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学科主题: 药学
题名:
Gadolinium-promoted precipitation of calcium phosphate is associated with profibrotic activation of RAW 264.7 macrophages
作者: Gou, Bao-Di; Bian, Sha; Zhang, Tian-Lan; Wang, Kui
关键词: Gadolinium ; Calcium phosphate ; Nephrogenic systemic fibrosis ; Macrophage ; Cytokine
刊名: TOXICOLOGY IN VITRO
发表日期: 2010-09-01
DOI: 10.1016/j.tiv.2010.05.004
卷: 24, 期:6, 页:1743-1749
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Toxicology
研究领域[WOS]: Toxicology
关键词[WOS]: NEPHROGENIC SYSTEMIC FIBROSIS ; RARE-EARTH METALS ; CRYSTAL-GROWTH ; TISSUE ; NSF ; CALCIFICATION ; DEPOSITION ; DERMOPATHY ; CRYSTALLIZATION ; EXPRESSION
英文摘要:

Gadolinium-based contrast agents are now being linked to nephrogenic systemic fibrosis (NSF). The exact mechanism by which gadolinium species act in the pathogenesis of NSF is not fully understood. In this study, we evaluated the effect of gadolinium chloride (GdCl(3)) on the precipitation of calcium phosphate, and examined the role of the gadolinium-containing precipitates in the profibrotic activation of macrophages. In a free-drift system, the induction time was markedly reduced with increasing concentration of GdCl(3), accompanied by alterations of morphology and composition of the precipitates. In complete cell culture medium, the addition of GdCl(3) resulted in formation of particles around 200-300 nm. In an in vitro cellular model with RAW 264.7 macrophages, GdCl(3) increased the production of TGF-beta 1 and IL-6 via the activation of PKC and ERK signaling pathway. Our findings demonstrate that GdCl(3) promotes calcium phosphate precipitation and induces profibrotic activation of macrophages. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 20571006 ; 20637010
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000282114400035
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57116
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100191, Peoples R China

Recommended Citation:
Gou, Bao-Di,Bian, Sha,Zhang, Tian-Lan,et al. Gadolinium-promoted precipitation of calcium phosphate is associated with profibrotic activation of RAW 264.7 macrophages[J]. TOXICOLOGY IN VITRO,2010,24(6):1743-1749.
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