IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Immunoglobulin G Expression and its Potential Role in Primary and Metastatic Breast Cancers
Ma, C.1,2; Wang, Y.1,3; Zhang, G.4; Chen, Z.1; Qiu, Y.1; Li, J.1; Luo, J.1; Huang, B.1; Jiang, C.1; Huang, G.1; Wan, X.1; Korteweg, C.1; Gu, J.1,5
关键词Breast cancer complement immune escape immunoglobulin G metastasis
刊名CURRENT MOLECULAR MEDICINE
2013-03-01
13期:3页:429-437
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]CELL-LINES ; GENE TRANSCRIPTS ; CA215 ; ACTIVATION ; COMPLEXES ; BIOMARKER ; SURVIVAL ; RECEPTOR ; GROWTH ; LUNGS
英文摘要

Recently immunoglobulin G (IgG) was found to be produced by neoplasms and promote tumor growth in cancer cell lines and animal models. To investigate the pathophysiological significance of cancer-produced IgG in breast cancer, we examined the expressions of IgG in 68 breast cancers including 40 primary cancers without metastasis and 28 cancers with axillary lymph node metastases. IgG gene expression was detected in all these samples. We found that IgG-expressing cancer cells were predominantly located in the periphery of the primary cancer nest and that these cells showed more cellular atypia and nuclear pleomorphism. We also found that the abundance of IgG-expressing cancer cells was higher and the cells were more evenly distributed in the metastatic cancer cells than that in the primary lesion. These findings suggest that IgG-expressing breast cancer cells have a more aggressive biological behavior than the IgG negative cancer cells and it could be an indicator for progression and metastasis of the disease. Co-localization of IgG and C1q complement was detected in both primary and metastatic lesions implying that immune complexes might be formed in situ. We speculate that such immune complexes might facilitate immune escape of cancer cells. Our findings suggest that locally produced IgG plays important roles in breast cancer, and may serve as a potential therapeutic target.

语种英语
WOS记录号WOS:000317116100012
项目编号81030033 ; 30971150 ; 81001199 ; 30950110335 ; 8451503102001823 ; 186
资助机构National Nature Science Foundation of China ; Natural Science Foundation of Guangdong Province ; Guangdong Provincial Key Laboratory ; Science and Technology Foundation of Shantou ; Breast Center in Cancer Hospital of Shantou University Medical College
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57117
专题北京大学基础医学院_病理学系
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Shantou Univ, Coll Med, Guangdong Prov Key Lab Infect Dis & Mol Immunopat, Dept Pathol & Pathophysiol, Shantou 515041, Guangdong, Peoples R China
2.Shantou Univ, Coll Med, Canc Hosp, Dept Radiat Oncol, Shantou 515041, Guangdong, Peoples R China
3.NIMH, Mol Pathophysiol Lab, NIH, Bethesda, MD 20892 USA
4.Shantou Univ, Coll Med, Breast Ctr, Canc Hosp, Shantou 515041, Guangdong, Peoples R China
5.Beijing Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100871, Peoples R China
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GB/T 7714
Ma, C.,Wang, Y.,Zhang, G.,et al. Immunoglobulin G Expression and its Potential Role in Primary and Metastatic Breast Cancers[J]. CURRENT MOLECULAR MEDICINE,2013,13(3):429-437.
APA Ma, C..,Wang, Y..,Zhang, G..,Chen, Z..,Qiu, Y..,...&Gu, J..(2013).Immunoglobulin G Expression and its Potential Role in Primary and Metastatic Breast Cancers.CURRENT MOLECULAR MEDICINE,13(3),429-437.
MLA Ma, C.,et al."Immunoglobulin G Expression and its Potential Role in Primary and Metastatic Breast Cancers".CURRENT MOLECULAR MEDICINE 13.3(2013):429-437.
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