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Evolution of Carbapenem-Resistant Acinetobacter baumannii Revealed through Whole-Genome Sequencing and Comparative Genomic Analysis
Li, Henan1; Liu, Fei2; Zhang, Yawei1; Wang, Xiaojuan1; Zhao, Chunjiang1; Chen, Hongbin1; Zhang, Feifei1; Zhu, Baoli2; Hu, Yongfei2; Wang, Hui1
刊名ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
2015-02-01
DOI10.1128/AAC.04609-14
59期:2页:1168-1176
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Microbiology ; Pharmacology & Pharmacy
研究领域[WOS]Microbiology ; Pharmacology & Pharmacy
关键词[WOS]ENCODING PHOSPHOGLUCOSAMINE MUTASE ; RESTRICTION-MODIFICATION SYSTEMS ; VI SECRETION SYSTEM ; MULTIDRUG-RESISTANCE ; BIOFILM FORMATION ; GLMM GENE ; RNA GENES ; STRAINS ; ISLANDS ; IDENTIFICATION
英文摘要

Acinetobacter baumannii is a globally important nosocomial pathogen characterized by an evolving multidrug resistance. A total of 35 representative clinical A. baumannii strains isolated from 13 hospitals in nine cities in China from 1999 to 2011, including 32 carbapenem-resistant and 3 carbapenem-susceptible A. baumannii strains, were selected for whole-genome sequencing and comparative genomic analysis. Phylogenetic analysis revealed that the earliest strain, strain 1999BJAB11, and two strains isolated in Zhejiang Province in 2004 were the founder strains of carbapenem-resistant A. baumannii. Ten types of AbaR resistance islands were identified, and a previously unreported AbaR island, which comprised a two-component response regulator, resistance-related proteins, and RND efflux system proteins, was identified in two strains isolated in Zhejiang in 2004. Multiple transposons or insertion sequences (ISs) existed in each strain, and these gradually tended to diversify with evolution. Some of these IS elements or transposons were the first to be reported, and most of them were mainly found in strains from two provinces. Genome feature analysis illustrated diversified resistance genes, surface polysaccharides, and a restriction-modification system, even in strains that were phylogenetically and epidemiologically very closely related. IS-mediated deletions were identified in the type VI secretion system region, the csuE region, and core lipooligosaccharide (LOS) loci. Recombination occurred in the heme utilization region, and intrinsic resistance genes (blaADC and blaOXA-51-like variants) and three novel blaOXA-51-like variants (blaOXA-424, blaOXA-425, and blaOXA-426) were identified. Our results could improve the understanding of the evolutionary processes that contribute to the emergence of carbapenem-resistant A. baumannii strains and help elucidate the molecular evolutionary mechanism in A. baumannii.

语种英语
WOS记录号WOS:000348610000050
项目编号31170125 ; 5122041 ; 20110001110043 ; 2012EP001002
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Specialized Research Fund for the Doctoral Program of Higher Education ; Key Projects in the National Science &amp ; Technology Pillar Program
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57082
专题北京大学第二临床医学院
北京大学第二临床医学院_检验科
作者单位1.Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, Key Lab Pathogen Microbiol & Immunol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Li, Henan,Liu, Fei,Zhang, Yawei,et al. Evolution of Carbapenem-Resistant Acinetobacter baumannii Revealed through Whole-Genome Sequencing and Comparative Genomic Analysis[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,2015,59(2):1168-1176.
APA Li, Henan.,Liu, Fei.,Zhang, Yawei.,Wang, Xiaojuan.,Zhao, Chunjiang.,...&Wang, Hui.(2015).Evolution of Carbapenem-Resistant Acinetobacter baumannii Revealed through Whole-Genome Sequencing and Comparative Genomic Analysis.ANTIMICROBIAL AGENTS AND CHEMOTHERAPY,59(2),1168-1176.
MLA Li, Henan,et al."Evolution of Carbapenem-Resistant Acinetobacter baumannii Revealed through Whole-Genome Sequencing and Comparative Genomic Analysis".ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 59.2(2015):1168-1176.
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