北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 期刊论文
学科主题: 临床医学
题名:
A Novel Bispecific Antibody, S-Fab, Induces Potent Cancer Cell Killing
作者: Li, Li1,2; He, Ping1,2; Zhou, Changhua1,2; Jing, Li1,2; Dong, Bin1,2; Chen, Siqi1,2; Zhang, Ning3; Liu, Yawei4; Miao, Ji1,2; Wang, Zhong1,2; Li, Qing1,2
关键词: bispecific antibody ; single-domain antibody ; carcinoembryonic antigen ; CD3 ; bacterial expression
刊名: JOURNAL OF IMMUNOTHERAPY
发表日期: 2015-11-01
DOI: 10.1097/CJI.0000000000000099
卷: 38, 期:9, 页:350-356
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Immunology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Immunology ; Research & Experimental Medicine
关键词[WOS]: SINGLE-DOMAIN ANTIBODIES ; CARCINOEMBRYONIC ANTIGEN ; T-CELLS ; CYTOTOXICITY ; LYMPHOCYTES ; ACTIVATION ; EXPRESSION ; CONSTRUCT ; REGION ; TUMORS
英文摘要:

Bispecific antibodies that engage immune cells to kill cancer cells have been actively studied in cancer immunotherapy. In this study, we present a novel bispecific format, S-Fab, fabricated by linking a single-domain anti-carcinoembryonic antigen VHH to a conventional anti-CD3 Fab. In contrast to most bispecific antibodies, the S-Fab bispecific antibody can be efficiently expressed and purified from bacteria. The purified S-Fab is stable in serum and is able to recruit T cells to drive potent cancer cell killing. In xenograft models, the S-Fab antibody suppresses tumor growth in the presence of human immune cells. Our study suggested that the bispecific S-Fab format can be applied to a wide range of immunotherapies.

语种: 英语
所属项目编号: 2011Y038
项目资助者: Introduced Innovative R&amp ; D Team Leadership of Guangdong Province (PR China)
WOS记录号: WOS:000363375600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57049
Appears in Collections:北京大学临床肿瘤学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Hlth Div Guard Bur, Gen Staff Dept PLA, Beijing, Peoples R China
2.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Ctr Cellular & Struct Biol, Guangzhou 510006, Guangdong, Peoples R China
4.Peking Univ, Canc Hosp, Beijing Inst Canc Res, Beijing 100871, Peoples R China

Recommended Citation:
Li, Li,He, Ping,Zhou, Changhua,et al. A Novel Bispecific Antibody, S-Fab, Induces Potent Cancer Cell Killing[J]. JOURNAL OF IMMUNOTHERAPY,2015,38(9):350-356.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Li]'s Articles
[He, Ping]'s Articles
[Zhou, Changhua]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Li]‘s Articles
[He, Ping]‘s Articles
[Zhou, Changhua]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace