北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学深圳医院  > 生殖医学科  > 期刊论文
学科主题: 临床医学
题名:
Sexual dimorphism and regulation of resistin, adiponectin, and leptin expression in the mouse
作者: Gui, YT; Silha, JV; Murphy, LJ
关键词: sexual dimorphism ; resistin ; adiponectin ; leptin ; estrous cycle
刊名: OBESITY RESEARCH
发表日期: 2004-09-01
卷: 12, 期:9, 页:1481-1491
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Nutrition & Dietetics
研究领域[WOS]: Endocrinology & Metabolism ; Nutrition & Dietetics
关键词[WOS]: INSULIN-RESISTANCE ; ADIPOSE-TISSUE ; ESTROUS-CYCLE ; ENERGY HOMEOSTASIS ; STEROID-HORMONES ; GENE-EXPRESSION ; PLASMA LEPTIN ; RAT ; RECEPTOR ; OBESITY
英文摘要:

Objective: To examine gender differences and hormonal regulation of resistin, adiponectin, and leptin.

Research Methods and Procedures: Plasma levels were measured, and mRNA expression in perigonadal fat was quantified by RNase protection assays.

Results: Plasma resistin declined with age despite an increase in adiposity in both genders. In male mice, plasma leptin increased, whereas adiponectin levels were constant. In females, both adiponectin and leptin levels increased with age. Resistin mRNA levels were significantly higher in female than male mice at all ages, whereas leptin and adiponectin mRNA levels were similar in fat from 6-week-old male and female mice, and sexual dimorphism was apparent only in the older mice, with higher levels apparent in females. Castration did not abolish gender differences in plasma levels or resistin, adiponectin, or leptin mRNAs. Castration of male mice did not significantly change adipokine mRNA levels or plasma levels of resistin or leptin; however, adiponectin was significantly increased. Dihydrotestosterone treatment had no effect on adipokine mRNA expression or resistin and adiponectin levels but increased leptin levels. In contrast, ovariectomy significantly increased resistin mRNA abundance and decreased leptin and adiponectin mRNAs. Plasma leptin levels were also increased by ovariectomy, whereas resistin and adiponectin levels were unchanged. Estrogen replacement significantly reduced resistin mRNA and increased leptin and adiponectin mRNA levels but had no effect on plasma adipokine levels.

Discussion: The gender differences in adipokine mRNA expression and plasma levels were not ablated by castration and seem to be dependent on other factors in addition to gonadal steroids.

语种: 英语
WOS记录号: WOS:000224509700015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57060
Appears in Collections:北京大学深圳医院_生殖医学科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Manitoba, Dept Physiol & Med, Winnipeg, MB R3E 0W3, Canada
2.Peking Univ, Shenzhen Hosp, Ctr Reprod Med, Shenzhen, Peoples R China

Recommended Citation:
Gui, YT,Silha, JV,Murphy, LJ. Sexual dimorphism and regulation of resistin, adiponectin, and leptin expression in the mouse[J]. OBESITY RESEARCH,2004,12(9):1481-1491.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gui, YT]'s Articles
[Silha, JV]'s Articles
[Murphy, LJ]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gui, YT]‘s Articles
[Silha, JV]‘s Articles
[Murphy, LJ]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace