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学科主题: 公共卫生
题名:
Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population
作者: Yuan, Yue1,2; Jin, Lei1,2; Wang, Linlin1,2; Li, Zhiwen1,2; Zhang, Le1,2; Zhu, Huiping3; Finnell, Richard H.3; Zhou, Guodong4; Ren, Aiguo1,2
关键词: Polycyclic aromatic hydrocarbons (PAHs) ; DNA adducts ; Neural tube defects (NTDs) ; Placenta ; Fetus
刊名: REPRODUCTIVE TOXICOLOGY
发表日期: 2013-06-01
DOI: 10.1016/j.reprotox.2013.01.008
卷: 37, 页:70-75
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Reproductive Biology ; Toxicology
研究领域[WOS]: Reproductive Biology ; Toxicology
关键词[WOS]: POLYCYCLIC AROMATIC-HYDROCARBONS ; MATERNAL OCCUPATIONAL-EXPOSURE ; CORD BLOOD ; ENVIRONMENTAL-POLLUTANTS ; TRANSPLACENTAL TRANSFER ; PRENATAL EXPOSURE ; SHANXI PROVINCE ; TOBACCO-SMOKE ; CANCER ; ASSOCIATION
英文摘要:

We examined the relationship between PAH-DNA adduct levels in the placental tissue, measured by a highly sensitive P-32-postlabeling assay, and the risk of fetal neural tube defects (NTDs). We further explored the interaction between PAH-DNA adducts and placental PAHs with respect to NTD risk. Placental tissues from 80 NTD-affected pregnancies and 50 uncomplicated normal pregnancies were included in this case-control study. Levels of PAH-DNA adducts were lower in the NTD group (8.12 per 10(8) nucleotides) compared to controls (9.92 per 10(8) nucleotides). PAH-DNA adduct concentrations below the median was associated with a 3-fold increased NTD risk. Women with a low PAH-DNA adduct level in concert with a high placental PAH level resulted in a 10-fold elevated risk of having an NTD-complicated pregnancy. A low level of placental PAH-DNA adducts was associated with an increased risk of NTDs; this risk increased dramatically when a low adduct level was coupled with a high placental PAH concentration. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 31071315 ; ES021006
项目资助者: National Natural Science Foundation of China ; NIH
WOS记录号: WOS:000317254100010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57069
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Inst Reprod & Child Hlth, Key Lab Reprod Hlth, Beijing 100191, Peoples R China
3.Univ Texas Austin, Dept Nutr Sci, Dell Pediat Res Inst, Austin, TX 78723 USA
4.Texas A&M Univ, Hlth Sci Ctr, Inst Biosci & Technol, Houston, TX 77030 USA

Recommended Citation:
Yuan, Yue,Jin, Lei,Wang, Linlin,et al. Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population[J]. REPRODUCTIVE TOXICOLOGY,2013,37:70-75.
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