IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population
Yuan, Yue1,2; Jin, Lei1,2; Wang, Linlin1,2; Li, Zhiwen1,2; Zhang, Le1,2; Zhu, Huiping3; Finnell, Richard H.3; Zhou, Guodong4; Ren, Aiguo1,2
关键词Polycyclic Aromatic Hydrocarbons (Pahs) Dna Adducts Neural Tube Defects (Ntds) Placenta Fetus
刊名REPRODUCTIVE TOXICOLOGY
2013-06-01
DOI10.1016/j.reprotox.2013.01.008
37页:70-75
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Reproductive Biology ; Toxicology
研究领域[WOS]Reproductive Biology ; Toxicology
关键词[WOS]POLYCYCLIC AROMATIC-HYDROCARBONS ; MATERNAL OCCUPATIONAL-EXPOSURE ; CORD BLOOD ; ENVIRONMENTAL-POLLUTANTS ; TRANSPLACENTAL TRANSFER ; PRENATAL EXPOSURE ; SHANXI PROVINCE ; TOBACCO-SMOKE ; CANCER ; ASSOCIATION
英文摘要

We examined the relationship between PAH-DNA adduct levels in the placental tissue, measured by a highly sensitive P-32-postlabeling assay, and the risk of fetal neural tube defects (NTDs). We further explored the interaction between PAH-DNA adducts and placental PAHs with respect to NTD risk. Placental tissues from 80 NTD-affected pregnancies and 50 uncomplicated normal pregnancies were included in this case-control study. Levels of PAH-DNA adducts were lower in the NTD group (8.12 per 10(8) nucleotides) compared to controls (9.92 per 10(8) nucleotides). PAH-DNA adduct concentrations below the median was associated with a 3-fold increased NTD risk. Women with a low PAH-DNA adduct level in concert with a high placental PAH level resulted in a 10-fold elevated risk of having an NTD-complicated pregnancy. A low level of placental PAH-DNA adducts was associated with an increased risk of NTDs; this risk increased dramatically when a low adduct level was coupled with a high placental PAH concentration. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000317254100010
项目编号31071315 ; ES021006
资助机构National Natural Science Foundation of China ; NIH
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57069
专题北京大学公共卫生学院
北京大学医学部管理机构_医学部
北京大学公共卫生学院_卫计委生育健康重点实验室
作者单位1.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Hlth Stat, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Inst Reprod & Child Hlth, Key Lab Reprod Hlth, Beijing 100191, Peoples R China
3.Univ Texas Austin, Dept Nutr Sci, Dell Pediat Res Inst, Austin, TX 78723 USA
4.Texas A&M Univ, Hlth Sci Ctr, Inst Biosci & Technol, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Yuan, Yue,Jin, Lei,Wang, Linlin,et al. Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population[J]. REPRODUCTIVE TOXICOLOGY,2013,37:70-75.
APA Yuan, Yue.,Jin, Lei.,Wang, Linlin.,Li, Zhiwen.,Zhang, Le.,...&Ren, Aiguo.(2013).Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population.REPRODUCTIVE TOXICOLOGY,37,70-75.
MLA Yuan, Yue,et al."Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population".REPRODUCTIVE TOXICOLOGY 37(2013):70-75.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yuan, Yue]的文章
[Jin, Lei]的文章
[Wang, Linlin]的文章
百度学术
百度学术中相似的文章
[Yuan, Yue]的文章
[Jin, Lei]的文章
[Wang, Linlin]的文章
必应学术
必应学术中相似的文章
[Yuan, Yue]的文章
[Jin, Lei]的文章
[Wang, Linlin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。