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学科主题: 公共卫生
题名:
Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea
作者: Lei, Lou1; Ye, Linan1; Liu, Hong1; Chen, Changzhong2; Fang, Zhian3; Wang, Lihua1; Hu, Yonghua1; Chen, Dafang1
关键词: cytochrome P450 ; dysmenorrhea ; polymorphism ; genetic ; passive smoke
刊名: EUROPEAN JOURNAL OF EPIDEMIOLOGY
发表日期: 2008-07-01
DOI: 10.1007/s10654-008-9250-6
卷: 23, 期:7, 页:475-481
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health
研究领域[WOS]: Public, Environmental & Occupational Health
关键词[WOS]: CIGARETTE-SMOKING ; TOBACCO-SMOKE ; YOUNG-WOMEN ; RISK ; SEVERITY ; WEIGHT ; CANCER ; PAIN ; DNA
英文摘要:

Purpose This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII. Methods This report includes 1,645 (1,124 no dysmenorrhea, 521 dysmenorrhea) non-smoking and non-drinking newly wedding female workers at Anqing, China between June 1997 and June 2000. Multiple logistic regression models were used to estimate the associations of passive smoking exposure and genetic susceptibility with dysmenorrhea, adjusting for maternal age, BMI, age of menarche, education, vibration exposure, shift work, noise exposure, pregnancy history, perceived stress and physical laboring stress. Results In the passive smoking group, women who have C/C6235 genotype (OR = 1.8, 95% CI = 1.0-3.3) in CYP1A1MspI and Ile/Ile462 genotype (OR = 2.9, 95% CI = 1.1-7.7) in CYP1A1HincII was associated with an increased risk of dysmenorrhea. When stratified by women genotype, the adjusted OR of dysmenorrheal was 1.6 (95% CI = 1.2-2.1) for passive smoking group with Ile/Ile462 genotype, and 1.5 (95% CI = 1.0-2.1) with C/C6235 genotype, compared to non-passive smoking group, respectively. The data further showed that there was a significant combined effect between passive smoking and the CYP1A1 Msp1C/C6235 (OR = 1.5, 95% CI = 1.0-2.1), and HincII Ile/Ile462 (OR = 1.6, 95% CI = 1.2-2.1), respectively. Conclusion CYP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.

语种: 英语
WOS记录号: WOS:000256928000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57114
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China
2.Harvard Univ, Sch Med, Brigham & Womens Hosp, Boston, MA USA
3.Anhui Biomed Inst, Hefei, Anhui, Peoples R China

Recommended Citation:
Lei, Lou,Ye, Linan,Liu, Hong,et al. Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea[J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY,2008,23(7):475-481.
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