IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction
Yang, Shi-Wei1; Zhou, Yu-Jie1; Hu, Da-Yi2; Nie, Xiao-Min1; Liu, Yu-Yang1; Hua, Qi3; Wang, Xian4; Li, Hong-Wei5; BEAMIS Study Grp
刊名HEART
2010-09-01
DOI10.1136/hrt.2009.189316
96期:18页:1444-1450
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者Beijing Municipal Science and Technology Commission ; Beijing Municipal Science and Technology Commission
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]ACUTE CORONARY SYNDROMES ; DIABETES-MELLITUS ; BLOOD-GLUCOSE ; ELDERLY-PATIENTS ; HYPERGLYCEMIA ; INSULIN ; OUTCOMES ; THERAPY ; ARTERY ; TRIAL
英文摘要

Objective To assess the association between fasting plasma glucose (FPG) levels on admission and mortality in older patients with acute myocardial infarction (AMI), and compare the effects of FPG levels on outcomes in the context of contemporary treatments, including drug treatment, percutaneous coronary intervention and coronary artery bypass grafting.

Methods From April 2004 to October 2006, 1854 older (age >= 65 years) patients with AMI were enrolled in the Beijing Elderly Acute Myocardial Infarction Study (BEAMIS) consecutively. Patients were categorised into 4 groups: hypoglycaemia group (N=443, 23.9%), FPG <= 5 mmol/l; euglycaemia group (N=812, 43.8%), FPG >= 5.1 to <= 7.0 mmol/l (5-7 mmol/l); mild hyperglycaemia group (N=308, 16.6%), FPG >= 7.1 to <= 9.0mmol/l (7-9 mmol/l); and severe hyperglycaemia group (N=291, 15.7%), FPG >= 9.1 mmol/l. The primary end point was in-hospital and 3-year all-cause mortality from the day of admission.

Results Compared with the euglycaemia group, hypoglycaemia or hyperglycaemia groups were all associated with higher in-hospital and 3-year all-cause mortality. There was a U-shaped relationship between admission FPG levels and short- and long-term all-cause mortality. This U-shaped relationship applied equally to subgroups in the context of contemporary treatments.

Conclusions In older patients with AMI, increased as well as decreased admission FPG levels could predict higher in-hospital and 3-year mortality. There was a striking U-shaped relationship between admission FPG levels and short-and long-term mortality. An initial admission FPG level >= 5.1 to <= 7.0 mmol/l may be desirable because it was associated with better clinical outcomes.

语种英语
所属项目编号Z0005190042811
资助者Beijing Municipal Science and Technology Commission ; Beijing Municipal Science and Technology Commission
WOS记录号WOS:000281666900005
Citation statistics
Cited Times:22[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57059
Collection北京大学第二临床医学院_心血管内科
作者单位1.Gen Hosp Beijing Millitary, Dept Cardiol, Beijing, Peoples R China
2.Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
4.Capital Med Univ, Beijing Xuanwu Hosp, Dept Cardiol, Beijing 100029, Peoples R China
5.Capital Med Univ, Beijing Friendship Hosp, Dept Cardiol, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Yang, Shi-Wei,Zhou, Yu-Jie,Hu, Da-Yi,et al. Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction[J]. HEART,2010,96(18):1444-1450.
APA Yang, Shi-Wei.,Zhou, Yu-Jie.,Hu, Da-Yi.,Nie, Xiao-Min.,Liu, Yu-Yang.,...&BEAMIS Study Grp.(2010).Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction.HEART,96(18),1444-1450.
MLA Yang, Shi-Wei,et al."Association between admission hypoglycaemia and in-hospital and 3-year mortality in older patients with acute myocardial infarction".HEART 96.18(2010):1444-1450.
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