学科主题基础医学
ASEB: a web server for KAT-specific acetylation site prediction
Wang, Likun1,2; Du, Yipeng3; Lu, Ming4; Li, Tingting1
刊名NUCLEIC ACIDS RESEARCH
2012-07-01
DOI10.1093/nar/gks437
40期:W1页:W376-W379
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
资助者The National Basic Research Program ; National High-tech R&amp ; D Program of China ; National Natural Science Foundation of China ; The National Basic Research Program ; National High-tech R&amp ; D Program of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]SUPPORT VECTOR MACHINES ; LYSINE ACETYLATION ; HISTONE ACETYLTRANSFERASES ; NONHISTONE PROTEINS ; DNA-BINDING ; IN-VIVO ; NETWORKS ; DOMAIN
英文摘要

Protein lysine acetylation plays an important role in the normal functioning of cells, including gene expression regulation, protein stability and metabolism regulation. Although large amounts of lysine acetylation sites have been identified via large-scale mass spectrometry or traditional experimental methods, the lysine (K)-acetyl-transferase (KAT) responsible for the acetylation of a given protein or lysine site remains largely unknown due to the experimental limitations of KAT substrate identification. Hence, the in silico prediction of KAT-specific acetylation sites may provide direction for further experiments. In our previous study, we developed the acetylation set enrichment based (ASEB) computer program to predict which KAT-families are responsible for the acetylation of a given protein or lysine site. In this article, we provide KAT-specific acetylation site prediction as a web service. This web server not only provides the online tool and R package for the method in our previous study, but several useful services are also included, such as the integration of protein-protein interaction information to enhance prediction accuracy. This web server can be freely accessed at http://cmbi.bjmu.edu.cn/huac.

语种英语
所属项目编号2011CBA01104 ; 2012AA020401 ; 60905014 ; 31030041
资助者The National Basic Research Program ; National High-tech R&amp ; D Program of China ; National Natural Science Foundation of China ; The National Basic Research Program ; National High-tech R&amp ; D Program of China ; National Natural Science Foundation of China
WOS记录号WOS:000306670900062
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57088
专题北京大学基础医学院_北京大学系统生物医学研究所
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Inst Syst Biomed, Beijing 100191, Peoples R China
2.Jilin Univ, Coll Comp Sci & Technol, Changchun 130012, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Sch Basic Med Sci, Beijing 100191, Peoples R China
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GB/T 7714
Wang, Likun,Du, Yipeng,Lu, Ming,et al. ASEB: a web server for KAT-specific acetylation site prediction[J]. NUCLEIC ACIDS RESEARCH,2012,40(W1):W376-W379.
APA Wang, Likun,Du, Yipeng,Lu, Ming,&Li, Tingting.(2012).ASEB: a web server for KAT-specific acetylation site prediction.NUCLEIC ACIDS RESEARCH,40(W1),W376-W379.
MLA Wang, Likun,et al."ASEB: a web server for KAT-specific acetylation site prediction".NUCLEIC ACIDS RESEARCH 40.W1(2012):W376-W379.
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