IR@PKUHSC  > 北京大学第三临床医学院  > 儿科
学科主题临床医学
Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats
Zhao, Ying; Zhai, Desheng; Chen, Xijing; Yang, Jinnan; Song, Xiangfeng; He, Hui; Yu, Qiaoling; Xing, Yan
关键词Hepatic Injury Carbon Tetrachloride Alpha-naphthylisothiocyanate Glucuronidation Bile Excretion Ketoprofen
刊名TOXICOLOGY
2007-02-12
DOI10.1016/j.tox.2006.11.008
230期:2-3页:145-150
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Toxicology
研究领域[WOS]Pharmacology & Pharmacy ; Toxicology
关键词[WOS]HUMAN LIVER ; GLYCYRRHIZIN ; DRUGS ; ACID
英文摘要

A pharmacokinetic study was carried out in rats to investigate the effects of experimental hepatic injury on the liver glucuronidation and bile excretion of ketoprofen (KP) and its glucuronides (KPGs). In vivo, KP (20 mg/kg b.w.) was intravenously administered to carbon tetrachloride (CCl4) or alpha-naphthylisothiocyanate (ANIT) induced hepatic injury male rats. Concentrations of KP and its glucuronides (S-KPG and R-KPG) in plasma and bile were determined by RP-HPLC. It was observed that there was significant difference in the accumulative bile excretion of KPGs between the CCl4 intoxicated rats and the normal rats (54 +/- 18.3% versus 90 +/- 6.9%), while it was extremely inhibited in ANIT intoxicated rats (2.0 +/- 3.1 % versus 90 6.9%). As the result of reduction of KPGs excreted in bile, the area under the curve (AUC((0-infinity))) of KP and KPGs were higher in blood in CCl4 and ANIT hepatic injury rats than those of the normal rats. Specifically, ANIT caused approximately 10-fold elevation of AUC((0-infinity)) of plasma S-KPG. In microsomal incubations experiment, the glucuronyltransferase activity was impaired in CCl4 and ANIT intoxicated rats. It suggested that the glucuronyltransferase activity was impaired in CCl4 and ANIT intoxicated rats, while the bile excretion function was suppressed extremely in ANIT intoxicated rats. (c) 2006 Published by Elsevier Ireland Ltd.

语种英语
WOS记录号WOS:000244376900005
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57057
专题北京大学第三临床医学院_儿科
作者单位1.Xinxiang Med Univ, Xinxiang 463003, Henan, Peoples R China
2.China Pharmaceut Univ, Ctr Drug Metab & Pharmacokinet, Nanjing 210009, Peoples R China
3.Peking Univ, Hosp 3, Dept Pediat, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhao, Ying,Zhai, Desheng,Chen, Xijing,et al. Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats[J]. TOXICOLOGY,2007,230(2-3):145-150.
APA Zhao, Ying.,Zhai, Desheng.,Chen, Xijing.,Yang, Jinnan.,Song, Xiangfeng.,...&Xing, Yan.(2007).Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats.TOXICOLOGY,230(2-3),145-150.
MLA Zhao, Ying,et al."Ketoprofen glucuronidation and bile excretion in carbon tetrachloride and alpha-naphthylisothiocyanate induced hepatic injury rats".TOXICOLOGY 230.2-3(2007):145-150.
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