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学科主题: 基础医学
题名:
Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion
作者: Han, Jing-Yan1,2,3; Fan, Jing-Yu2; Horie, Yoshinori3; Miura, Soichiro4; Cui, De-Hua5; Ishii, Hiromasa3; Hibi, Toshifumi3; Tsuneki, Hiroshi6; Kimura, Ikuko7
关键词: salvia miltiorrhiza root extract ; ischemia and reperfusion ; organ injury ; antioxidation ; adhesion molecules ; mast cell degranulation ; platelet aggregation
刊名: PHARMACOLOGY & THERAPEUTICS
发表日期: 2008-02-01
DOI: 10.1016/j.pharmthera.2007.09.008
卷: 117, 期:2, 页:280-295
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: ACUTE MYOCARDIAL-INFARCTION ; NITRIC-OXIDE SYNTHASE ; NECROSIS-FACTOR-ALPHA ; ENDOTHELIAL-CELL-ADHESION ; NF-KAPPA-B ; INDUCED MICROVASCULAR DYSFUNCTION ; TRADITIONAL CHINESE MEDICINE ; INDUCED OXIDATIVE STRESS ; FOCAL CEREBRAL-ISCHEMIA ; HEPATIC STELLATE CELLS
英文摘要:

Ischemia and reperfusion (I/R) exerts multiple insults in microcirculation, frequently accompanied by endothelial cell injury, enhanced adhesion of leukocytes, macromolecular efflux, production of oxygen free radicals, and mast cell degranulation. Since the microcirculatory disturbance results in injury of organ involved, protection of organ after I/R is of great importance in clinic. Salvia miltiorrhiza root has long been used in Asian countries for clinical treatment of various microcirculatory disturbance-related diseases. This herbal drug contains many active water-soluble compounds, including protocatechuic aldehyde (PA1), 3,4-dihydroxyphenyl lactic acid (DLA) and salvianolic acid B (SaiB). These compounds, as well as water-soluble fraction of S. miltiorrhiza root extract (SMRE), have an ability to scavenge peroxides and are able to inhibit the expression of adhesion molecules in vascular endothelium and leukocytes. Moreover, lipophilic compounds of SMRE also prevent the development of vascular damage; NADPH oxidase and platelet aggregation are inhibited by tanshinone IIA and tanshinone 1113, respectively, and the mast cell degranulation is blunted by cryptotanshinone and 15,16-dihydrotanshinone I. Thus, the water-soluble and lipophilic compounds of SMRE appear to improve the I/R-induced vascular damage multifactorially and synergically. This review will summarize the ameliorating effect of compounds derived from SMRE on microcirculatory disturbance and target organ injury after I/R and will provide a new perspective on remedy with multiple drugs. (C) 2007 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000253362800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57078
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Keio Univ, Sch Med, Dept Internal Med, Tokyo, Japan
2.Toyama Univ, Dept Clin Pharmacol, Toyama, Japan
3.Toyama Coll, Dept Food Sci & Nutr, Toyama, Japan
4.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100083, Peoples R China
5.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing, Peoples R China
6.Natl Def Med Coll, Dept Internal Med, Tokorozawa, Saitama, Japan
7.Peking Univ, Neurol Res Inst, Dept Neurobiol, Beijing 100083, Peoples R China

Recommended Citation:
Han, Jing-Yan,Fan, Jing-Yu,Horie, Yoshinori,et al. Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion[J]. PHARMACOLOGY & THERAPEUTICS,2008,117(2):280-295.
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