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学科主题: 临床医学
题名:
Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction
作者: Yang, Shi-Wei1; Zhou, Yu-Jie1; Hu, Da-Yi2; Nie, Xiao-Min1; Liu, Yu-Yang1; Hua, Qi3; Wang, Xian4; Li, Hong-Wei5; BEAMIS Study Grp
刊名: HEART
发表日期: 2010-09-01
DOI: 10.1136/hrt.2009.189316
卷: 96, 期:18, 页:1444-1450
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ACUTE CORONARY SYNDROMES ; DIABETES-MELLITUS ; BLOOD-GLUCOSE ; ELDERLY-PATIENTS ; HYPERGLYCEMIA ; INSULIN ; OUTCOMES ; THERAPY ; ARTERY ; TRIAL
英文摘要:

Objective To assess the association between fasting plasma glucose (FPG) levels on admission and mortality in older patients with acute myocardial infarction (AMI), and compare the effects of FPG levels on outcomes in the context of contemporary treatments, including drug treatment, percutaneous coronary intervention and coronary artery bypass grafting.

Methods From April 2004 to October 2006, 1854 older (age >= 65 years) patients with AMI were enrolled in the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS) consecutively. Patients were categorised into 4 groups: hypoglycaemia group (N=443, 23.9%), FPG <= 5 mmol/l; euglycaemia group (N=812, 43.8%), FPG >= 5.1 to <= 7.0 mmol/l (5-7 mmol/l); mild hyperglycaemia group (N=308, 16.6%), FPG >= 7.1 to <= 9.0mmol/l (7-9 mmol/l); and severe hyperglycaemia group (N=291, 15.7%), FPG >= 9.1 mmol/l. The primary end point was in-hospital and 3-year all-cause mortality from the day of admission.

Results Compared with the euglycaemia group, hypoglycaemia or hyperglycaemia groups were all associated with higher in-hospital and 3-year all-cause mortality. There was a U-shaped relationship between admission FPG levels and short- and long-term all-cause mortality. This U-shaped relationship applied equally to subgroups in the context of contemporary treatments.

Conclusions In older patients with AMI, increased as well as decreased admission FPG levels could predict higher in-hospital and 3-year mortality. There was a striking U-shaped relationship between admission FPG levels and short-and long-term mortality. An initial admission FPG level >= 5.1 to <= 7.0 mmol/l may be desirable because it was associated with better clinical outcomes.

语种: 英语
所属项目编号: Z0005190042811
项目资助者: Beijing Municipal Science and Technology Commission
WOS记录号: WOS:000281666900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57059
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Gen Hosp Beijing Millitary, Dept Cardiol, Beijing, Peoples R China
2.Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Xuanwu Hosp, Dept Cardiol, Beijing 100029, Peoples R China
5.Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing 100029, Peoples R China

Recommended Citation:
Yang, Shi-Wei,Zhou, Yu-Jie,Hu, Da-Yi,et al. Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction[J]. HEART,2010,96(18):1444-1450.
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