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IR@PKUHSC  > 北京大学第二临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Clinical Findings in 111 Cases of Influenza A (H7N9) Virus Infection
作者: Gao, Hai-Nv1; Lu, Hong-Zhou3; Cao, Bin13; Du, Bin14; Shang, Hong19; Gan, Jian-He20; Lu, Shui-Hua3; Yang, Yi-Da1; Fang, Qiang1; Shen, Yin-Zhong3; Xi, Xiu-Ming15; Gu, Qin21; Zhou, Xian-Mei22; Qu, Hong-Ping4; Yan, Zheng25; Li, Fang-Ming5; Zhao, Wei23; Gao, Zhan-Cheng16; Wang, Guang-Fa17; Ruan, Ling-Xiang1; Wang, Wei-Hong2; Ye, Jun6; Cao, Hui-Fang7; Li, Xing-Wang18; Zhang, Wen-Hong8; Fang, Xu-Chen9; He, Jian10; Liang, Wei-Feng1; Xie, Juan5; Zeng, Mei11; Wu, Xian-Zheng12; Li, Jun24; Xia, Qi1; Jin, Zhao-Chen26; Chen, Qi27; Tang, Chao28; Zhang, Zhi-Yong3; Hou, Bao-Min29; Feng, Zhi-Xian1; Sheng, Ji-Fang1; Zhong, Nan-Shan30; Li, Lan-Juan1
刊名: NEW ENGLAND JOURNAL OF MEDICINE
发表日期: 2013-06-13
DOI: 10.1056/NEJMoa1305584
卷: 368, 期:24, 页:2277-2285
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: H5N1 ; THAILAND ; HUMANS ; CHINA
英文摘要:

BACKGROUND

During the spring of 2013, a novel avian-origin influenza A (H7N9) virus emerged and spread among humans in China. Data were lacking on the clinical characteristics of the infections caused by this virus.

METHODS

Using medical charts, we collected data on 111 patients with laboratory-confirmed avian-origin influenza A (H7N9) infection through May 10, 2013.

RESULTS

Of the 111 patients we studied, 76.6% were admitted to an intensive care unit (ICU), and 27.0% died. The median age was 61 years, and 42.3% were 65 years of age or older; 31.5% were female. A total of 61.3% of the patients had at least one underlying medical condition. Fever and cough were the most common presenting symptoms. On admission, 108 patients (97.3%) had findings consistent with pneumonia. Bilateral ground-glass opacities and consolidation were the typical radiologic findings. Lymphocytopenia was observed in 88.3% of patients, and thrombo-cytopenia in 73.0%. Treatment with antiviral drugs was initiated in 108 patients (97.3%) at a median of 7 days after the onset of illness. The median times from the onset of illness and from the initiation of antiviral therapy to a negative viral test result on real-time reverse-transcriptase-polymerase-chain-reaction assay were 11 days (interquartile range, 9 to 16) and 6 days (interquartile range, 4 to 7), respectively. Multivariate analysis revealed that the presence of a coexisting medical condition was the only independent risk factor for the acute respiratory distress syndrome (ARDS) (odds ratio, 3.42; 95% confidence interval, 1.21 to 9.70; P = 0.02).

CONCLUSIONS

During the evaluation period, the novel H7N9 virus caused severe illness, including pneumonia and ARDS, with high rates of ICU admission and death. (Funded by the National Natural Science Foundation of China and others.)

语种: 英语
所属项目编号: 81070005/H0104 ; 81030032/H19 ; KJYJ-2013-01 ; 2012ZX10004-206 ; 2012ZX10004-210
项目资助者: National Natural Science Foundation of China ; National Program for the Prevention and Control of Human Infections by Avian-Origin H7N9 Influenza A Virus ; National Major Science and Technology Research Projects for the Control and Prevention of Major Infectious Diseases in China
WOS记录号: WOS:000320230500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57068
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
2.China Med Univ, Hosp 1, Shenyang, Peoples R China
3.Jiangsu Prov Hosp Tradit Chinese Med, Nanjing, Jiangsu, Peoples R China
4.First Hosp Zhenjiang, Zhenjiang, Peoples R China
5.First Hosp Yancheng, Yancheng, Peoples R China
6.Peoples Hosp Bozhou, Bozhou, Peoples R China
7.Zhoukou Infect Dis Hosp, Zhoukou, Peoples R China
8.Huzhou Cent Hosp, Huzhou, Peoples R China
9.Fifth Hosp Shanghai, Shanghai, Peoples R China
10.Jingan Dist Cent Hosp, Shanghai, Peoples R China
11.Yangpu Dist Shidong Hosp Shanghai, Shanghai, Peoples R China
12.Fudan Univ, Childrens Hosp, Shanghai 200433, Peoples R China
13.Tongji Univ, Tongji Hosp, Shanghai 200092, Peoples R China
14.Capital Med Univ, Fuxing Hosp, Beijing, Peoples R China
15.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
16.Zhejiang Univ, Affiliated Coll Med 1, Dept Infect Dis, State Key Lab Diag & Treatment Infect Dis, Hangzhou 310003, Zhejiang, Peoples R China
17.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai 200433, Peoples R China
18.Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Shanghai 200030, Peoples R China
19.Shanghai Univ Tradit Chinese Med, Putuo Hosp, Shanghai, Peoples R China
20.Fudan Univ, Huashan Hosp, Dept Infect Dis, Shanghai 200433, Peoples R China
21.Second Mil Med Univ, Changhai Hosp, Shanghai, Peoples R China
22.Capital Med Univ, Beijing Chao Yang Hosp, Beijing Inst Resp Med, Dept Infect Dis & Clin Microbiol, Beijing, Peoples R China
23.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Med Intens Care Unit, Beijing 100730, Peoples R China
24.Capital Med Univ, Beijing Ditan Hosp, Inst Infect Dis, Beijing, Peoples R China
25.Soochow Univ, Coll Med, Affiliated Hosp 1, Suzhou, Peoples R China
26.Nanjing Univ, Sch Med, Affiliated Hosp, Nanjing Drum Tower Hosp, Nanjing 210008, Jiangsu, Peoples R China
27.Southeast Univ, Affiliated Hosp 2, Nanjing, Jiangsu, Peoples R China
28.Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China
29.Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Wuxi, Peoples R China
30.Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou Inst Resp Dis, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Gao, Hai-Nv,Lu, Hong-Zhou,Cao, Bin,et al. Clinical Findings in 111 Cases of Influenza A (H7N9) Virus Infection[J]. NEW ENGLAND JOURNAL OF MEDICINE,2013,368(24):2277-2285.
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