IR@PKUHSC  > 北京大学第二临床医学院
学科主题临床医学
Analysis of human cytomegalovirus glycoprotein N genotypes in Chinese hematopoietic stem cell transplant recipients
Xia, Chang-sheng; Zhang, Zheng
刊名ARCHIVES OF VIROLOGY
2011
DOI10.1007/s00705-010-0811-0
156期:1页:17-23
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]GENOMIC VARIANTS ; GN GENOTYPES ; ENVELOPE GLYCOPROTEIN ; TO-CELL ; INFECTION ; STRAINS ; DISEASE ; COMPLEX ; GO ; EPIDEMIOLOGY
英文摘要

Human cytomegalovirus (HCMV) genomic polymorphisms have been used to investigate correlations between virus variants and clinical characteristics. We explored the distribution of HCMV glycoprotein N (gN) genotypes and their roles relative to clinical features in a population of Chinese hematopoietic stem cell transplant (HSCT) recipients. This prospective analysis involved HCMV clinical isolates obtained from 102 HSCT patients. Real-time quantitative PCR and PCR-based restriction fragment length polymorphism analysis were applied for the determination of viral loads and gN genotypes. The distribution of HCMV gN genotypes was as follows: gN1, 6/102 (5.9%); gN2, 10/102 (9.8%); gN3a, 17/102 (16.7%); gN3b, 5/102 (4.9%); gN4a, 12/102 (11.7%); gN4b, 9/102 (8.8%); gN4d, 2/102 (2.0%); and mixtures, 41/102 (40.2%). No particular HCMV gN genotype was significantly associated with specific clinical characteristics. The HCMV gN3a genotype was the most prevalent among Chinese HSCT recipients, but HCMV gN genotypes may have no correlation with clinical features in HSCT patients.

语种英语
WOS记录号WOS:000286362000003
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57050
专题北京大学第二临床医学院
北京大学第一临床医学院_泌尿外科
作者单位Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China
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Xia, Chang-sheng,Zhang, Zheng. Analysis of human cytomegalovirus glycoprotein N genotypes in Chinese hematopoietic stem cell transplant recipients[J]. ARCHIVES OF VIROLOGY,2011,156(1):17-23.
APA Xia, Chang-sheng,&Zhang, Zheng.(2011).Analysis of human cytomegalovirus glycoprotein N genotypes in Chinese hematopoietic stem cell transplant recipients.ARCHIVES OF VIROLOGY,156(1),17-23.
MLA Xia, Chang-sheng,et al."Analysis of human cytomegalovirus glycoprotein N genotypes in Chinese hematopoietic stem cell transplant recipients".ARCHIVES OF VIROLOGY 156.1(2011):17-23.
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