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Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells
Qian, Ping; Yang, Xiu-Wei
关键词Coptidis Rhizoma-euodiae Fructus Couple Indoloquinazoline Benzylisoquinoline Isoindoline Coptichine Cytotoxicity
刊名FITOTERAPIA
2014-03-01
DOI10.1016/j.fitote.2013.12.016
93页:74-80
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Key Technology R &amp ; D Program of China ; National Natural Science Foundation of China ; National Key Technology R &amp ; D Program of China
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TRADITIONAL CHINESE MEDICINE ; GROWTH
英文摘要

A new indoloquinazoline alkaloid, 10-methoxywuchuyuamide 1(1), three new benzylisoquinoline alkaloids, named as coptichic aldehyde (2), coptichine (3) and 13-carboxaldehyde-8-oxocoptisine (4), and a new isoindoline alkaloid, named as coptichinamide (5), together with two known alkaloids, wuchuyuamide I (6) and 8-oxocoptisine (7) were isolated from the Coptidis Rhizoma-Euodiae Fructus couple. Their chemical structures were determined by extensive spectroscopic analyses, including IR. UV, EI-MS, HRESI-MS, 1D and 2D NMR data (H-1 NMR, C-13 NMR, H-1-H-1 COSY, HSQC and HMBC). Cytotoxicities of the isolated alkaloids against NCI-N87 and Caco-2 cell lines were evaluated. Four benzylisoquinoline alkaloids 2-4 and 7 showed inhibitory activities against NCI-N87 cell with IC50 values range from 8.92 to 35.98 mu M. The alkaloid 3 was a new antiproliferation compound against NCI-N87 cells. The results provided valuable information for further investigation of alkaloid 3 as a chemopreventive agent. (C) 2013 Published by Elsevier B.V.

语种英语
所属项目编号81173508 ; 2011BAI07B08
资助者National Natural Science Foundation of China ; National Key Technology R &amp ; D Program of China ; National Natural Science Foundation of China ; National Key Technology R &amp ; D Program of China
WOS记录号WOS:000333494500009
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57095
专题北京大学药学院_天然药物学系
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Dept Nat Med, Sch Pharmaceut Sci,Hlth Sci Ctr, Beijing 100191, Peoples R China
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Qian, Ping,Yang, Xiu-Wei. Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells[J]. FITOTERAPIA,2014,93:74-80.
APA Qian, Ping,&Yang, Xiu-Wei.(2014).Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells.FITOTERAPIA,93,74-80.
MLA Qian, Ping,et al."Five new alkaloids from Coptidis Rhizoma-Euodiae Fructus couple and their cytotoxic activities against gastrointestinal cancer cells".FITOTERAPIA 93(2014):74-80.
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