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学科主题: 基础医学
题名:
Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases
作者: Shi, XY; Gong, EC; Gao, DX; Zhang, B; Zheng, J; Gao, ZF; Zhong, YF; Zou, WZ; Wu, BQ; Fang, WG; Liao, SL; Wang, SL; Xie, ZG; Lu, M; Hou, L; Zhong, HH; Shao, HQ; Li, N; Liu, CR; Pei, F; Yang, JP; Wang, YP; Han, ZH; Shi, XH; Zhang, QY; You, JF; Zhu, X; Gu, J
刊名: AMERICAN JOURNAL OF GASTROENTEROLOGY
发表日期: 2005
DOI: 10.1111/j.1572-0241.2005.40377.x
卷: 100, 期:1, 页:169-176
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: ANTIBIOTIC-ASSOCIATED DIARRHEA ; IN-SITU HYBRIDIZATION ; TRANSMISSIBLE GASTROENTERITIS ; HONG-KONG ; VIRAL-ENTERITIS ; SYNDROME SARS ; INFECTION ; OUTBREAK ; DETERMINANTS ; LYMPHOCYTES
英文摘要:

OBJECTIVES: A significant percentage of confirmed severe acute respiratory syndrome (SARS) patients experienced gastrointestinal symptoms, and the viral sequence was detectable in the stool of most patients. At present, the knowledge of the pathology of the digestive system in SARS patients is limited. Because a resurgence of the SARS epidemic is constantly possible, there is an urgent need to understand the involvement of the digestive system in this new disease.

METHODS: We performed seven SARS autopsies in which samples of alimentary tract and digestive glands were examined with routine pathology, electron microscopy (EM), in situ hybridization (ISH), immunohistochemistry, and real-time polymerase chain reaction (PCR).

RESULTS: The main histopathological finding was atrophy of the mucosal lymphoid tissue. A few mucosal epithelial cells and lymphocytes in the intestine were positively stained for coronavirus with ISH. SARS-coronavirus (CoV)-like particles were found in the mucosal epithelial cells under EM and mild focal inflammation was detected in the alimentary tract. One patient who experienced severe diarrhea had pseudomembranous enteritis of the ileum. Fatty degeneration and central lobular necrosis were observed in the liver. No evidence of direct viral infection was found in the esophagus, the stomach, the salivary gland, the liver, or the pancreas.

CONCLUSIONS: In addition to the lungs, the gastrointestinal tract is another target of SARS-CoV infection, as the intestinal epithelial cells and mucosal lymphoid tissue are infected. The findings provide possible explanations for the gastrointestinal symptoms and the presence of virus in the stool of SARS patients.

语种: 英语
WOS记录号: WOS:000226033100027
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57061
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp, Hlth Sci Ctr, Beijing, Peoples R China
2.Beijing Ditan Hosp, Beijing, Peoples R China
3.Peking Univ, Dept Pathol, Sch Basic Med Sci, Hlth Sci Ctr, Beijing 100083, Peoples R China

Recommended Citation:
Shi, XY,Gong, EC,Gao, DX,et al. Severe acute respiratory syndrome associated coronavirus is detected in intestinal tissues of fatal cases[J]. AMERICAN JOURNAL OF GASTROENTEROLOGY,2005,100(1):169-176.
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