学科主题 | 临床医学 |
oxHDL decreases the expression of CD36 on human macrophages through PPAR gamma and p38 MAP kinase dependent mechanisms | |
Ren, Jingyi; Jin, Wenying; Chen, Hong | |
关键词 | Oxhdl Cd36 Ppar Gamma Map Kinase Macrophages Atherosclerosis |
刊名 | MOLECULAR AND CELLULAR BIOCHEMISTRY
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2010-09-01 | |
DOI | 10.1007/s11010-010-0481-y |
卷 | 342期:1-2页:171-181 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Cell Biology |
资助者 | National Natural Sciences Fund Committee in China ; National Natural Sciences Fund Committee in China |
研究领域[WOS] | Cell Biology |
关键词[WOS] | HIGH-DENSITY-LIPOPROTEIN ; ACTIVATED RECEPTOR-GAMMA ; B SCAVENGER RECEPTOR ; ENDOTHELIAL-CELLS ; GENE-EXPRESSION ; OXIDIZED LDL ; IN-VITRO ; ATHEROSCLEROSIS ; HDL ; MICE |
英文摘要 | CD36, belongs to class B scavenger receptor family, is a macrophage receptor for oxidized low-density lipoprotein (oxLDL) and has been proven to play a critical role in atherosclerotic foam cell formation. In addition, CD36 expression is regulated by many factors including oxLDL and HDL. A recent study suggests that CD36 can also bind with oxidized high-density lipoprotein (oxHDL). However, the direct role of oxHDL in atherosclerosis is still not clear and it is not known whether oxHDL has any influence on the expression of CD36 in macrophages. Here, we performed experiments to investigate the effect of oxHDL on the expression of CD36 on human peripheral blood monocytes-macrophages and the possible mechanisms. Our results suggest that the uptake of oxHDL by CD36 on macrophages accelerates foam cell formation. In addition, oxHDL can down-regulate both the mRNA and surface protein expression of CD36 on human peripheral macrophages in vitro. oxHDL increased the mRNA expression and protein phosphorylation of peroxisome proliferators-activated receptor-gamma (PPAR gamma). Using different mitogen-activated protein kinase (MAPK) inhibitors, we demonstrated that oxHDL regulated CD36 and PPAR gamma expression in a p38-MAP kinase dependent mechanism. |
语种 | 英语 |
所属项目编号 | 30570712 |
资助者 | National Natural Sciences Fund Committee in China ; National Natural Sciences Fund Committee in China |
WOS记录号 | WOS:000281054900020 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/57126 |
Collection | 北京大学第二临床医学院_心血管内科 |
作者单位 | Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100871, Peoples R China |
Recommended Citation GB/T 7714 | Ren, Jingyi,Jin, Wenying,Chen, Hong. oxHDL decreases the expression of CD36 on human macrophages through PPAR gamma and p38 MAP kinase dependent mechanisms[J]. MOLECULAR AND CELLULAR BIOCHEMISTRY,2010,342(1-2):171-181. |
APA | Ren, Jingyi,Jin, Wenying,&Chen, Hong.(2010).oxHDL decreases the expression of CD36 on human macrophages through PPAR gamma and p38 MAP kinase dependent mechanisms.MOLECULAR AND CELLULAR BIOCHEMISTRY,342(1-2),171-181. |
MLA | Ren, Jingyi,et al."oxHDL decreases the expression of CD36 on human macrophages through PPAR gamma and p38 MAP kinase dependent mechanisms".MOLECULAR AND CELLULAR BIOCHEMISTRY 342.1-2(2010):171-181. |
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