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Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea
Lei, Lou1; Ye, Linan1; Liu, Hong1; Chen, Changzhong2; Fang, Zhian3; Wang, Lihua1; Hu, Yonghua1; Chen, Dafang1
关键词Cytochrome P450 Dysmenorrhea Polymorphism Genetic Passive Smoke
刊名EUROPEAN JOURNAL OF EPIDEMIOLOGY
2008-07-01
DOI10.1007/s10654-008-9250-6
23期:7页:475-481
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Public, Environmental & Occupational Health
研究领域[WOS]Public, Environmental & Occupational Health
关键词[WOS]CIGARETTE-SMOKING ; TOBACCO-SMOKE ; YOUNG-WOMEN ; RISK ; SEVERITY ; WEIGHT ; CANCER ; PAIN ; DNA
英文摘要

Purpose This study investigated whether the association between passive smoking exposure and dysmenorrhea is modified by two susceptibility genes, CYP1A1MspI and CYP1A1HincII. Methods This report includes 1,645 (1,124 no dysmenorrhea, 521 dysmenorrhea) non-smoking and non-drinking newly wedding female workers at Anqing, China between June 1997 and June 2000. Multiple logistic regression models were used to estimate the associations of passive smoking exposure and genetic susceptibility with dysmenorrhea, adjusting for maternal age, BMI, age of menarche, education, vibration exposure, shift work, noise exposure, pregnancy history, perceived stress and physical laboring stress. Results In the passive smoking group, women who have C/C6235 genotype (OR = 1.8, 95% CI = 1.0-3.3) in CYP1A1MspI and Ile/Ile462 genotype (OR = 2.9, 95% CI = 1.1-7.7) in CYP1A1HincII was associated with an increased risk of dysmenorrhea. When stratified by women genotype, the adjusted OR of dysmenorrheal was 1.6 (95% CI = 1.2-2.1) for passive smoking group with Ile/Ile462 genotype, and 1.5 (95% CI = 1.0-2.1) with C/C6235 genotype, compared to non-passive smoking group, respectively. The data further showed that there was a significant combined effect between passive smoking and the CYP1A1 Msp1C/C6235 (OR = 1.5, 95% CI = 1.0-2.1), and HincII Ile/Ile462 (OR = 1.6, 95% CI = 1.2-2.1), respectively. Conclusion CYP1A1 MspI and HincII genotypes modified the association between passive smoking and dysmenorrhea.

语种英语
WOS记录号WOS:000256928000005
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57114
专题北京大学公共卫生学院
北京大学基础医学院
北京大学临床肿瘤学院_麻醉科
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100083, Peoples R China
2.Harvard Univ, Sch Med, Brigham & Womens Hosp, Boston, MA USA
3.Anhui Biomed Inst, Hefei, Anhui, Peoples R China
推荐引用方式
GB/T 7714
Lei, Lou,Ye, Linan,Liu, Hong,et al. Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea[J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY,2008,23(7):475-481.
APA Lei, Lou.,Ye, Linan.,Liu, Hong.,Chen, Changzhong.,Fang, Zhian.,...&Chen, Dafang.(2008).Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea.EUROPEAN JOURNAL OF EPIDEMIOLOGY,23(7),475-481.
MLA Lei, Lou,et al."Passive smoking, cytochrome P450 gene polymorphisms and dysmenorrhea".EUROPEAN JOURNAL OF EPIDEMIOLOGY 23.7(2008):475-481.
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