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学科主题: 药学
题名:
Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells
作者: Qian, Ping; Yang, Xiu-Wei
关键词: Coptidis Rhizoma-Euodiae Fructus couple ; Indoloquinazoline ; Benzylisoquinoline ; Isoindoline ; Coptichine ; Cytotoxicity
刊名: FITOTERAPIA
发表日期: 2014-03-01
DOI: 10.1016/j.fitote.2013.12.016
卷: 93, 页:74-80
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TRADITIONAL CHINESE MEDICINE ; GROWTH
英文摘要:

A new indoloquinazoline alkaloid, 10-methoxywuchuyuamide 1(1), three new benzylisoquinoline alkaloids, named as coptichic aldehyde (2), coptichine (3) and 13-carboxaldehyde-8-oxocoptisine (4), and a new isoindoline alkaloid, named as coptichinamide (5), together with two known alkaloids, wuchuyuamide I (6) and 8-oxocoptisine (7) were isolated from the Coptidis Rhizoma-Euodiae Fructus couple. Their chemical structures were determined by extensive spectroscopic analyses, including IR. UV, EI-MS, HRESI-MS, 1D and 2D NMR data (H-1 NMR, C-13 NMR, H-1-H-1 COSY, HSQC and HMBC). Cytotoxicities of the isolated alkaloids against NCI-N87 and Caco-2 cell lines were evaluated. Four benzylisoquinoline alkaloids 2-4 and 7 showed inhibitory activities against NCI-N87 cell with IC50 values range from 8.92 to 35.98 mu M. The alkaloid 3 was a new antiproliferation compound against NCI-N87 cells. The results provided valuable information for further investigation of alkaloid 3 as a chemopreventive agent. (C) 2013 Published by Elsevier B.V.

语种: 英语
所属项目编号: 81173508 ; 2011BAI07B08
项目资助者: National Natural Science Foundation of China ; National Key Technology R &amp ; D Program of China
WOS记录号: WOS:000333494500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57095
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Nat Med, Sch Pharmaceut Sci,Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Qian, Ping,Yang, Xiu-Wei. Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells[J]. FITOTERAPIA,2014,93:74-80.
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