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学科主题: 临床医学
题名:
oxHDL decreases the expression of CD36 on human macrophages through PPAR gamma and p38 MAP kinase dependent mechanisms
作者: Ren, Jingyi; Jin, Wenying; Chen, Hong
关键词: oxHDL ; CD36 ; PPAR gamma ; MAP kinase ; Macrophages ; Atherosclerosis
刊名: MOLECULAR AND CELLULAR BIOCHEMISTRY
发表日期: 2010-09-01
DOI: 10.1007/s11010-010-0481-y
卷: 342, 期:1-2, 页:171-181
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: HIGH-DENSITY-LIPOPROTEIN ; ACTIVATED RECEPTOR-GAMMA ; B SCAVENGER RECEPTOR ; ENDOTHELIAL-CELLS ; GENE-EXPRESSION ; OXIDIZED LDL ; IN-VITRO ; ATHEROSCLEROSIS ; HDL ; MICE
英文摘要:

CD36, belongs to class B scavenger receptor family, is a macrophage receptor for oxidized low-density lipoprotein (oxLDL) and has been proven to play a critical role in atherosclerotic foam cell formation. In addition, CD36 expression is regulated by many factors including oxLDL and HDL. A recent study suggests that CD36 can also bind with oxidized high-density lipoprotein (oxHDL). However, the direct role of oxHDL in atherosclerosis is still not clear and it is not known whether oxHDL has any influence on the expression of CD36 in macrophages. Here, we performed experiments to investigate the effect of oxHDL on the expression of CD36 on human peripheral blood monocytes-macrophages and the possible mechanisms. Our results suggest that the uptake of oxHDL by CD36 on macrophages accelerates foam cell formation. In addition, oxHDL can down-regulate both the mRNA and surface protein expression of CD36 on human peripheral macrophages in vitro. oxHDL increased the mRNA expression and protein phosphorylation of peroxisome proliferators-activated receptor-gamma (PPAR gamma). Using different mitogen-activated protein kinase (MAPK) inhibitors, we demonstrated that oxHDL regulated CD36 and PPAR gamma expression in a p38-MAP kinase dependent mechanism.

语种: 英语
所属项目编号: 30570712
项目资助者: National Natural Sciences Fund Committee in China
WOS记录号: WOS:000281054900020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/57126
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China

Recommended Citation:
Ren, Jingyi,Jin, Wenying,Chen, Hong. oxHDL decreases the expression of CD36 on human macrophages through PPAR gamma and p38 MAP kinase dependent mechanisms[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2010,342(1-2):171-181.
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