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学科主题: 基础医学
题名:
ASEB: a web server for KAT-specific acetylation site prediction
作者: Wang, Likun1,2; Du, Yipeng3; Lu, Ming4; Li, Tingting1
刊名: NUCLEIC ACIDS RESEARCH
发表日期: 2012-07-01
DOI: 10.1093/nar/gks437
卷: 40, 期:W1, 页:W376-W379
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: SUPPORT VECTOR MACHINES ; LYSINE ACETYLATION ; HISTONE ACETYLTRANSFERASES ; NONHISTONE PROTEINS ; DNA-BINDING ; IN-VIVO ; NETWORKS ; DOMAIN
英文摘要:

Protein lysine acetylation plays an important role in the normal functioning of cells, including gene expression regulation, protein stability and metabolism regulation. Although large amounts of lysine acetylation sites have been identified via large-scale mass spectrometry or traditional experimental methods, the lysine (K)-acetyl-transferase (KAT) responsible for the acetylation of a given protein or lysine site remains largely unknown due to the experimental limitations of KAT substrate identification. Hence, the in silico prediction of KAT-specific acetylation sites may provide direction for further experiments. In our previous study, we developed the acetylation set enrichment based (ASEB) computer program to predict which KAT-families are responsible for the acetylation of a given protein or lysine site. In this article, we provide KAT-specific acetylation site prediction as a web service. This web server not only provides the online tool and R package for the method in our previous study, but several useful services are also included, such as the integration of protein-protein interaction information to enhance prediction accuracy. This web server can be freely accessed at http://cmbi.bjmu.edu.cn/huac.

语种: 英语
所属项目编号: 2011CBA01104 ; 2012AA020401 ; 60905014 ; 31030041
项目资助者: The National Basic Research Program ; National High-tech R&amp ; D Program of China ; National Natural Science Foundation of China
WOS记录号: WOS:000306670900062
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57088
Appears in Collections:基础医学院_北京大学系统生物医学研究所_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Inst Syst Biomed, Beijing 100191, Peoples R China
2.Jilin Univ, Coll Comp Sci & Technol, Changchun 130012, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Key Lab Carcinogenesis & Translat Res, Minist Educ,Dept Biochem & Mol Biol, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Biomed Informat, Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Wang, Likun,Du, Yipeng,Lu, Ming,et al. ASEB: a web server for KAT-specific acetylation site prediction[J]. NUCLEIC ACIDS RESEARCH,2012,40(W1):W376-W379.
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