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学科主题: 口腔医学
题名:
Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma
作者: Zhang, WM; Lo Muzio, L; Rubini, C; Yan, G
关键词: WNT-1 ; catenin ; cadherin ; Ki-67 ; carcinogenesis ; oral ; squamous cell carcinoma ; head and neck
刊名: ONCOLOGY REPORTS
发表日期: 2005-06-01
卷: 13, 期:6, 页:1095-1099
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: E-CADHERIN ; HEPATOCELLULAR CARCINOMAS ; PROLIFERATIVE ACTIVITY ; NUCLEAR ACCUMULATION ; SIGNAL-TRANSDUCTION ; PROGNOSTIC FACTOR ; LOCALIZATION ; PROGRESSION ; ACTIVATION ; ADHESION
英文摘要:

WNT-1 has been demonstrated to play an important role in the carcinogenesis of some cancers, but its significance in oral squamous cell carcinoma (OSCC) has not yet been elucidated. We investigated the WNT-1 expression in OSCC, its role on the expression of B-catenin and its relation to Ki-67 and tumor differentiation. Surgical specimens from 82 OSCC patients were examined for WNT-1, B-catenin, E-cadherin, gamma-catenin and Ki-67 expression by irnmunohistochemical staining. The results were compared with the clinicopathological data and the relationships were correlated. WNT-1 expression was low in 39 cases, moderate in 5 cases, and high in 38 cases. WNT-1 showed a significant association with the expression of 13-catenin, E-cadherin, gamma-catenin and Ki-67. It was significantly correlated with tumor differentiation. The results of this study showed that WNT-1 expression is correlated with B-catenin, Ki-67 and tumor differentiation, which suggested that WNT-1 might play an important role in the disturbed differentiation and uncontrolled proliferation during OSCC carcinogenesis.

语种: 英语
WOS记录号: WOS:000229057300014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57123
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Univ Foggia, Dept Surg Sci, Foggia, Italy
2.Univ Ancona, Inst Pathol, Ancona, Italy
3.Peking Univ, Coll Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China

Recommended Citation:
Zhang, WM,Lo Muzio, L,Rubini, C,et al. Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma[J]. ONCOLOGY REPORTS,2005,13(6):1095-1099.
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