IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤内科
学科主题临床医学
Immunotherapy of distant metastatic disease
Schadendorf, D.1; Algarra, S. M.2; Bastholt, L.3; Cinat, G.4; Dreno, B.5; Eggermont, A. M. M.6; Espinosa, E.7; Guo, J.8; Hauschild, A.9; Petrella, T.10; Schachter, J.11; Hersey, P.12
关键词Adoptive Immunotherapy Anti-ctla-4 Interferon Interleukin Metastatic Melanoma Vaccine
刊名ANNALS OF ONCOLOGY
2009-08-01
DOI10.1093/annonc/mdp253
suppl.6页:41-50
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]RANDOMIZED PHASE-III ; COOPERATIVE-ONCOLOGY-GROUP ; STAGE-IV MELANOMA ; TUMOR-INFILTRATING LYMPHOCYTES ; AMERICAN JOINT COMMITTEE ; HIGH-DOSE INTERLEUKIN-2 ; ADOPTIVE CELL TRANSFER ; ALPHA IFN-ALPHA ; CD8(+) T-CELLS ; MALIGNANT-MELANOMA
英文摘要

Immunotherapy of metastatic melanoma consists of various approaches leading to specific or non-specific immunomodulation. The use of FDA-approved interleukin (IL)-2 alone, in combination with interferon alpha, and/or with various chemotherapeutic agents (biochemotherapy) is associated with significant toxicity and poor efficacy that does not improve overall survival of 96% of patients. Many studies with allogeneic and autologous vaccines have demonstrated no clinical benefit, and some randomised trials even showed a detrimental effect in the vaccine arm. The ongoing effort to develop melanoma vaccines based on dendritic cells and peptides is driven by advances in understanding antigen presentation and processing, and by new techniques of vaccine preparation, stabilisation and delivery. Several agents that have shown promising activity in metastatic melanoma including IL-21 and monoclonal antibodies targeting cytotoxic T lymphocyte-associated antigen 4 (anti-CTLA-4) or CD137 are discussed. Recent advances of intratumour gene transfer technologies and adoptive immunotherapy, which represents a promising although technically challenging direction, are also discussed.

语种英语
WOS记录号WOS:000268912500008
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57096
专题北京大学临床肿瘤学院_肿瘤内科
作者单位1.Univ Hosp Essen, Dept Dermatol, D-45122 Essen, Germany
2.Univ Navarra Clin, Dept Oncol, Pamplona, Spain
3.Odense Univ Hosp, Dept Oncol, DK-5000 Odense, Denmark
4.Inst Oncol Angel Roffo, Dept Oncol, Buenos Aires, DF, Argentina
5.Ella Inst Treatment & Res Melanoma, Tel Hashomer, Israel
6.Hop Hotel Dieu, Dermatol Clin, Nantes 01, France
7.Hosp La Paz, Dept Oncol, Madrid, Spain
8.Univ Kiel, Dept Dermatol, D-2300 Kiel, Germany
9.Toronto Sunnybrook Reg Canc Ctr, Toronto, ON, Canada
10.Erasmus Univ, Med Ctr, Dr Daniel Den Hoed Canc Ctr, Dept Surg Oncol, Rotterdam, Netherlands
11.Peking Univ, Sch Oncol, Dept Oncol, Beijing 100871, Peoples R China
12.Calvary Mater Newcastle Hosp, Immunol & Oncol Unit, Newcastle, NSW, Australia
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GB/T 7714
Schadendorf, D.,Algarra, S. M.,Bastholt, L.,et al. Immunotherapy of distant metastatic disease[J]. ANNALS OF ONCOLOGY,2009,suppl.6:41-50.
APA Schadendorf, D..,Algarra, S. M..,Bastholt, L..,Cinat, G..,Dreno, B..,...&Hersey, P..(2009).Immunotherapy of distant metastatic disease.ANNALS OF ONCOLOGY,suppl.6,41-50.
MLA Schadendorf, D.,et al."Immunotherapy of distant metastatic disease".ANNALS OF ONCOLOGY suppl.6(2009):41-50.
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