum H(2)S levels were not affected in Our Study population. Large samples will be needed to illustrate the effect of long-term theophylline treatment on inflammatory mediators and H(2)S generation in COPD. (C) 2006 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000262943300007
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57048
专题北京大学第三临床医学院_呼吸科
北京大学基础医学院
北京大学第三临床医学院_运动医学研究所
作者单位1.Peking Univ, Hosp 3, Resp Dept, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, Ya-Hong,Yao, Wan-Zhen,Ding, Yan-Ling,et al. Effect of theophylline on endogenous hydrogen sulfide production in patients with COPD[J]. PULMONARY PHARMACOLOGY &amp; THERAPEUTICS,2008,21(1):40-46.
APA Chen, Ya-Hong,Yao, Wan-Zhen,Ding, Yan-Ling,Geng, Bin,Lu, Ming,&Tang, Chao-Shu.(2008).Effect of theophylline on endogenous hydrogen sulfide production in patients with COPD.PULMONARY PHARMACOLOGY & THERAPEUTICS,21(1),40-46.
MLA Chen, Ya-Hong,et al."Effect of theophylline on endogenous hydrogen sulfide production in patients with COPD".PULMONARY PHARMACOLOGY & THERAPEUTICS 21.1(2008):40-46.
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