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学科主题临床医学
c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation
Yu, Hongliang1; Li, Xiaoying1; Sun, Shaoqian1; Gao, Xianshu1; Zhou, Demin2
关键词C-met Inhibitor Prostate Cancer Cells Radiosensitivity
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2012-10-26
DOI10.1016/j.bbrc.2012.09.117
427期:3页:659-665
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]EXPRESSION ; RECEPTOR ; RADIOTHERAPY ; APOPTOSIS ; GROWTH ; CYCLE
英文摘要

Hormone-refractory prostate cancer shows substantial resistance to most conventional therapies including radiotherapy, constitutes a key impediment to curing patients with the disease. c-Met overexpression plays a key role in prostate cancer tumorigenesis and disease progression. Here, we demonstrate that c-Met inhibition by SU11274 could significantly suppress cell survival and proliferation as well as enhance the radiosensitivity of DU145 cells. The underlying mechanisms of the effects of SU11274 on DU145 cells may include the inhibition of c-Met signaling, depolarization of the mitochondrial membrane potential, impairment of DNA repair function, abrogation of cell cycle arrest, and enhancement of cell death. Our study is the first to show the effectiveness of combining c-Met inhibition with ionizing radiation to cure hormone-refractory prostate cancer. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000311263200039
项目编号2010CB12300 ; 30670619 ; 81072017 ; 20932001 ; 20852001
资助机构National Basic Research Program of China (973 Program) ; Natural Science Foundation of China
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57085
专题北京大学第一临床医学院_肿瘤化疗科
北京大学药学院_药学院
北京大学第一临床医学院_放射治疗科
作者单位1.Peking Univ, Hosp 1, Dept Radiat Oncol, Beijing 100871, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100871, Peoples R China
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GB/T 7714
Yu, Hongliang,Li, Xiaoying,Sun, Shaoqian,et al. c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,427(3):659-665.
APA Yu, Hongliang,Li, Xiaoying,Sun, Shaoqian,Gao, Xianshu,&Zhou, Demin.(2012).c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,427(3),659-665.
MLA Yu, Hongliang,et al."c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 427.3(2012):659-665.
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