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学科主题: 口腔医学
题名:
Osteoconductive effectiveness of bone graft derived from antler cancellous bone: an experimental study in the rabbit mandible defect model
作者: Zhang, X.1,2; Cai, Q.3; Liu, H.4; Heng, B. C.5; Peng, H.1; Song, Y.2; Yang, Z.2; Deng, X.1
关键词: antler ; bone graft ; bone defect repair ; osteoconductivity ; vascularization
刊名: INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
发表日期: 2012-11-01
DOI: 10.1016/j.ijom.2012.05.014
卷: 41, 期:11, 页:1330-1337
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]: Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]: IN-VITRO ; PHYSICOCHEMICAL CHARACTERIZATION ; OSTEOGENIC DIFFERENTIATION ; MECHANICAL-PROPERTIES ; CRITICAL SIZE ; BIO-OSS ; REGENERATION ; SCAFFOLDS ; REPAIR ; SUBSTITUTES
英文摘要:

The purpose of this study was to evaluate the properties of a novel inorganic xenogenic bone substitute, calcinated antler cancellous bone (CACB). Physicochemical properties of CACB including surface morphology, phase composition, chemical bond structure, Ca/P ratio and porosity were characterized by scanning electron microscopy, X-ray diffraction spectroscopy, Fourier-transform infrared spectroscopy, inductively coupled plasma-atomic emission spectroscopy and nitrogen adsorption analysis, and were found to closely resemble calcinated human cancellous bone. The bone defect repair efficacy of CACB was evaluated in comparison with commercially available bone substitutes (Bio-Oss (R)) within rabbit mandible defects. The gross observation, micro-CT and histology analysis data demonstrated that CACB was efficacious for bone regeneration, and was comparable with Bio-Oss (R) bone substitute in inducing neovascularization and osteogenesis within the mandible defects. CACB can therefore serve as a safe, renewable, and sustainable source of bone graft material, but without the ethical issues pertaining to animal welfare.

语种: 英语
所属项目编号: 2012CB933904 ; 81171000 ; 51073016 ; 2010DFA51500
项目资助者: National Basic Research Program of China ; National Natural Science Foundation of China ; International Science and Technology Cooperation Program ; Program of New Century Excellent Talents (NCET) of Universities in China
WOS记录号: WOS:000310412700003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57066
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
2.Jilin Univ, Coll Anim Sci & Vet Med, Changchun 130023, Jilin, Peoples R China
3.Beijing Univ Chem Technol, Minist Educ, Key Lab Carbon Fiber & Funct Polymers, Beijing, PR, Peoples R China
4.Tsinghua Univ, Dept Mat Sci & Engn, Beijing 100084, Peoples R China
5.Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland

Recommended Citation:
Zhang, X.,Cai, Q.,Liu, H.,et al. Osteoconductive effectiveness of bone graft derived from antler cancellous bone: an experimental study in the rabbit mandible defect model[J]. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2012,41(11):1330-1337.
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