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学科主题: 临床医学
题名:
Food restriction alters villi morphology in obese rats: gut mechanism for weight regain?
作者: Zhang, Jian Gang1,2; Sun, Xiao Wei2; Gao, Peng3; Xie, Lan1; Liu, Wen Qian1; Xiao, Hai Tao1; Ai, Hua1
关键词: food restriction ; villi morphology ; obesity ; weight loss ; weight regain ; mechanisms
刊名: EXPERIMENTAL BIOLOGY AND MEDICINE
发表日期: 2012-09-01
DOI: 10.1258/ebm.2012.012002
卷: 237, 期:9, 页:993-999
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: RANDOMIZED-CONTROLLED-TRIAL ; SMALL-INTESTINE ; ENERGY DIET ; SMALL-BOWEL ; MAINTENANCE ; GHRELIN ; ADULTS ; MUCOSA ; STRATEGIES ; RESPONSES
英文摘要:

Weight regain after a long-term weight-loss program is a greater problem in obesity treatment than is weight reduction. Hence, the gut may elevate the absorption rate and nutrient transportation remarkably during chronic food restriction. The extension of gut absorption may be one possible reason for weight regain. But there is little information about the mechanisms that regulate intestinal absorption during food restriction. In this study, we show that the surface absorptive areas of gut villi may be enlarged in the jejunum of rats maintained on a food restriction regimen compared with animals submitted to swimming or sedentary behavior. Our findings show that simply reducing the amount of food intake results in an increased appetite accompanied with obvious weight regain, and suggest that the resulting enlargement of villi surface areas plays a key role in the regain of weight reduction. These results bolster accumulating evidence that gut absorption may be a substantial mechanism for resistance of weight loss and enhancing the weight regain process.

语种: 英语
所属项目编号: 30270636 ; 30671015 ; lzujbky - 2010-125
项目资助者: National Natural Science Foundation of China ; Fundamental Research Funds for the Central Universities
WOS记录号: WOS:000309852600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57052
Appears in Collections:北京大学第三临床医学院_运动医学研究所_期刊论文

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作者单位: 1.Lanzhou Univ, Inst Pathol, Lanzhou 730000, Peoples R China
2.Peking Univ, Hosp 3, Inst Sports Med, Beijing 100191, Peoples R China
3.Hebei Normal Univ, Coll Sports, Shijiazhuang 050000, Peoples R China

Recommended Citation:
Zhang, Jian Gang,Sun, Xiao Wei,Gao, Peng,et al. Food restriction alters villi morphology in obese rats: gut mechanism for weight regain?[J]. EXPERIMENTAL BIOLOGY AND MEDICINE,2012,237(9):993-999.
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