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学科主题: 临床医学
题名:
Analysis of human cytomegalovirus glycoprotein N genotypes in Chinese hematopoietic stem cell transplant recipients
作者: Xia, Chang-sheng; Zhang, Zheng
刊名: ARCHIVES OF VIROLOGY
发表日期: 2011
DOI: 10.1007/s00705-010-0811-0
卷: 156, 期:1, 页:17-23
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: GENOMIC VARIANTS ; GN GENOTYPES ; ENVELOPE GLYCOPROTEIN ; TO-CELL ; INFECTION ; STRAINS ; DISEASE ; COMPLEX ; GO ; EPIDEMIOLOGY
英文摘要:

Human cytomegalovirus (HCMV) genomic polymorphisms have been used to investigate correlations between virus variants and clinical characteristics. We explored the distribution of HCMV glycoprotein N (gN) genotypes and their roles relative to clinical features in a population of Chinese hematopoietic stem cell transplant (HSCT) recipients. This prospective analysis involved HCMV clinical isolates obtained from 102 HSCT patients. Real-time quantitative PCR and PCR-based restriction fragment length polymorphism analysis were applied for the determination of viral loads and gN genotypes. The distribution of HCMV gN genotypes was as follows: gN1, 6/102 (5.9%); gN2, 10/102 (9.8%); gN3a, 17/102 (16.7%); gN3b, 5/102 (4.9%); gN4a, 12/102 (11.7%); gN4b, 9/102 (8.8%); gN4d, 2/102 (2.0%); and mixtures, 41/102 (40.2%). No particular HCMV gN genotype was significantly associated with specific clinical characteristics. The HCMV gN3a genotype was the most prevalent among Chinese HSCT recipients, but HCMV gN genotypes may have no correlation with clinical features in HSCT patients.

语种: 英语
WOS记录号: WOS:000286362000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57050
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China

Recommended Citation:
Xia, Chang-sheng,Zhang, Zheng. Analysis of human cytomegalovirus glycoprotein N genotypes in Chinese hematopoietic stem cell transplant recipients[J]. ARCHIVES OF VIROLOGY,2011,156(1):17-23.
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