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学科主题: 临床医学
题名:
Contribution of PD-L1 to oncogenesis of lymphoma and its RNAi-based targeting therapy
作者: Li, Yi1,2; Wang, Jing1,2; Li, Chong3; Ke, Xiao-Yan1,2
关键词: PD-L1 ; lymphoma ; costimulatory signal ; therapy
刊名: LEUKEMIA & LYMPHOMA
发表日期: 2012-10-01
DOI: 10.3109/10428194.2012.673228
卷: 53, 期:10, 页:2015-2023
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology
研究领域[WOS]: Oncology ; Hematology
关键词[WOS]: T-CELL APOPTOSIS ; CANCER ; B7-H1 ; EXPRESSION ; LIGANDS ; CARCINOMA ; ANTIBODY ; IMMUNITY ; MOLECULES ; BLOCKADE
英文摘要:

Lymphomas are common malignancies that are prevalent worldwide. In recent years, some types of lymphoma have become curable, but relapsed and refractory lymphomas remain common and challenging. Impaired host immunity and therapeutic resistance are thought to play pivotal roles in the pathogenesis and progression of lymphomas. PD-L1 (programmed death ligand 1) is a newly discovered member of the B7 family of molecules, and its receptor is PD-1. It is known that the costimulatory signal of PD-1 and PD-L1 can help tumor escape from cellular immunity. However, little is known of the impact of PD-L1 on tumor cells, especially lymphomas. Our investigation shows for the first time that: (1) PD-L1 has a vital role in lymphoma oncogenesis; (2) the down-regulation of PD-L1 combined with chemotherapy can significantly suppress lymphoma growth, promote antitumor activity and prolong the survival rate; and (3) targeted therapy of PD-L1 may provide a new and promising approach to the treatment of lymphomas.

语种: 英语
所属项目编号: 81172245
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000323371200014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57072
Appears in Collections:北京大学第三临床医学院_血液内科_期刊论文

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作者单位: 1.Peking Univ, Dept Hematol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Lymphoma Res Ctr, Hosp 3, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Biophys, CAS Key Lab Infect & Immun, Beijing 100080, Peoples R China

Recommended Citation:
Li, Yi,Wang, Jing,Li, Chong,et al. Contribution of PD-L1 to oncogenesis of lymphoma and its RNAi-based targeting therapy[J]. LEUKEMIA & LYMPHOMA,2012,53(10):2015-2023.
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