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Distinct roles of VEGF-A and VEGF-C in tumour metastasis of gastric carcinoma
Ding, Shigang; Li, Chenggang; Lin, Sanren; Han, Yajing; Yang, Yu; Zhang, Ying; Li, Lina; Zhou, Liya; Kumar, Shant
关键词Gastric Carcinoma Vegf-a Vegf-c Lymphangiogenesis Angiogenesis
刊名ONCOLOGY REPORTS
2007-02-01
17期:2页:369-375
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; MALIGNANT ASCITES ; LYMPHANGIOGENESIS ; ANGIOGENESIS ; CANCER ; MECHANISMS ; EXPRESSION ; CD105
英文摘要

The expression of VEGF-A and -C was investigated immunohistochemically in 51 specimens of gastric carcinoma. The expression intensity was evaluated by means of a semiquantitative scoring system and a quantitative analysis. The results showed that VEGF-A and -C were located mainly in the cytoplasm of tumour cells: 68.6% (34/51) and 62.8% (32/51) positive for VEGF-A and VEGF-C. VEGF-C expression was more frequent in tumours of the deceased patients [88.2% (15/17)] compared to that in the survivors [47.0% (16/34)]. Quantitative VEGF-C levels in the deceased patients were 0.304 +/- 0.023, which was significantly elevated compared to that in the survivors (0.131 +/- 0.018) (p < 0.01). The frequency of VEGF-C expression was higher in patients with lymph node metastases (80.0%, 28/35) compared to those with negative nodes (25%, 4/16). Accordingly, its levels were markedly elevated in the former (0.230 +/- 0.017) than in the latter (0.089 +/- 0.011) (p < 0.01). Furthermore, tumour cell invasion into the enlarged lymphatic vessels was also associated with VEGF-C expression. Its expression levels were 0.271 +/- 0.028 in lymph vessel invasion and 0.153 +/- 0.021 in the absence of invasion (p < 0.01). VEGF-A expression, although correlated with survival, distant metastasis, ascites formation, and blood vessel invasion, was not associate with lymph node metastasis, lymphatic vessel invasion. The expression levels of the two factors were inversely correlated with overall survival rates. It can be conclude that VEGF-C expression in tumour tissues is indicative of lymphatic metastasis, whereas VEGF-A expression is more likely to be associated with haematogenous metastasis. Both VEGF-A and -C could serve as a prognostic biomarker in patients with gastric carcinoma.

语种英语
WOS记录号WOS:000243611400016
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57087
专题北京大学第三临床医学院_消化科
作者单位1.Univ Manchester, Sch Med, Dept Pathol, Manchester M13 9PT, Lancs, England
2.Univ Manchester, Chrisite Hosp, Manchester M13 9PT, Lancs, England
3.Peking Univ, Third Hosp, Dept Gastroenterol, Beijing 100083, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100083, Peoples R China
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GB/T 7714
Ding, Shigang,Li, Chenggang,Lin, Sanren,et al. Distinct roles of VEGF-A and VEGF-C in tumour metastasis of gastric carcinoma[J]. ONCOLOGY REPORTS,2007,17(2):369-375.
APA Ding, Shigang.,Li, Chenggang.,Lin, Sanren.,Han, Yajing.,Yang, Yu.,...&Kumar, Shant.(2007).Distinct roles of VEGF-A and VEGF-C in tumour metastasis of gastric carcinoma.ONCOLOGY REPORTS,17(2),369-375.
MLA Ding, Shigang,et al."Distinct roles of VEGF-A and VEGF-C in tumour metastasis of gastric carcinoma".ONCOLOGY REPORTS 17.2(2007):369-375.
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