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Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenia patients with tardive dyskinesia
Zhang, Xiang Yang; Tan, Yun Long; Zhou, Dong Feng; Cao, Lian Yuan; Wu, Gui Ying; Haile, Colin N.; Kosten, Theresa A.; Kosten, Thomas R.
刊名JOURNAL OF CLINICAL PSYCHIATRY
2007-05-01
68期:5页:754-760
收录类别SCI ; SSCI
文章类型Article
WOS标题词Social Sciences ; Science & Technology
类目[WOS]Psychology, Clinical ; Psychiatry
研究领域[WOS]Psychology ; Psychiatry
关键词[WOS]VITAMIN-E TREATMENT ; MANGANESE SUPEROXIDE-DISMUTASE ; INDUCED OROFACIAL DYSKINESIA ; FREE-RADICAL PATHOLOGY ; OXIDATIVE STRESS ; POLYMORPHISM ; INVOLVEMENT ; PLASMA
英文摘要

Background: Free radical-mediated pathology has been implicated in the development of tardive dyskinesia (TD). Antioxidant defense system alterations and increased lipid peroxidation have been postulated as a possible mechanism for neuronal damage associated with TD. However, the relationship between antioxidant enzymes, lipid peroxidation products, and the severity of TD symptoms has not been determined within a single patient group.

Method: Plasma levels of malondialdehyde (MDA), a marker of lipid peroxidation, superoxide dismutase, glutathione peroxidase, and catalase were examined in 80 patients with schizophrenia (DSM-IV criteria) and TD (Schooler-Kane criteria) and 45 schizophrenia patients without TD. Results were compared to those of 50 age-, sex-, and smoking status-matched controls. Tardive dyskinesia severity was assessed using the Abnormal Involuntary Movement Scale, and patient psychopathology was assessed using the Positive and Negative Syndrome Scale.

Results: Patients with TD had lower plasma superoxide dismutase, glutathione peroxidase, and catalase levels but higher MDA levels than those without TD. In the patients with TD, MDA levels were positively correlated with Abnormal Involuntary Movement Scale total score and with Positive and Negative Syndrome Scale negative subscore. Superoxide dismutase and catalase activities were inversely correlated with MDA levels.

Conclusions: Our data support the hypothesis that oxidative stress is involved in the pathophysiology of TD. These data also suggest a relationship between oxidative stress and the severity of dyskinesia in TD patients. Increased lipid peroxidation may likely be a result of decreased endogenous antioxidant enzyme activities in TD.

语种英语
WOS记录号WOS:000246740300032
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被引频次:48[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57097
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China
2.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China
3.Baylor Coll Med, VA Med Ctr, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Zhang, Xiang Yang,Tan, Yun Long,Zhou, Dong Feng,et al. Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenia patients with tardive dyskinesia[J]. JOURNAL OF CLINICAL PSYCHIATRY,2007,68(5):754-760.
APA Zhang, Xiang Yang.,Tan, Yun Long.,Zhou, Dong Feng.,Cao, Lian Yuan.,Wu, Gui Ying.,...&Kosten, Thomas R..(2007).Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenia patients with tardive dyskinesia.JOURNAL OF CLINICAL PSYCHIATRY,68(5),754-760.
MLA Zhang, Xiang Yang,et al."Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenia patients with tardive dyskinesia".JOURNAL OF CLINICAL PSYCHIATRY 68.5(2007):754-760.
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