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学科主题: 精神卫生
题名:
Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenia patients with tardive dyskinesia
作者: Zhang, Xiang Yang; Tan, Yun Long; Zhou, Dong Feng; Cao, Lian Yuan; Wu, Gui Ying; Haile, Colin N.; Kosten, Theresa A.; Kosten, Thomas R.
刊名: JOURNAL OF CLINICAL PSYCHIATRY
发表日期: 2007-05-01
卷: 68, 期:5, 页:754-760
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Social Sciences ; Science & Technology
类目[WOS]: Psychology, Clinical ; Psychiatry
研究领域[WOS]: Psychology ; Psychiatry
关键词[WOS]: VITAMIN-E TREATMENT ; MANGANESE SUPEROXIDE-DISMUTASE ; INDUCED OROFACIAL DYSKINESIA ; FREE-RADICAL PATHOLOGY ; OXIDATIVE STRESS ; POLYMORPHISM ; INVOLVEMENT ; PLASMA
英文摘要:

Background: Free radical-mediated pathology has been implicated in the development of tardive dyskinesia (TD). Antioxidant defense system alterations and increased lipid peroxidation have been postulated as a possible mechanism for neuronal damage associated with TD. However, the relationship between antioxidant enzymes, lipid peroxidation products, and the severity of TD symptoms has not been determined within a single patient group.

Method: Plasma levels of malondialdehyde (MDA), a marker of lipid peroxidation, superoxide dismutase, glutathione peroxidase, and catalase were examined in 80 patients with schizophrenia (DSM-IV criteria) and TD (Schooler-Kane criteria) and 45 schizophrenia patients without TD. Results were compared to those of 50 age-, sex-, and smoking status-matched controls. Tardive dyskinesia severity was assessed using the Abnormal Involuntary Movement Scale, and patient psychopathology was assessed using the Positive and Negative Syndrome Scale.

Results: Patients with TD had lower plasma superoxide dismutase, glutathione peroxidase, and catalase levels but higher MDA levels than those without TD. In the patients with TD, MDA levels were positively correlated with Abnormal Involuntary Movement Scale total score and with Positive and Negative Syndrome Scale negative subscore. Superoxide dismutase and catalase activities were inversely correlated with MDA levels.

Conclusions: Our data support the hypothesis that oxidative stress is involved in the pathophysiology of TD. These data also suggest a relationship between oxidative stress and the severity of dyskinesia in TD patients. Increased lipid peroxidation may likely be a result of decreased endogenous antioxidant enzyme activities in TD.

语种: 英语
WOS记录号: WOS:000246740300032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57097
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China
2.Beijing Hui Long Guan Hosp, Ctr Biol Psychiat, Beijing, Peoples R China
3.Baylor Coll Med, VA Med Ctr, Dept Psychiat & Behav Sci, Houston, TX 77030 USA

Recommended Citation:
Zhang, Xiang Yang,Tan, Yun Long,Zhou, Dong Feng,et al. Disrupted antioxidant enzyme activity and elevated lipid peroxidation products in schizophrenia patients with tardive dyskinesia[J]. JOURNAL OF CLINICAL PSYCHIATRY,2007,68(5):754-760.
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