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学科主题临床医学
Contribution of PD-L1 to oncogenesis of lymphoma and its RNAi-based targeting therapy
Li, Yi1,2; Wang, Jing1,2; Li, Chong3; Ke, Xiao-Yan1,2
关键词Pd-l1 Lymphoma Costimulatory Signal Therapy
刊名LEUKEMIA & LYMPHOMA
2012-10-01
DOI10.3109/10428194.2012.673228
53期:10页:2015-2023
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]T-CELL APOPTOSIS ; CANCER ; B7-H1 ; EXPRESSION ; LIGANDS ; CARCINOMA ; ANTIBODY ; IMMUNITY ; MOLECULES ; BLOCKADE
英文摘要

Lymphomas are common malignancies that are prevalent worldwide. In recent years, some types of lymphoma have become curable, but relapsed and refractory lymphomas remain common and challenging. Impaired host immunity and therapeutic resistance are thought to play pivotal roles in the pathogenesis and progression of lymphomas. PD-L1 (programmed death ligand 1) is a newly discovered member of the B7 family of molecules, and its receptor is PD-1. It is known that the costimulatory signal of PD-1 and PD-L1 can help tumor escape from cellular immunity. However, little is known of the impact of PD-L1 on tumor cells, especially lymphomas. Our investigation shows for the first time that: (1) PD-L1 has a vital role in lymphoma oncogenesis; (2) the down-regulation of PD-L1 combined with chemotherapy can significantly suppress lymphoma growth, promote antitumor activity and prolong the survival rate; and (3) targeted therapy of PD-L1 may provide a new and promising approach to the treatment of lymphomas.

语种英语
WOS记录号WOS:000323371200014
项目编号81172245
资助机构National Natural Science Foundation of China
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57072
专题北京大学第三临床医学院_血液内科
北京大学第二临床医学院_血液科
作者单位1.Peking Univ, Dept Hematol, Hosp 3, Beijing 100191, Peoples R China
2.Peking Univ, Lymphoma Res Ctr, Hosp 3, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Biophys, CAS Key Lab Infect & Immun, Beijing 100080, Peoples R China
推荐引用方式
GB/T 7714
Li, Yi,Wang, Jing,Li, Chong,et al. Contribution of PD-L1 to oncogenesis of lymphoma and its RNAi-based targeting therapy[J]. LEUKEMIA & LYMPHOMA,2012,53(10):2015-2023.
APA Li, Yi,Wang, Jing,Li, Chong,&Ke, Xiao-Yan.(2012).Contribution of PD-L1 to oncogenesis of lymphoma and its RNAi-based targeting therapy.LEUKEMIA & LYMPHOMA,53(10),2015-2023.
MLA Li, Yi,et al."Contribution of PD-L1 to oncogenesis of lymphoma and its RNAi-based targeting therapy".LEUKEMIA & LYMPHOMA 53.10(2012):2015-2023.
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