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学科主题: 基础医学
题名:
Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific
作者: Wang, NP; Miao, H; Li, YS; Zhang, P; Haga, JH; Hu, YL; Young, A; Yuan, SL; Nguyen, P; Wu, CC; Chien, S
关键词: apoptosis ; endothelium ; gene expression ; shear stress ; transcription factor
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2006-03-24
DOI: 10.1016/j.bbrc.2006.01.089
卷: 341, 期:4, 页:1244-1251
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: VASCULAR ENDOTHELIAL-CELLS ; TRANSCRIPTION FACTOR ; TYROSINE KINASES ; NUCLEAR PROTEINS ; SRC FAMILY ; GENE ; ATHEROSCLEROSIS ; IDENTIFICATION ; HEMODYNAMICS ; BIFURCATION
英文摘要:

Flow patterns in blood vessels contribute to focal distribution of atherosclerosis; the underlying mechanotransduction pathways remain to be investigated. We demonstrate that different flow patterns elicit distinct responses of Kruppel-like factor-2 (KLF2) in endothelial cells (ECs) in vitro and in vivo. While pulsatile flow with a significant forward direction induced sustained expression of KLF2 in cultured ECs, oscillatory flow with little forward direction caused prolonged suppression after a transient induction. The suppressive effect of oscillatory flow was Src-dependent. Immunohistochemical studies on ECs at arterial branch points revealed that KLF2 protein levels were related to local hemodynamics. Such flow-associated expression patterns were also demonstrated in a rat aortic restenosis model. Inhibition of KLF2 with siRNA sensitized ECs to oxidized LDL-induced apoptosis, indicating a protective role of KLF2. In conclusion, differential regulation of KLF2 may mediate the distinct vascular effects induced by various patterns of shear stress. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000235699900049
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57093
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: 1.Univ Calif San Diego, Whitaker Inst Biomed Engn, Dept Bioengn, La Jolla, CA 92093 USA
2.Univ Calif San Diego, Whitaker Inst Biomed Engn, Dept Med, La Jolla, CA 92093 USA
3.Peking Univ, Inst Cardiovasc Sci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, NP,Miao, H,Li, YS,et al. Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,341(4):1244-1251.
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