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学科主题口腔医学
Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma
Zhang, WM; Lo Muzio, L; Rubini, C; Yan, G
关键词Wnt-1 Catenin Cadherin Ki-67 Carcinogenesis Oral Squamous Cell Carcinoma Head And Neck
刊名ONCOLOGY REPORTS
2005-06-01
13期:6页:1095-1099
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]E-CADHERIN ; HEPATOCELLULAR CARCINOMAS ; PROLIFERATIVE ACTIVITY ; NUCLEAR ACCUMULATION ; SIGNAL-TRANSDUCTION ; PROGNOSTIC FACTOR ; LOCALIZATION ; PROGRESSION ; ACTIVATION ; ADHESION
英文摘要

WNT-1 has been demonstrated to play an important role in the carcinogenesis of some cancers, but its significance in oral squamous cell carcinoma (OSCC) has not yet been elucidated. We investigated the WNT-1 expression in OSCC, its role on the expression of B-catenin and its relation to Ki-67 and tumor differentiation. Surgical specimens from 82 OSCC patients were examined for WNT-1, B-catenin, E-cadherin, gamma-catenin and Ki-67 expression by irnmunohistochemical staining. The results were compared with the clinicopathological data and the relationships were correlated. WNT-1 expression was low in 39 cases, moderate in 5 cases, and high in 38 cases. WNT-1 showed a significant association with the expression of 13-catenin, E-cadherin, gamma-catenin and Ki-67. It was significantly correlated with tumor differentiation. The results of this study showed that WNT-1 expression is correlated with B-catenin, Ki-67 and tumor differentiation, which suggested that WNT-1 might play an important role in the disturbed differentiation and uncontrolled proliferation during OSCC carcinogenesis.

语种英语
WOS记录号WOS:000229057300014
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57123
专题北京大学口腔医学院_口腔病理科
作者单位1.Univ Foggia, Dept Surg Sci, Foggia, Italy
2.Univ Ancona, Inst Pathol, Ancona, Italy
3.Peking Univ, Coll Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
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GB/T 7714
Zhang, WM,Lo Muzio, L,Rubini, C,et al. Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma[J]. ONCOLOGY REPORTS,2005,13(6):1095-1099.
APA Zhang, WM,Lo Muzio, L,Rubini, C,&Yan, G.(2005).Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma.ONCOLOGY REPORTS,13(6),1095-1099.
MLA Zhang, WM,et al."Effect of WNT-1 on beta-catenin expression and its relation to Ki-67 and tumor differentiation in oral squamous cell carcinoma".ONCOLOGY REPORTS 13.6(2005):1095-1099.
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