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学科主题: 临床医学
题名:
A Novel Bispecific Antibody, S-Fab, Induces Potent Cancer Cell Killing
作者: Li, Li1,2; He, Ping1,2; Zhou, Changhua1,2; Jing, Li1,2; Dong, Bin1,2; Chen, Siqi1,2; Zhang, Ning3; Liu, Yawei4; Miao, Ji1,2; Wang, Zhong1,2; Li, Qing1,2
关键词: bispecific antibody ; single-domain antibody ; carcinoembryonic antigen ; CD3 ; bacterial expression
刊名: JOURNAL OF IMMUNOTHERAPY
发表日期: 2015-11-01
DOI: 10.1097/CJI.0000000000000099
卷: 38, 期:9, 页:350-356
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Immunology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Immunology ; Research & Experimental Medicine
关键词[WOS]: SINGLE-DOMAIN ANTIBODIES ; CARCINOEMBRYONIC ANTIGEN ; T-CELLS ; CYTOTOXICITY ; LYMPHOCYTES ; ACTIVATION ; EXPRESSION ; CONSTRUCT ; REGION ; TUMORS
英文摘要:

Bispecific antibodies that engage immune cells to kill cancer cells have been actively studied in cancer immunotherapy. In this study, we present a novel bispecific format, S-Fab, fabricated by linking a single-domain anti-carcinoembryonic antigen VHH to a conventional anti-CD3 Fab. In contrast to most bispecific antibodies, the S-Fab bispecific antibody can be efficiently expressed and purified from bacteria. The purified S-Fab is stable in serum and is able to recruit T cells to drive potent cancer cell killing. In xenograft models, the S-Fab antibody suppresses tumor growth in the presence of human immune cells. Our study suggested that the bispecific S-Fab format can be applied to a wide range of immunotherapies.

语种: 英语
所属项目编号: 2011Y038
项目资助者: Introduced Innovative R&amp ; D Team Leadership of Guangdong Province (PR China)
WOS记录号: WOS:000363375600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57049
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Hlth Div Guard Bur, Gen Staff Dept PLA, Beijing, Peoples R China
2.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Ctr Cellular & Struct Biol, Guangzhou 510006, Guangdong, Peoples R China
4.Peking Univ, Canc Hosp, Beijing Inst Canc Res, Beijing 100871, Peoples R China

Recommended Citation:
Li, Li,He, Ping,Zhou, Changhua,et al. A Novel Bispecific Antibody, S-Fab, Induces Potent Cancer Cell Killing[J]. JOURNAL OF IMMUNOTHERAPY,2015,38(9):350-356.
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