北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤内科  > 期刊论文
学科主题: 临床医学
题名:
Immunotherapy of distant metastatic disease
作者: Schadendorf, D.1; Algarra, S. M.2; Bastholt, L.3; Cinat, G.4; Dreno, B.5; Eggermont, A. M. M.6; Espinosa, E.7; Guo, J.8; Hauschild, A.9; Petrella, T.10; Schachter, J.11; Hersey, P.12
关键词: adoptive immunotherapy ; anti-CTLA-4 ; interferon ; interleukin ; metastatic melanoma ; vaccine
刊名: ANNALS OF ONCOLOGY
发表日期: 2009-08-01
DOI: 10.1093/annonc/mdp253
卷: suppl.6, 页:41-50
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: RANDOMIZED PHASE-III ; COOPERATIVE-ONCOLOGY-GROUP ; STAGE-IV MELANOMA ; TUMOR-INFILTRATING LYMPHOCYTES ; AMERICAN JOINT COMMITTEE ; HIGH-DOSE INTERLEUKIN-2 ; ADOPTIVE CELL TRANSFER ; ALPHA IFN-ALPHA ; CD8(+) T-CELLS ; MALIGNANT-MELANOMA
英文摘要:

Immunotherapy of metastatic melanoma consists of various approaches leading to specific or non-specific immunomodulation. The use of FDA-approved interleukin (IL)-2 alone, in combination with interferon alpha, and/or with various chemotherapeutic agents (biochemotherapy) is associated with significant toxicity and poor efficacy that does not improve overall survival of 96% of patients. Many studies with allogeneic and autologous vaccines have demonstrated no clinical benefit, and some randomised trials even showed a detrimental effect in the vaccine arm. The ongoing effort to develop melanoma vaccines based on dendritic cells and peptides is driven by advances in understanding antigen presentation and processing, and by new techniques of vaccine preparation, stabilisation and delivery. Several agents that have shown promising activity in metastatic melanoma including IL-21 and monoclonal antibodies targeting cytotoxic T lymphocyte-associated antigen 4 (anti-CTLA-4) or CD137 are discussed. Recent advances of intratumour gene transfer technologies and adoptive immunotherapy, which represents a promising although technically challenging direction, are also discussed.

语种: 英语
WOS记录号: WOS:000268912500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57096
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Univ Hosp Essen, Dept Dermatol, D-45122 Essen, Germany
2.Univ Navarra Clin, Dept Oncol, Pamplona, Spain
3.Odense Univ Hosp, Dept Oncol, DK-5000 Odense, Denmark
4.Inst Oncol Angel Roffo, Dept Oncol, Buenos Aires, DF, Argentina
5.Ella Inst Treatment & Res Melanoma, Tel Hashomer, Israel
6.Hop Hotel Dieu, Dermatol Clin, Nantes 01, France
7.Hosp La Paz, Dept Oncol, Madrid, Spain
8.Univ Kiel, Dept Dermatol, D-2300 Kiel, Germany
9.Toronto Sunnybrook Reg Canc Ctr, Toronto, ON, Canada
10.Erasmus Univ, Med Ctr, Dr Daniel Den Hoed Canc Ctr, Dept Surg Oncol, Rotterdam, Netherlands
11.Peking Univ, Sch Oncol, Dept Oncol, Beijing 100871, Peoples R China
12.Calvary Mater Newcastle Hosp, Immunol & Oncol Unit, Newcastle, NSW, Australia

Recommended Citation:
Schadendorf, D.,Algarra, S. M.,Bastholt, L.,et al. Immunotherapy of distant metastatic disease[J]. ANNALS OF ONCOLOGY,2009,suppl.6:41-50.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Schadendorf, D.]'s Articles
[Algarra, S. M.]'s Articles
[Bastholt, L.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Schadendorf, D.]‘s Articles
[Algarra, S. M.]‘s Articles
[Bastholt, L.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace