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学科主题: 临床医学
题名:
Association of Epstein-Barr virus antibody levels with precancerous gastric lesions in a high-risk cohort
作者: Schetter, Aaron J.2; You, Wei-cheng3; Lennette, Evelyne T.4; Gail, Mitchell T.1; Rabkin, Charles S.1
刊名: CANCER SCIENCE
发表日期: 2008-02-01
DOI: 10.1111/j.1349-7006.2007.00668.x
卷: 99, 期:2, 页:350-354
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HELICOBACTER-PYLORI INFECTION ; CANCER ; CARCINOMA ; ADENOCARCINOMA ; POPULATION ; PATTERNS
英文摘要:

We evaluated associations between Epstein-Barr virus (EBV) antibody levels and precancerous gastric lesions (chronic atrophic gastritis, intestinal metaplasia, and dysplasia) in 183 subjects from Linqu, China. Immunoglobulin G antibody titers to EBV nuclear antigen (EBNA) and viral capsid antigen (VCA) were determined by two-fold serial dilution using immunofluorescence assays. Histological progression and regression were assessed by gastroscopic examination at the time of phlebotomy and at follow up 2 years later. Antibody titers did not differ significantly among histological diagnoses determined at the time of phlebotomy. However, subjects with dysplasia at follow up had significantly higher geometric mean antibody titers for both anti-VCA and anti-EBNA. Subjects with greater than median antibody levels were more likely to progress between examinations, especially in the subgroup with intestinal metaplasia at the time of phlebotomy (odds ratios [95% confidence intervals]: 5.7 [1.6-20] for anti-EBNA >= 1:320; 3.8 [1.0-15] for anti-VCA >= 1:640). Our findings suggest a possible role for EBV reactivation at an early phase of gastric carcinogenesis.

语种: 英语
WOS记录号: WOS:000252966800025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57105
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Nectandra Inst, San Ramon, Costa Rica
2.NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA
3.NCI, Canc Prevent Fellowship Program, NIH, Bethesda, MD 20892 USA
4.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Beijing 100036, Peoples R China

Recommended Citation:
Schetter, Aaron J.,You, Wei-cheng,Lennette, Evelyne T.,et al. Association of Epstein-Barr virus antibody levels with precancerous gastric lesions in a high-risk cohort[J]. CANCER SCIENCE,2008,99(2):350-354.
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