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Food restriction alters villi morphology in obese rats: gut mechanism for weight regain?
Zhang, Jian Gang1,2; Sun, Xiao Wei2; Gao, Peng3; Xie, Lan1; Liu, Wen Qian1; Xiao, Hai Tao1; Ai, Hua1
关键词Food Restriction Villi Morphology Obesity Weight Loss Weight Regain Mechanisms
刊名EXPERIMENTAL BIOLOGY AND MEDICINE
2012-09-01
DOI10.1258/ebm.2012.012002
237期:9页:993-999
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]RANDOMIZED-CONTROLLED-TRIAL ; SMALL-INTESTINE ; ENERGY DIET ; SMALL-BOWEL ; MAINTENANCE ; GHRELIN ; ADULTS ; MUCOSA ; STRATEGIES ; RESPONSES
英文摘要

Weight regain after a long-term weight-loss program is a greater problem in obesity treatment than is weight reduction. Hence, the gut may elevate the absorption rate and nutrient transportation remarkably during chronic food restriction. The extension of gut absorption may be one possible reason for weight regain. But there is little information about the mechanisms that regulate intestinal absorption during food restriction. In this study, we show that the surface absorptive areas of gut villi may be enlarged in the jejunum of rats maintained on a food restriction regimen compared with animals submitted to swimming or sedentary behavior. Our findings show that simply reducing the amount of food intake results in an increased appetite accompanied with obvious weight regain, and suggest that the resulting enlargement of villi surface areas plays a key role in the regain of weight reduction. These results bolster accumulating evidence that gut absorption may be a substantial mechanism for resistance of weight loss and enhancing the weight regain process.

语种英语
WOS记录号WOS:000309852600002
项目编号30270636 ; 30671015 ; lzujbky - 2010-125
资助机构National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57052
专题北京大学第三临床医学院_运动医学研究所
作者单位1.Lanzhou Univ, Inst Pathol, Lanzhou 730000, Peoples R China
2.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100191, Peoples R China
3.Hebei Normal Univ, Coll Sports, Shijiazhuang 050000, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jian Gang,Sun, Xiao Wei,Gao, Peng,et al. Food restriction alters villi morphology in obese rats: gut mechanism for weight regain?[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2012,237(9):993-999.
APA Zhang, Jian Gang.,Sun, Xiao Wei.,Gao, Peng.,Xie, Lan.,Liu, Wen Qian.,...&Ai, Hua.(2012).Food restriction alters villi morphology in obese rats: gut mechanism for weight regain?.EXPERIMENTAL BIOLOGY AND MEDICINE,237(9),993-999.
MLA Zhang, Jian Gang,et al."Food restriction alters villi morphology in obese rats: gut mechanism for weight regain?".EXPERIMENTAL BIOLOGY AND MEDICINE 237.9(2012):993-999.
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