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Osteoconductive effectiveness of bone graft derived from antler cancellous bone: an experimental study in the rabbit mandible defect model
Zhang, X.1,2; Cai, Q.3; Liu, H.4; Heng, B. C.5; Peng, H.1; Song, Y.2; Yang, Z.2; Deng, X.1
关键词Antler Bone Graft Bone Defect Repair Osteoconductivity Vascularization
刊名INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
2012-11-01
DOI10.1016/j.ijom.2012.05.014
41期:11页:1330-1337
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
研究领域[WOS]Dentistry, Oral Surgery & Medicine ; Surgery
关键词[WOS]IN-VITRO ; PHYSICOCHEMICAL CHARACTERIZATION ; OSTEOGENIC DIFFERENTIATION ; MECHANICAL-PROPERTIES ; CRITICAL SIZE ; BIO-OSS ; REGENERATION ; SCAFFOLDS ; REPAIR ; SUBSTITUTES
英文摘要

The purpose of this study was to evaluate the properties of a novel inorganic xenogenic bone substitute, calcinated antler cancellous bone (CACB). Physicochemical properties of CACB including surface morphology, phase composition, chemical bond structure, Ca/P ratio and porosity were characterized by scanning electron microscopy, X-ray diffraction spectroscopy, Fourier-transform infrared spectroscopy, inductively coupled plasma-atomic emission spectroscopy and nitrogen adsorption analysis, and were found to closely resemble calcinated human cancellous bone. The bone defect repair efficacy of CACB was evaluated in comparison with commercially available bone substitutes (Bio-Oss (R)) within rabbit mandible defects. The gross observation, micro-CT and histology analysis data demonstrated that CACB was efficacious for bone regeneration, and was comparable with Bio-Oss (R) bone substitute in inducing neovascularization and osteogenesis within the mandible defects. CACB can therefore serve as a safe, renewable, and sustainable source of bone graft material, but without the ethical issues pertaining to animal welfare.

语种英语
WOS记录号WOS:000310412700003
项目编号2012CB933904 ; 81171000 ; 51073016 ; 2010DFA51500
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; International Science and Technology Cooperation Program ; Program of New Century Excellent Talents (NCET) of Universities in China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57066
专题北京大学口腔医学院
北京大学第一临床医学院_神经内科
北京大学口腔医学院_第三门诊部
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
2.Jilin Univ, Coll Anim Sci & Vet Med, Changchun 130023, Jilin, Peoples R China
3.Beijing Univ Chem Technol, Minist Educ, Key Lab Carbon Fiber & Funct Polymers, Beijing, PR, Peoples R China
4.Tsinghua Univ, Dept Mat Sci & Engn, Beijing 100084, Peoples R China
5.Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland
推荐引用方式
GB/T 7714
Zhang, X.,Cai, Q.,Liu, H.,et al. Osteoconductive effectiveness of bone graft derived from antler cancellous bone: an experimental study in the rabbit mandible defect model[J]. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,2012,41(11):1330-1337.
APA Zhang, X..,Cai, Q..,Liu, H..,Heng, B. C..,Peng, H..,...&Deng, X..(2012).Osteoconductive effectiveness of bone graft derived from antler cancellous bone: an experimental study in the rabbit mandible defect model.INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY,41(11),1330-1337.
MLA Zhang, X.,et al."Osteoconductive effectiveness of bone graft derived from antler cancellous bone: an experimental study in the rabbit mandible defect model".INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY 41.11(2012):1330-1337.
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