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学科主题: 临床医学
题名:
Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats
作者: Zhao, Ying; Zhai, Desheng; Chen, Xijing; Yang, Jinnan; Song, Xiangfeng; He, Hui; Yu, Qiaoling; Xing, Yan
关键词: hepatic injury ; carbon tetrachloride ; alpha-naphthylisothiocyanate ; glucuronidation ; bile excretion ; ketoprofen
刊名: TOXICOLOGY
发表日期: 2007-02-12
DOI: 10.1016/j.tox.2006.11.008
卷: 230, 期:2-3, 页:145-150
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Toxicology
关键词[WOS]: HUMAN LIVER ; GLYCYRRHIZIN ; DRUGS ; ACID
英文摘要:

A pharmacokinetic study was carried out in rats to investigate the effects of experimental hepatic injury on the liver glucuronidation and bile excretion of ketoprofen (KP) and its glucuronides (KPGs). In vivo, KP (20 mg/kg b.w.) was intravenously administered to carbon tetrachloride (CCl4) or alpha-naphthylisothiocyanate (ANIT) induced hepatic injury male rats. Concentrations of KP and its glucuronides (S-KPG and R-KPG) in plasma and bile were determined by RP-HPLC. It was observed that there was significant difference in the accumulative bile excretion of KPGs between the CCl4 intoxicated rats and the normal rats (54 +/- 18.3% versus 90 +/- 6.9%), while it was extremely inhibited in ANIT intoxicated rats (2.0 +/- 3.1 % versus 90 6.9%). As the result of reduction of KPGs excreted in bile, the area under the curve (AUC((0-infinity))) of KP and KPGs were higher in blood in CCl4 and ANIT hepatic injury rats than those of the normal rats. Specifically, ANIT caused approximately 10-fold elevation of AUC((0-infinity)) of plasma S-KPG. In microsomal incubations experiment, the glucuronyltransferase activity was impaired in CCl4 and ANIT intoxicated rats. It suggested that the glucuronyltransferase activity was impaired in CCl4 and ANIT intoxicated rats, while the bile excretion function was suppressed extremely in ANIT intoxicated rats. (c) 2006 Published by Elsevier Ireland Ltd.

语种: 英语
WOS记录号: WOS:000244376900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57057
Appears in Collections:北京大学第三临床医学院_儿科_期刊论文

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作者单位: 1.Xinxiang Med Univ, Xinxiang 463003, Henan, Peoples R China
2.China Pharmaceut Univ, Ctr Drug Metab & Pharmacokinet, Nanjing 210009, Peoples R China
3.Peking Univ, Hosp 3, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Zhao, Ying,Zhai, Desheng,Chen, Xijing,et al. Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats[J]. TOXICOLOGY,2007,230(2-3):145-150.
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