IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model
Zheng, Qin1,2; Fang, Dong1,2; Liu, Min1,2; Cai, Jie1,2; Wan, You3,4; Han, Ji-Sheng1,2,3,4; Xing, Guo-Gang1,2,3,4
关键词Bone cancer pain Dorsal root ganglion Hyperexcitability KCNQ channel M current Retigabine XE-991
刊名PAIN
2013-03-01
DOI10.1016/j.pain.2012.12.005
154期:3页:434-448
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anesthesiology ; Clinical Neurology ; Neurosciences
研究领域[WOS]Anesthesiology ; Neurosciences & Neurology
关键词[WOS]MEMBRANE-POTENTIAL OSCILLATIONS ; NR2B-CONTAINING NMDA RECEPTORS ; M-CURRENT MODULATORS ; SRC TYROSINE KINASE ; NEUROPATHIC PAIN ; K+ CHANNELS ; SENSORY NEURONS ; SYMPATHETIC NEURONS ; MEDIATED INHIBITION ; NERVE INJURY
英文摘要

Bone cancer pain has a strong impact on the quality of life of patients, but is difficult to treat. Better understanding of the pathogenic mechanisms underlying bone cancer pain will likely lead to the development of more effective treatments. In the present study, we investigated whether inhibition of KCNQ/M channels contributed to the hyperexcitability of primary sensory neurons and to the pathogenesis of bone cancer pain. By using a rat model of bone cancer pain based on intratibial injection of MRMT-1 tumour cells, we documented a prominent decrease in expression of KCNQ2 and KCNQ3 proteins and a reduction of M-current density in small-sized dorsal root ganglia (DRG) neurons, which were associated with enhanced excitability of these DRG neurons and the hyperalgesic behaviours in bone cancer rats. Coincidently, we found that inhibition of KCNQ/M channels with XE-991 caused a robust increase in the excitability of small-sized DRG neurons and produced an obvious mechanical allodynia in normal rats. On the contrary, activation of the KCNQ/M channels with retigabine not only inhibited the hyperexcitability of these small DRG neurons, but also alleviated mechanical allodynia and thermal hyperalgesia in bone cancer rats, and all of these effects of retigabine could be blocked by KCNQ/M-channel antagonist XE-991. These results suggest that repression of KCNQ/M channels leads to the hyperexcitability of primary sensory neurons, which in turn causes bone cancer pain. Thus, suppression of KCNQ/M channels in primary DRG neurons plays a crucial role in the development of bone cancer pain. (C) 2012 International Association for the Study of Pain. Published by Elsevier B. V. All rights reserved.

语种英语
WOS记录号WOS:000315299800018
项目编号31171063 ; 81072951 ; 61027001 ; 7112079 ; 201302013 ; 2013CB531905
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; special foundation for public welfare profession scientific research program from Ministry of Health of the Peoples Republic of China ; Ministry of Science and Technology of China
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57104
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Neurosci, Beijing, Peoples R China
4.Minist Publ Hlth, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Zheng, Qin,Fang, Dong,Liu, Min,et al. Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model[J]. PAIN,2013,154(3):434-448.
APA Zheng, Qin.,Fang, Dong.,Liu, Min.,Cai, Jie.,Wan, You.,...&Xing, Guo-Gang.(2013).Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model.PAIN,154(3),434-448.
MLA Zheng, Qin,et al."Suppression of KCNQ/M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model".PAIN 154.3(2013):434-448.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Suppression of KCNQ (2477KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Zheng, Qin]的文章
[Fang, Dong]的文章
[Liu, Min]的文章
百度学术
百度学术中相似的文章
[Zheng, Qin]的文章
[Fang, Dong]的文章
[Liu, Min]的文章
必应学术
必应学术中相似的文章
[Zheng, Qin]的文章
[Fang, Dong]的文章
[Liu, Min]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Suppression of KCNQ M (Kv7) potassium channels in dorsal root ganglion neurons contributes to the development of bone cancer pain in a rat model.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。