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学科主题: 临床医学
题名:
Plasma H2S predicts coronary artery lesions in children with Kawasaki disease
作者: Sun, Yan1; Yuan, Yue2; Yan, Hui1; Wan, Hong1; Li, Xueying3; Chen, Siyao1; Li, Hongxia1; Tang, Chaoshu4; Du, Junbao1,5; Liu, Guiying6; Jin, Hongfang1
关键词: hydrogen sulfide ; inflammation ; Kawasaki disease ; vasculitis
刊名: PEDIATRICS INTERNATIONAL
发表日期: 2015-10-01
DOI: 10.1111/ped.12631
卷: 57, 期:5, 页:840-844
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pediatrics
研究领域[WOS]: Pediatrics
关键词[WOS]: ENDOGENOUS HYDROGEN-SULFIDE ; INTRAVENOUS IMMUNOGLOBULIN ; HYPERTENSION ; PATHOGENESIS ; CELLS ; RATS ; MICE
英文摘要:

BackgroundThe aim of this study was to determine whether plasma hydrogen sulfide (H2S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD).

MethodsA prospective study was conducted on 50 KD patients and 27 healthy children. Plasma H2S was analyzed at the acute stage. Plasma H2S was detected using the sensitive electrode method, and receiver operating characteristic curve (ROC) analysis was carried out.

ResultsPlasma H2S in KD patients at the acute stage was significantly lower than that of controls. CAL patients had reduced plasma H2S at acute stage compared with the non-CAL patients. A plasma H2S cut-off of 31.2 mu mol/L provided a sensitivity of 81% and a specificity of 62.5% for predicting coronary injuries in KD. Optimal specificity and sensitivity were obtained when using plasma H2S to predict CAL in KD children.

ConclusionPlasma H2S level in the acute period is a potentially useful biomarker for predicting CAL in KD children.

语种: 英语
所属项目编号: 2011CB503904 ; 2012BA103B03 ; 30901620 ; 81121061 ; Z13110000 6813024 ; Z131107002213035
项目资助者: Major Basic Research Project of China ; National Natural Science Foundation of China ; Beijing Scientific Research and Technology Project
WOS记录号: WOS:000363763600005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57083
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiol, Beijing, Peoples R China
2.Beijing Anzhen Hosp, Dept Pediat, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
4.Beijing Childrens Hosp, Dept Pediat Cardiol, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Dept Med Stat, Beijing 100034, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China

Recommended Citation:
Sun, Yan,Yuan, Yue,Yan, Hui,et al. Plasma H2S predicts coronary artery lesions in children with Kawasaki disease[J]. PEDIATRICS INTERNATIONAL,2015,57(5):840-844.
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