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学科主题临床医学
oxHDL decreases the expression of CD36 on human macrophages through PPAR gamma and p38 MAP kinase dependent mechanisms
Ren, Jingyi; Jin, Wenying; Chen, Hong
关键词Oxhdl Cd36 Ppar Gamma Map Kinase Macrophages Atherosclerosis
刊名MOLECULAR AND CELLULAR BIOCHEMISTRY
2010-09-01
DOI10.1007/s11010-010-0481-y
342期:1-2页:171-181
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
资助者National Natural Sciences Fund Committee in China ; National Natural Sciences Fund Committee in China
研究领域[WOS]Cell Biology
关键词[WOS]HIGH-DENSITY-LIPOPROTEIN ; ACTIVATED RECEPTOR-GAMMA ; B SCAVENGER RECEPTOR ; ENDOTHELIAL-CELLS ; GENE-EXPRESSION ; OXIDIZED LDL ; IN-VITRO ; ATHEROSCLEROSIS ; HDL ; MICE
英文摘要

CD36, belongs to class B scavenger receptor family, is a macrophage receptor for oxidized low-density lipoprotein (oxLDL) and has been proven to play a critical role in atherosclerotic foam cell formation. In addition, CD36 expression is regulated by many factors including oxLDL and HDL. A recent study suggests that CD36 can also bind with oxidized high-density lipoprotein (oxHDL). However, the direct role of oxHDL in atherosclerosis is still not clear and it is not known whether oxHDL has any influence on the expression of CD36 in macrophages. Here, we performed experiments to investigate the effect of oxHDL on the expression of CD36 on human peripheral blood monocytes-macrophages and the possible mechanisms. Our results suggest that the uptake of oxHDL by CD36 on macrophages accelerates foam cell formation. In addition, oxHDL can down-regulate both the mRNA and surface protein expression of CD36 on human peripheral macrophages in vitro. oxHDL increased the mRNA expression and protein phosphorylation of peroxisome proliferators-activated receptor-gamma (PPAR gamma). Using different mitogen-activated protein kinase (MAPK) inhibitors, we demonstrated that oxHDL regulated CD36 and PPAR gamma expression in a p38-MAP kinase dependent mechanism.

语种英语
所属项目编号30570712
资助者National Natural Sciences Fund Committee in China ; National Natural Sciences Fund Committee in China
WOS记录号WOS:000281054900020
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/57126
Collection北京大学第二临床医学院_心血管内科
作者单位Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Ren, Jingyi,Jin, Wenying,Chen, Hong. oxHDL decreases the expression of CD36 on human macrophages through PPAR gamma and p38 MAP kinase dependent mechanisms[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2010,342(1-2):171-181.
APA Ren, Jingyi,Jin, Wenying,&Chen, Hong.(2010).oxHDL decreases the expression of CD36 on human macrophages through PPAR gamma and p38 MAP kinase dependent mechanisms.MOLECULAR AND CELLULAR BIOCHEMISTRY,342(1-2),171-181.
MLA Ren, Jingyi,et al."oxHDL decreases the expression of CD36 on human macrophages through PPAR gamma and p38 MAP kinase dependent mechanisms".MOLECULAR AND CELLULAR BIOCHEMISTRY 342.1-2(2010):171-181.
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