IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
A Novel Bispecific Antibody, S-Fab, Induces Potent Cancer Cell Killing
Li, Li1,2; He, Ping1,2; Zhou, Changhua1,2; Jing, Li1,2; Dong, Bin1,2; Chen, Siqi1,2; Zhang, Ning3; Liu, Yawei4; Miao, Ji1,2; Wang, Zhong1,2; Li, Qing1,2
关键词Bispecific Antibody Single-domain Antibody Carcinoembryonic Antigen Cd3 Bacterial Expression
刊名JOURNAL OF IMMUNOTHERAPY
2015-11-01
DOI10.1097/CJI.0000000000000099
38期:9页:350-356
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Immunology ; Medicine, Research & Experimental
研究领域[WOS]Oncology ; Immunology ; Research & Experimental Medicine
关键词[WOS]SINGLE-DOMAIN ANTIBODIES ; CARCINOEMBRYONIC ANTIGEN ; T-CELLS ; CYTOTOXICITY ; LYMPHOCYTES ; ACTIVATION ; EXPRESSION ; CONSTRUCT ; REGION ; TUMORS
英文摘要

Bispecific antibodies that engage immune cells to kill cancer cells have been actively studied in cancer immunotherapy. In this study, we present a novel bispecific format, S-Fab, fabricated by linking a single-domain anti-carcinoembryonic antigen VHH to a conventional anti-CD3 Fab. In contrast to most bispecific antibodies, the S-Fab bispecific antibody can be efficiently expressed and purified from bacteria. The purified S-Fab is stable in serum and is able to recruit T cells to drive potent cancer cell killing. In xenograft models, the S-Fab antibody suppresses tumor growth in the presence of human immune cells. Our study suggested that the bispecific S-Fab format can be applied to a wide range of immunotherapies.

语种英语
WOS记录号WOS:000363375600002
项目编号2011Y038
资助机构Introduced Innovative R&amp ; D Team Leadership of Guangdong Province (PR China)
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57049
专题北京大学临床肿瘤学院
作者单位1.Hlth Div Guard Bur, Gen Staff Dept PLA, Beijing, Peoples R China
2.Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China
3.Sun Yat Sen Univ, Ctr Cellular & Struct Biol, Guangzhou 510006, Guangdong, Peoples R China
4.Peking Univ, Canc Hosp, Beijing Inst Canc Res, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Li, Li,He, Ping,Zhou, Changhua,et al. A Novel Bispecific Antibody, S-Fab, Induces Potent Cancer Cell Killing[J]. JOURNAL OF IMMUNOTHERAPY,2015,38(9):350-356.
APA Li, Li.,He, Ping.,Zhou, Changhua.,Jing, Li.,Dong, Bin.,...&Li, Qing.(2015).A Novel Bispecific Antibody, S-Fab, Induces Potent Cancer Cell Killing.JOURNAL OF IMMUNOTHERAPY,38(9),350-356.
MLA Li, Li,et al."A Novel Bispecific Antibody, S-Fab, Induces Potent Cancer Cell Killing".JOURNAL OF IMMUNOTHERAPY 38.9(2015):350-356.
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