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Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water
Wang, Zhong-qing; Ge, Ze-mei; Cheng, Tie-ming; Li, Run-tao
关键词Multicomponent Reactions S-alkylisothiouronium Salts 2-amino-4-aryl(Alkyl)-6-sulfanyl Pyridine-3 Thiols 5-dicarbonitrile Green Chemistry
刊名SYNLETT
2009-07-22
DOI10.1055/s-0029-1217529
12页:2020-2022
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]MULTICOMPONENT REACTIONS ; DRUG DISCOVERY ; PRION DISEASE ; ONE-STEP ; DICARBONITRILES ; CHEMISTRY ; ADENOSINE ; RECEPTOR ; LIBRARY ; PROFILE
英文摘要

A novel methodology for the synthesis of 2-amino-4-aryl(alkyl)-6-sulfanyl pyridine-3,5-dicarbonitriles via a one-pot, three-component reaction of structurally diversified aldehydes with various S-alkylisothiouronium salts and malononitrile in water has been developed. Utilization of S-alkylisothiouronium salts as thiol equivalents greatly broadens the application of the current method, and also makes the reaction more environmentally friendly.

语种英语
WOS记录号WOS:000269337500028
项目编号20672009 ; 2007BAI34B00
资助机构Natural Science Foundation of China (NSFC) ; National Key Technology RD Program
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57074
专题北京大学药学院
北京大学药学院_化学生物学系
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wang, Zhong-qing,Ge, Ze-mei,Cheng, Tie-ming,et al. Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water[J]. SYNLETT,2009(12):2020-2022.
APA Wang, Zhong-qing,Ge, Ze-mei,Cheng, Tie-ming,&Li, Run-tao.(2009).Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water.SYNLETT(12),2020-2022.
MLA Wang, Zhong-qing,et al."Synthesis of Highly Substituted Pyridines via a One-Pot, Three-Component Cascade Reaction of Malononitrile with Aldehydes and S-Alkylisothiouronium Salts in Water".SYNLETT .12(2009):2020-2022.
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