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学科主题: 临床医学
题名:
c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation
作者: Yu, Hongliang1; Li, Xiaoying1; Sun, Shaoqian1; Gao, Xianshu1; Zhou, Demin2
关键词: c-Met inhibitor ; Prostate cancer cells ; Radiosensitivity
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2012-10-26
DOI: 10.1016/j.bbrc.2012.09.117
卷: 427, 期:3, 页:659-665
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: EXPRESSION ; RECEPTOR ; RADIOTHERAPY ; APOPTOSIS ; GROWTH ; CYCLE
英文摘要:

Hormone-refractory prostate cancer shows substantial resistance to most conventional therapies including radiotherapy, constitutes a key impediment to curing patients with the disease. c-Met overexpression plays a key role in prostate cancer tumorigenesis and disease progression. Here, we demonstrate that c-Met inhibition by SU11274 could significantly suppress cell survival and proliferation as well as enhance the radiosensitivity of DU145 cells. The underlying mechanisms of the effects of SU11274 on DU145 cells may include the inhibition of c-Met signaling, depolarization of the mitochondrial membrane potential, impairment of DNA repair function, abrogation of cell cycle arrest, and enhancement of cell death. Our study is the first to show the effectiveness of combining c-Met inhibition with ionizing radiation to cure hormone-refractory prostate cancer. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2010CB12300 ; 30670619 ; 81072017 ; 20932001 ; 20852001
项目资助者: National Basic Research Program of China (973 Program) ; Natural Science Foundation of China
WOS记录号: WOS:000311263200039
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57085
Appears in Collections:北京大学第一临床医学院_肿瘤化疗科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Radiat Oncol, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China

Recommended Citation:
Yu, Hongliang,Li, Xiaoying,Sun, Shaoqian,et al. c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,427(3):659-665.
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