IR@PKUHSC  > 基础医学院  > 心血管所
学科主题基础医学
Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific
Wang, NP; Miao, H; Li, YS; Zhang, P; Haga, JH; Hu, YL; Young, A; Yuan, SL; Nguyen, P; Wu, CC; Chien, S
关键词Apoptosis Endothelium Gene Expression Shear Stress Transcription Factor
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2006-03-24
DOI10.1016/j.bbrc.2006.01.089
341期:4页:1244-1251
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]VASCULAR ENDOTHELIAL-CELLS ; TRANSCRIPTION FACTOR ; TYROSINE KINASES ; NUCLEAR PROTEINS ; SRC FAMILY ; GENE ; ATHEROSCLEROSIS ; IDENTIFICATION ; HEMODYNAMICS ; BIFURCATION
英文摘要

Flow patterns in blood vessels contribute to focal distribution of atherosclerosis; the underlying mechanotransduction pathways remain to be investigated. We demonstrate that different flow patterns elicit distinct responses of Kruppel-like factor-2 (KLF2) in endothelial cells (ECs) in vitro and in vivo. While pulsatile flow with a significant forward direction induced sustained expression of KLF2 in cultured ECs, oscillatory flow with little forward direction caused prolonged suppression after a transient induction. The suppressive effect of oscillatory flow was Src-dependent. Immunohistochemical studies on ECs at arterial branch points revealed that KLF2 protein levels were related to local hemodynamics. Such flow-associated expression patterns were also demonstrated in a rat aortic restenosis model. Inhibition of KLF2 with siRNA sensitized ECs to oxidized LDL-induced apoptosis, indicating a protective role of KLF2. In conclusion, differential regulation of KLF2 may mediate the distinct vascular effects induced by various patterns of shear stress. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000235699900049
引用统计
被引频次:80[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57093
专题基础医学院_心血管所
作者单位1.Univ Calif San Diego, Whitaker Inst Biomed Engn, Dept Bioengn, La Jolla, CA 92093 USA
2.Univ Calif San Diego, Whitaker Inst Biomed Engn, Dept Med, La Jolla, CA 92093 USA
3.Peking Univ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Wang, NP,Miao, H,Li, YS,et al. Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,341(4):1244-1251.
APA Wang, NP.,Miao, H.,Li, YS.,Zhang, P.,Haga, JH.,...&Chien, S.(2006).Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,341(4),1244-1251.
MLA Wang, NP,et al."Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 341.4(2006):1244-1251.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
1-s2.0-S0006291X0600(436KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, NP]的文章
[Miao, H]的文章
[Li, YS]的文章
百度学术
百度学术中相似的文章
[Wang, NP]的文章
[Miao, H]的文章
[Li, YS]的文章
必应学术
必应学术中相似的文章
[Wang, NP]的文章
[Miao, H]的文章
[Li, YS]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 1-s2.0-S0006291X06001136-main.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。