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学科主题: 基础医学
题名:
Immunoglobulin G Expression and its Potential Role in Primary and Metastatic Breast Cancers
作者: Ma, C.1,2; Wang, Y.1,3; Zhang, G.4; Chen, Z.1; Qiu, Y.1; Li, J.1; Luo, J.1; Huang, B.1; Jiang, C.1; Huang, G.1; Wan, X.1; Korteweg, C.1; Gu, J.1,5
关键词: Breast cancer ; complement ; immune escape ; immunoglobulin G ; metastasis
刊名: CURRENT MOLECULAR MEDICINE
发表日期: 2013-03-01
卷: 13, 期:3, 页:429-437
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: CELL-LINES ; GENE TRANSCRIPTS ; CA215 ; ACTIVATION ; COMPLEXES ; BIOMARKER ; SURVIVAL ; RECEPTOR ; GROWTH ; LUNGS
英文摘要:

Recently immunoglobulin G (IgG) was found to be produced by neoplasms and promote tumor growth in cancer cell lines and animal models. To investigate the pathophysiological significance of cancer-produced IgG in breast cancer, we examined the expressions of IgG in 68 breast cancers including 40 primary cancers without metastasis and 28 cancers with axillary lymph node metastases. IgG gene expression was detected in all these samples. We found that IgG-expressing cancer cells were predominantly located in the periphery of the primary cancer nest and that these cells showed more cellular atypia and nuclear pleomorphism. We also found that the abundance of IgG-expressing cancer cells was higher and the cells were more evenly distributed in the metastatic cancer cells than that in the primary lesion. These findings suggest that IgG-expressing breast cancer cells have a more aggressive biological behavior than the IgG negative cancer cells and it could be an indicator for progression and metastasis of the disease. Co-localization of IgG and C1q complement was detected in both primary and metastatic lesions implying that immune complexes might be formed in situ. We speculate that such immune complexes might facilitate immune escape of cancer cells. Our findings suggest that locally produced IgG plays important roles in breast cancer, and may serve as a potential therapeutic target.

语种: 英语
所属项目编号: 81030033 ; 30971150 ; 81001199 ; 30950110335 ; 8451503102001823 ; 186
项目资助者: National Nature Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Guangdong Provincial Key Laboratory ; Science and Technology Foundation of Shantou ; Breast Center in Cancer Hospital of Shantou University Medical College
WOS记录号: WOS:000317116100012
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57117
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Shantou Univ, Coll Med, Guangdong Prov Key Lab Infect Dis & Mol Immunopat, Dept Pathol & Pathophysiol, Shantou 515041, Guangdong, Peoples R China
2.Shantou Univ, Coll Med, Canc Hosp, Dept Radiat Oncol, Shantou 515041, Guangdong, Peoples R China
3.NIMH, Mol Pathophysiol Lab, NIH, Bethesda, MD 20892 USA
4.Shantou Univ, Coll Med, Breast Ctr, Canc Hosp, Shantou 515041, Guangdong, Peoples R China
5.Beijing Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Ma, C.,Wang, Y.,Zhang, G.,et al. Immunoglobulin G Expression and its Potential Role in Primary and Metastatic Breast Cancers[J]. CURRENT MOLECULAR MEDICINE,2013,13(3):429-437.
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