IR@PKUHSC  > 北京大学第一临床医学院  > 儿科
学科主题临床医学
Plasma H2S predicts coronary artery lesions in children with Kawasaki disease
Sun, Yan1; Yuan, Yue2; Yan, Hui1; Wan, Hong1; Li, Xueying3; Chen, Siyao1; Li, Hongxia1; Tang, Chaoshu4; Du, Junbao1,5; Liu, Guiying6; Jin, Hongfang1
关键词Hydrogen Sulfide Inflammation Kawasaki Disease Vasculitis
刊名PEDIATRICS INTERNATIONAL
2015-10-01
DOI10.1111/ped.12631
57期:5页:840-844
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics
资助者Major Basic Research Project of China ; National Natural Science Foundation of China ; Beijing Scientific Research and Technology Project ; Major Basic Research Project of China ; National Natural Science Foundation of China ; Beijing Scientific Research and Technology Project
研究领域[WOS]Pediatrics
关键词[WOS]ENDOGENOUS HYDROGEN-SULFIDE ; INTRAVENOUS IMMUNOGLOBULIN ; HYPERTENSION ; PATHOGENESIS ; CELLS ; RATS ; MICE
英文摘要

BackgroundThe aim of this study was to determine whether plasma hydrogen sulfide (H2S) is a biomarker for predicting coronary artery lesions (CAL) in children with Kawasaki disease (KD).

MethodsA prospective study was conducted on 50 KD patients and 27 healthy children. Plasma H2S was analyzed at the acute stage. Plasma H2S was detected using the sensitive electrode method, and receiver operating characteristic curve (ROC) analysis was carried out.

ResultsPlasma H2S in KD patients at the acute stage was significantly lower than that of controls. CAL patients had reduced plasma H2S at acute stage compared with the non-CAL patients. A plasma H2S cut-off of 31.2 mu mol/L provided a sensitivity of 81% and a specificity of 62.5% for predicting coronary injuries in KD. Optimal specificity and sensitivity were obtained when using plasma H2S to predict CAL in KD children.

ConclusionPlasma H2S level in the acute period is a potentially useful biomarker for predicting CAL in KD children.

语种英语
所属项目编号2011CB503904 ; 2012BA103B03 ; 30901620 ; 81121061 ; Z13110000 6813024 ; Z131107002213035
资助者Major Basic Research Project of China ; National Natural Science Foundation of China ; Beijing Scientific Research and Technology Project ; Major Basic Research Project of China ; National Natural Science Foundation of China ; Beijing Scientific Research and Technology Project
WOS记录号WOS:000363763600005
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57083
Collection北京大学第一临床医学院_儿科
作者单位1.Minist Educ, Key Lab Mol Cardiol, Beijing, Peoples R China
2.Beijing Anzhen Hosp, Dept Pediat, Beijing, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
4.Beijing Childrens Hosp, Dept Pediat Cardiol, Beijing, Peoples R China
5.Peking Univ, Hosp 1, Dept Med Stat, Beijing 100034, Peoples R China
6.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Sun, Yan,Yuan, Yue,Yan, Hui,et al. Plasma H2S predicts coronary artery lesions in children with Kawasaki disease[J]. PEDIATRICS INTERNATIONAL,2015,57(5):840-844.
APA Sun, Yan.,Yuan, Yue.,Yan, Hui.,Wan, Hong.,Li, Xueying.,...&Jin, Hongfang.(2015).Plasma H2S predicts coronary artery lesions in children with Kawasaki disease.PEDIATRICS INTERNATIONAL,57(5),840-844.
MLA Sun, Yan,et al."Plasma H2S predicts coronary artery lesions in children with Kawasaki disease".PEDIATRICS INTERNATIONAL 57.5(2015):840-844.
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