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学科主题: 临床医学
题名:
Distinct roles of VEGF-A and VEGF-C in tumour metastasis of gastric carcinoma
作者: Ding, Shigang; Li, Chenggang; Lin, Sanren; Han, Yajing; Yang, Yu; Zhang, Ying; Li, Lina; Zhou, Liya; Kumar, Shant
关键词: gastric carcinoma ; VEGF-A ; VEGF-C ; lymphangiogenesis ; angiogenesis
刊名: ONCOLOGY REPORTS
发表日期: 2007-02-01
卷: 17, 期:2, 页:369-375
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ENDOTHELIAL GROWTH-FACTOR ; MALIGNANT ASCITES ; LYMPHANGIOGENESIS ; ANGIOGENESIS ; CANCER ; MECHANISMS ; EXPRESSION ; CD105
英文摘要:

The expression of VEGF-A and -C was investigated immunohistochemically in 51 specimens of gastric carcinoma. The expression intensity was evaluated by means of a semiquantitative scoring system and a quantitative analysis. The results showed that VEGF-A and -C were located mainly in the cytoplasm of tumour cells: 68.6% (34/51) and 62.8% (32/51) positive for VEGF-A and VEGF-C. VEGF-C expression was more frequent in tumours of the deceased patients [88.2% (15/17)] compared to that in the survivors [47.0% (16/34)]. Quantitative VEGF-C levels in the deceased patients were 0.304 +/- 0.023, which was significantly elevated compared to that in the survivors (0.131 +/- 0.018) (p < 0.01). The frequency of VEGF-C expression was higher in patients with lymph node metastases (80.0%, 28/35) compared to those with negative nodes (25%, 4/16). Accordingly, its levels were markedly elevated in the former (0.230 +/- 0.017) than in the latter (0.089 +/- 0.011) (p < 0.01). Furthermore, tumour cell invasion into the enlarged lymphatic vessels was also associated with VEGF-C expression. Its expression levels were 0.271 +/- 0.028 in lymph vessel invasion and 0.153 +/- 0.021 in the absence of invasion (p < 0.01). VEGF-A expression, although correlated with survival, distant metastasis, ascites formation, and blood vessel invasion, was not associate with lymph node metastasis, lymphatic vessel invasion. The expression levels of the two factors were inversely correlated with overall survival rates. It can be conclude that VEGF-C expression in tumour tissues is indicative of lymphatic metastasis, whereas VEGF-A expression is more likely to be associated with haematogenous metastasis. Both VEGF-A and -C could serve as a prognostic biomarker in patients with gastric carcinoma.

语种: 英语
WOS记录号: WOS:000243611400016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57087
Appears in Collections:北京大学第三临床医学院_消化科_期刊论文

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作者单位: 1.Univ Manchester, Sch Med, Dept Pathol, Manchester M13 9PT, Lancs, England
2.Univ Manchester, Chrisite Hosp, Manchester M13 9PT, Lancs, England
3.Peking Univ, Third Hosp, Dept Gastroenterol, Beijing 100083, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China

Recommended Citation:
Ding, Shigang,Li, Chenggang,Lin, Sanren,et al. Distinct roles of VEGF-A and VEGF-C in tumour metastasis of gastric carcinoma[J]. ONCOLOGY REPORTS,2007,17(2):369-375.
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